Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology

VanWert, Adam L., Gionfriddo, Michael R., Sweet, Douglas H.·2010·Biopharmaceutics & Drug Disposition

Cited by (256)

Items 101–200 of 256

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    Merel van Nuland, Hilde Rosing, Alwin D. R. Huitema, Jos H. Beijnen · 2019 · Clinical Pharmacokinetics
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    Johanna Huttunen, S. K. Adla, M. Markowicz-Piasecka, K. Huttunen · 2022 · Pharmaceutics
  3. Structure–activity relationships of bumetanide derivatives: correlation between diuretic activity in dogs and inhibition of the human NKCC 2 A transporter
    Kasper Lykke, Kathrin Töllner, Kerstin Römermann, Peter W. Feit, Thomas Erker, Nanna MacAulay, Wolfgang Löscher · 2015 · British Journal of Pharmacology
  4. PharmGKB summary
    Yogita Ghodke‐Puranik, Peter L. Anderson, Katrin Sangkuhl, Jatinder Kaur Lamba, Russ Biagio Altman, Teri E. Klein · 2012 · Pharmacogenetics and Genomics
  5. Interaction of Natural Dietary and Herbal Anionic Compounds and Flavonoids with Human Organic Anion Transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11)
    Li Wang, Douglas H. Sweet · 2013 · Evidence-based Complementary and Alternative Medicine
  6. Effects of nonsteroidal anti-inflammatory drugs on the renal excretion of indoxyl sulfate, a nephro-cardiovascular toxin, in rats
    Chung‐Ping Yu, Douglas H. Sweet, Yu‐Hsuan Peng, Yow‐Wen Hsieh, Pei-Dawn Lee Chao, Yu‐Chi Hou, Shiuan-Pey Lin · 2017 · European Journal of Pharmaceutical Sciences
  7. Organic Anion Transporter 6 (Slc22a20) Specificity and Sertoli Cell-Specific Expression Provide New Insight on Potential Endogenous Roles
    Gloriane Schnabolk, Bhawna Gupta, Aditi Mulgaonkar, Mrugaya P. Kulkarni, Douglas H. Sweet · 2010 · Journal of Pharmacology and Experimental Therapeutics
  8. Altered Renal Expression of Relevant Clinical Drug Transporters in Different Models of Acute Uremia in Rats. Role of Urea Levels
    Anabel Brandoni, Adriana M. Torres · 2015 · Cellular Physiology and Biochemistry
  9. Carrier-Mediated Transport of Nicotine Across the Inner Blood–Retinal Barrier: Involvement of a Novel Organic Cation Transporter Driven by an Outward H+ Gradient
    Yuma Tega, Yoshiyuki Kubo, Chihiro Yuzurihara, Shin‐ichi Akanuma, Ken‐ichi Hosoya · 2015 · Journal of Pharmaceutical Sciences
  10. Antioxidant and Renoprotective Effects of Spirogyra neglecta (Hassall) Kützing Extract in Experimental Type 2 Diabetic Rats
    Atcharaporn Ontawong, Naruwan Saowakon, Pornpun Vivithanaporn, Anchalee Pongchaidecha, Narissara Lailerd, Doungporn Amornlerdpison, Anusorn Lungkaphin, Chutima Srimaroeng · 2013 · BioMed Research International
  11. Protein expression of kidney and liver bilitranslocase in rats exposed to mercuric chloride—A potential tissular biomarker of toxicity
    Mara S. Trebucobich, María Herminia Hazelhoff, Alberto Antonio Chevalier, Sabina Passamonti, Anabel Brandoni, Adriana M. Torres · 2013 · Toxicology Letters
  12. Impaired Insulin Signaling Affects Renal Organic Anion Transporter 3 (Oat3) Function in Streptozotocin-Induced Diabetic Rats
    Anusorn Lungkaphin, Phatchawan Arjinajarn, Anchalee Pongchaidecha, Chutima Srimaroeng, Lisa Chatsudthipong, Varanuj Chatsudthipong · 2014 · PLoS ONE · Retracted
  13. Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2
    Haoxun Wang, Da Zhong Xu, May Fern Toh, Alan C. Pao, Guofeng You · 2015 · Biochemical Pharmacology
  14. Drug Transporter Function—Implications in CKD
    Michael H. Schwenk, Amy Barton Pai · 2016 · Advances in Chronic Kidney Disease
  15. Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant Receptors
    Wei Wu, Kevin T. Bush, Henry C. Liu, Christopher Zhu, Ruben A Abagyan, Sanjay K. Nigám · 2015 · Drug Metabolism and Disposition
  16. Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5′-Adenosine Monophosphate-Activated Protein Kinase (AMPK)
    David J. Edmonds, Daniel W. Kung, Amit S.S. Kalgutkar, Kevin J. Filipski, David C. Ebner, Shawn Cabral, Aaron C. T. Smith, Gary E. Aspnes, Samit K. Bhattacharya, Kris A. Borzilleri et al. · 2018 · Journal of Medicinal Chemistry
