The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.
Click Chemistry: 1,2,3‐Triazoles as Pharmacophores
Abstract
The copper(I)‐catalyzed 1,2,3‐triazole‐forming reaction between azides and terminal alkynes has become the gold standard of ‘click chemistry’ due to its reliability, specificity, and biocompatibility. Applications of click chemistry are increasingly found in all aspects of drug discovery; they range from lead finding through combinatorial chemistry and target‐templated in vitro chemistry, to proteomics and DNA research by using bioconjugation reactions. The triazole products are more than just passive linkers; they readily associate with biological targets, through hydrogen‐bonding and dipole interactions. The present review will focus mainly on the recent literature for applications of this reaction in the field of medicinal chemistry, in particular on use of the 1,2,3‐triazole moiety as pharmacophore.
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Cites
Tornøe, C. W., Christensen, C., & Meldal, M. (2002) · The Journal of Organic Chemistry · doi:10.1021/jo011148j · Cited by 8,696
Cu-Catalyzed Azide−Alkyne Cycloaddition
Meldal, M., & Tornøe, C. W. (2008) · Chemical Reviews · doi:10.1021/cr0783479 · Cited by 4,628
The growing impact of click chemistry on drug discovery
Kolb, H. C., & Sharpless, K. B. (2003) · Drug Discovery Today · doi:10.1016/s1359-6446(03)02933-7 · Cited by 3,148
1,3‐Dipolar Cycloadditions. Past and Future
Huisgen, R. (1963) · Angewandte Chemie International Edition in English · doi:10.1002/anie.196305651 · Cited by 2,929
Cell Surface Engineering by a Modified Staudinger Reaction
Saxon, E., & Bertozzi, C. R. (2000) · Science · doi:10.1126/science.287.5460.2007 · Cited by 2,460
The growing applications of click chemistry
Moses, J. E., & Moorhouse, A. D. (2007) · Chem. Soc. Rev. · doi:10.1039/b613014n · Cited by 2,367
Asymmetric 1,3-Dipolar Cycloaddition Reactions
Gothelf, K. V., & Jørgensen, K. A. (1998) · Chemical Reviews · doi:10.1021/cr970324e · Cited by 1,912
Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition
Wang, Q., Chan, T. R., Hilgraf, R., Fokin, V. V., Sharpless, K. B., & Finn, M. G. (2003) · Journal of the American Chemical Society · doi:10.1021/ja021381e · Cited by 1,641
Click-Chemie: diverse chemische Funktionalität mit einer Handvoll guter Reaktionen
Kolb, H. C., Finn, M. G., & Sharpless, K. B. (2001) · Angewandte Chemie · doi:10.1002/1521-3757(20010601)113:11<2056::aid-ange2056>3.0.co;2-w · Cited by 1,624
‘Click’ Chemistry in Polymer and Materials Science
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Cited by
Medicinal attributes of 1,2,3-triazoles: Current developments
Dheer, D., Singh, V., & Shankar, R. (2017) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2017.01.010 · Cited by 873
Cu(I)-Catalyzed Click Chemistry in Glycoscience and Their Diverse Applications
Agrahari, A. K., Bose, P., Jaiswal, M. K., Rajkhowa, S., Singh, A. S., Hotha, S., Mishra, N., & Tiwari, V. K. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00920 · Cited by 445
Metadata
- Authors
- Agalave, S. G., Maujan, S. R., & Pore, V. S.
- Venue
- Chemistry – An Asian Journal
- Publisher
- Wiley
- Published
- 2011-08-29
- Volume
- 6
- Issue
- 10
- Pages
- 2696-2718
- ISSN
- 1861-471X (ISSN-L)
- 1861-4728
- OpenAlex
- W1977851521
- Cited by
- 1,305
- References
- 134
- FWCI
- 29.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Agalave, S. G., Maujan, S. R., & Pore, V. S. (2011). Click Chemistry: 1,2,3‐Triazoles as Pharmacophores. Chemistry – An Asian Journal. https://doi.org/10.1002/asia.201100432
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
