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Cited by 157Autism Spectrum Disorder ResearchMicroRNA in disease regulationGenetics and Neurodevelopmental Disorders

Feasibility and relevance of examining lymphoblastoid cell lines to study role of microRNAs in autism

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Talebizadeh, Zohreh, Butler, Merlin G., Theodoro, Mariana F.·2008·Autism Research
DOI 10.1002/aur.33PMC PMC2768334
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Abstract

To assess the feasibility and relevance of using lymphoblastoid cell lines to study the role of noncoding RNAs in the etiology of autism, we evaluated global expression profiling of 470 mature human microRNAs from six subjects with autism compared with six matched controls. Differential expression (either higher or lower) for 9 of the 470 microRNAs was observed in our autism samples compared with controls. Potential target genes for these microRNAs were identified using computer tools, which included several autism susceptibility genes. Our preliminary results indicate microRNAs should be considered and evaluated in the etiology of autism. In addition, analysis of this class of noncoding RNAs in lymphoblastoid cells has the potential to reveal at least a subset of brain‐related microRNAs implicated in autism. Subsequently, this model system should allow for detection of complex subtle changes in susceptibility genes/pathways contributing to autism.

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Authors
Talebizadeh, Z., Butler, M. G., & Theodoro, M. F.
Affiliations
Children's Mercy Hospital (US)
Corresponding author
Talebizadeh, Zohreh
ORCID
Venue
Autism Research
Publisher
Wiley
Published
2008-08
Volume
1
Issue
4
Pages
240-250
ISSN
  • 1939-3792 (ISSN-L)
  • 1939-3806
DOI
10.1002/aur.33
PMC
PMC2768334
OpenAlex
W2156670174
Cited by
157
References
59
Citations by year
2026: 1 · 2025: 7 · 2024: 8 · 2023: 10 · 2022: 6 · 2021: 7 · 2020: 11 · 2019: 11 · 2018: 4 · 2017: 8 · 2016: 14 · 2015: 11 · 2014: 12 · 2013: 12 · 2012: 14
FWCI
0.51
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 45 d)
Locations
  • Autism Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (U24MH081810)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
autism spectrum disorder, microRNA, lymphoblastoid cell lines, non-coding RNA, miRNA expression profiling, autism susceptibility genes, miRNA target genes, autism etiology
MeSH terms
Autistic Disorder, Feasibility Studies, Humans, Leukemia, Lymphoid, Genetic Linkage, RNA, Messenger, Polymerase Chain Reaction, Gene Expression Profiling, MicroRNAs, Cell Line, Tumor

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