  17. α-Ketoglutarate-related inhibitors of HIF prolyl hydroxylases are substrates of renal organic anion transporters 1 (OAT1) and 4 (OAT4)
    Yohannes Hagos, Gunnar Schley, Johannes Schödel, Wolfgang Krick, Gerhard Burckhardt, Carsten Willam, Birgitta Christina Burckhardt · 2012 · Pflügers Archiv - European Journal of Physiology
  18. Renal Organic Cation and Anion Transport: From Physiology to Genes
    Douglas H. Sweet · 2010 · Elsevier eBooks
  19. A Simple High-Performance Liquid Chromatographic Method for the Simultaneous Determination of Monoamine Neurotransmitters and Relative Metabolites with Application in Mouse Brain Tissue
    Christine A. Farthing, Matthew S. Halquist, Douglas H. Sweet · 2014 · Journal of Liquid Chromatography & Related Technologies
  20. Transmembrane Peptide as Potent Inhibitor of Oligomerization and Function of Human Organic Anion Transporter 1
    Peng Duan, Shanshan Li, Guofeng You · 2010 · Molecular Pharmacology
  21. Drug Transporters At Brain Barriers
    Tamima Ashraf, Olena Kis, Nilasha Banerjee, Reina Bendayan · 2013 · Advances in experimental medicine and biology
  22. A novel SNP in the 5’ regulatory region of organic anion transporter 1 is associated with chronic kidney disease
    Chiao‐Yin Sun, Mai-Szu Wu, Chin-Chan Lee, Shu-Hong Chen, Kang‐Chieh Lo, Yau‐Hung Chen · 2018 · Scientific Reports
  23. Estrogen receptor α (ERα) indirectly induces transcription of human renal organic anion transporter 1 (OAT1)
    Anna Maria Euteneuer, Tamina Seeger‐Nukpezah, Hendrik Nolte, Maja Henjakovic · 2019 · Physiological Reports
  24. SGK1/Nedd4–2 signaling pathway regulates the activity of human organic anion transporters 3
    Haoxun Wang, Guofeng You · 2017 · Biopharmaceutics & Drug Disposition
  25. Active Hydrophilic Components of the Medicinal HerbSalvia miltiorrhiza(Danshen) Potently Inhibit Organic Anion Transporters 1 (Slc22a6) and 3 (Slc22a8)
    Li Wang, Douglas H. Sweet · 2012 · Evidence-based Complementary and Alternative Medicine
  26. Organic Anion Transporter 1 Is Inhibited by Multiple Mechanisms and Shows a Transport Mode Independent of Exchange
    Adam G. Hotchkiss, Tiandai Gao, Usman Khan, Liam Berrigan, Mansong Li, Leslie Ingraham, Ryan M. Pelis · 2015 · Drug Metabolism and Disposition
  27. “Target-Site” Drug Metabolism and Transport
    R. Foti, Rachel Fynvola Tyndale, Kristine L. P. Garcia, Douglas H. Sweet, Swati Nagar, Satish Sharan, Dan A. Rock · 2015 · Drug Metabolism and Disposition
  28. Use of Transgenic and Knockout Mouse Models to Assess Solute Carrier Transporter Function
    Marianne K. DeGorter, Richard B. Kim · 2011 · Clinical Pharmacology & Therapeutics
  29. Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates
    Jana Mandíková, Marie Volková, Petr Pávek, Michal Česnek, Zlatko Janeba, Vladimı́r Kubı́ček, František Trejtnar · 2013 · Toxicology
  30. Cumulative Organic Anion Transporter-Mediated Drug-Drug Interaction Potential of Multiple Components in Salvia Miltiorrhiza (Danshen) Preparations
    Li Wang, Jürgen Venitz, Douglas H. Sweet · 2014 · Pharmaceutical Research
  31. Effect of Korean Red Ginseng extracts on drug-drug interactions
    Se-Jin Kim, Seungmok Choi, Min Soo Kim, Chang-Min Park, Gyu‐Lee Kim, Si‐On Lee, Wonku Kang, Dong‐Kwon Rhee · 2017 · Journal of Ginseng Research
  32. Ischemia/Reperfusion-Inducible Protein Modulates the Function of Organic Cation Transporter 1 and Multidrug and Toxin Extrusion 1
    Qing Li, Hyekyung Yang, Xiujuan Peng, Dong Guo, Zhongqi Dong, James E. Polli, Yan Shu · 2013 · Molecular Pharmaceutics
  33. Diclofenac toxicity in susceptible bird species results from a combination of reduced glomerular filtration and plasma flow with subsequent renal tubular necrosis
    Bono Nethathe, John Kudakwashe Chipangura, Ibrahim Zubairu Hassan, Neil M. Duncan, Emmanuel Oluwasegun Adawaren, Lauren Havenga, Vinny Naidoo · 2021 · PeerJ
  34. Intracellular prostaglandin E2 mediates cisplatin-induced proximal tubular cell death
    Ana B. Fernández‐Martínez, Selma Benito Martínez, Francisco Javier Lucio-Cazaña · 2015 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  35. Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions
    Jason T. Anderson, Kevin M. Huang, Maryam B. Lustberg, Alex Sparreboom, Shuiying Hu · 2020 · Reviews of physiology, biochemistry and pharmacology
  36. Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter—Organic anion transporter1 (Oat1)
    Valentina L. Kouznetsova, Igor F. Tsigelny, Megha A. Nagle, Sanjay K. Nigám · 2011 · Bioorganic & Medicinal Chemistry
  37. Organic anion transporter 2 transcript variant 1 shows broad ligand selectivity when expressed in multiple cell lines
    Adam G. Hotchkiss, Liam Berrigan, Ryan M. Pelis · 2015 · Frontiers in Pharmacology
  38. Organic Anion Transporter 5 Renal Expression and Urinary Excretion in Rats with Vascular Calcification
    María Herminia Hazelhoff, Romina Paula Bulacio, Adriana M. Torres · 2013 · BioMed Research International
  39. Serum- and glucocorticoid-inducible kinase sgk2 stimulates the transport activity of human organic anion transporters 1 by enhancing the stability of the transporter.
    Da Zhong Xu, Haozhe Huang, May Fern Toh, Guofeng You · 2016 · Europe PMC (PubMed Central)
  40. Construction and Evaluation of a Novel Organic Anion Transporter 1/3 CRISPR/Cas9 Double-Knockout Rat Model
    Xueyan Gou, Fenglin Ran, Jinru Yang, Yanrong Ma, Xinan Wu · 2022 · Pharmaceutics
  41. Functional characterization and comparison of human and mouse organic anion transporter 1 as drugs and pesticides uptake carrier
    Saskia Flörl, Annett Kühne, Yohannes Hagos · 2022 · European Journal of Pharmaceutical Sciences
  42. In Vitro Screening of Three Commercial Cannabis-Based Products on ATP-Binding Cassette and Solute-Carrier Transporter Function
    Lyndsey L. Anderson, Maia G. Etchart, Laura MacNair, M. Hunter Land, Irina Mosesova, Marcel O. Bonn‐Miller, Jonathon Carl Arnold · 2020 · Cannabis and Cannabinoid Research
  43. Protein kinase C regulates organic anion transporter 1 through phosphorylating ubiquitin ligase Nedd4–2
    Zhou Yu, Chenchang Liu, Jinghui Zhang, Zhengxuan Liang, Guofeng You · 2021 · BMC Molecular and Cell Biology
  44. Transcriptome-based reconstructions from the murine knockout suggest involvement of the urate transporter, URAT1 (slc22a12), in novel metabolic pathways
    Satish A. Eraly, Henry C. Liu, Neema Jamshidi, Sanjay K. Nigám · 2015 · Biochemistry and Biophysics Reports
  45. Renal Expression and Function of Oat1 and Oat3 in Rats with Vascular Calcification
    Romina Paula Bulacio, María Herminia Hazelhoff, Adriana M. Torres · 2012 · Pharmacology
  46. Interaction between rhein acyl glucuronide and methotrexate based on human organic anion transporters
    Yuan Yuan, Hua Qiang Yang, Linghua Kong, Yuan Li, Ping Li, Hongjian Zhang, Jianqing Ruan · 2017 · Chemico-Biological Interactions
  47. Evaluation of renal excretion and pharmacokinetics of furosemide in rats after acute exposure to high altitude at 4300 m
    Bingfeng Luo, Jing Li, Tao Yang, Wenbin Li, Juanhong Zhang, Chang Wang, Anpeng Zhao, Rong Wang · 2018 · Biopharmaceutics & Drug Disposition
  48. Substrate binding and lipid-mediated allostery in the human organic anion transporter 1 at the atomic-scale
    Angelika Janaszkiewicz, Ágota Tóth, Quentin Faucher, Hélène Arnion, Nicolas Védrenne, Chantal Barin‐Le Guellec, Pierre Marquet, Florent Di Meo · 2023 · Biomedicine & Pharmacotherapy
  49. Human organic anion transporter OAT1 is not responsible for glutathione transport but mediates transport of glutamate derivatives
    Yohannes Hagos, Gerhard Burckhardt, Birgitta Christina Burckhardt · 2012 · American Journal of Physiology-Renal Physiology
  50. Renal human organic anion transporter 3 increases the susceptibility of lymphoma cells to bendamustine uptake
    Yohannes Hagos, Philip Hundertmark, Volodymyr Shnitsar, Venkata V.V.R. Marada, Gerald Georg Wulf, Gerhard Burckhardt · 2014 · American Journal of Physiology-Renal Physiology
  51. Investigation of the differential transport mechanism of cinnabar and mercury containing compounds
    Yang Wang, Shaoyu Zhou, Honghong Ma, Jingshan Shi, Yuan‐Fu Lu · 2018 · Environmental Toxicology and Pharmacology
  52. Intracellular prostaglandin E2 contributes to hypoxia-induced proximal tubular cell death
    Coral García-Pastor, Selma Benito Martínez, Ricardo J. Bosch, Ana B. Fernández‐Martínez, Francisco Javier Lucio-Cazaña · 2021 · Scientific Reports
  53. Renal Handling of Amphotericin B and Amphotericin B-Deoxycholate and Potential Renal Drug-Drug Interactions with Selected Antivirals
    František Trejtnar, Jana Mandíková, Jana Kočíncová, Marie Volková · 2014 · Antimicrobial Agents and Chemotherapy
  54. Mechanisms of Drug Interactions II: Transport Proteins
    Catia Marzolini, Manuel Battegay, David J. Back · 2011 · Humana Press eBooks
  55. Contribution and expression of renal drug transporters in renal cell carcinoma
    Yawen Zuo, Tong Li, Shilei Yang, Xuyang Chen, Xufeng Tao, Deshi Dong, Fang Liu, Yanna Zhu · 2025 · Frontiers in Pharmacology
  56. Expression of renal Oat5 and NaDC1 transporters in rats with acute biliary obstruction
    Anabel Brandoni · 2015 · World Journal of Gastroenterology
  57. The renal transport of hippurate and protein‐bound solutes
    Rohit Kumar, Avinash Adiga, Joshua S. Novack, Alex Etinger, Lawrence Chinitz, James N. Slater, Henriëtte de Loor, Björn K.I. Meijers, Robert S. Holzman, Jerome Lowenstein · 2020 · Physiological Reports
  58. The activity of organic anion transporter-3: Role of dexamethasone
    Haoxun Wang, Chenchang Liu, Guofeng You · 2018 · Journal of Pharmacological Sciences
  59. Inhibitory interaction of flavonoids with organic anion transporter 3 and their structure-activity relationships for predicting nephroprotective effects
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  60. Folic acid reverses uric acid crystal-induced surface OAT1 internalization by inhibiting RhoA activity in uric acid nephropathy
    Xinlin Wu, Jianxiang Liu, Jianqing Zhang, Heng Liu, Miansheng Yan, Birong Liang, HONGBO XIE, Shijun Zhang, Baoguo Sun, Houming Zhou · 2016 · Molecular Medicine Reports
  61. The mechanistic links between insulin and human organic anion transporter 4
    Haoxun Wang, Jinghui Zhang, Guofeng You · 2018 · International Journal of Pharmaceutics
  62. Predicting Pharmacokinetics Variation of Faropenem Using a Pharmacometabonomic Approach
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  63. The Clinical Significance of Drug Transporters in Drug Disposition and Drug Interactions
    Thomas N. Thompson · 2011 · Springer eBooks
  64. Effect of Hepatic Impairment on the Pharmacokinetics of Baicalin in Rats: Critical Roles of Gut Microbiota and Hepatic Transporters
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  65. Quantitative Structure–Activity Relationship Analysis of a Series of Human Renal Organic Anion Transporter Inhibitors
    Yuhui Wei, Lili Xi, Xiaojun Yao, Jiazhong Li, Xinan Wu · 2012 · Archiv der Pharmazie
  66. Optimizing the Substrate Uptake Rate of Solute Carriers
    Klaus W. Schicker, Clemens V. Farr, Danila Boytsov, Michael Freissmuth, Walter Sandtner · 2022 · Frontiers in Physiology
  67. Prediction of the Renal Organic Anion Transporter 1 (OAT1)- Mediated Drug Interactions for LY404039, the Active Metabolite of Pomaglumetad Methionil
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  68. Glutathione Is a Low-Affinity Substrate of the Human Sodium-Dependent Dicarboxylate Transporter
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  69. Genetic polymorphism of the human organic solute carrier protein 1 (hOSCP1) gene in Japanese patients with non-viral liver carcinoma
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  70. The SUMO-Specific Protease Senp2 Regulates SUMOylation, Expression and Function of Human Organic Anion Transporter 3
    Haoxun Wang, Guofeng You · 2019 · Biochimica et Biophysica Acta (BBA) - Biomembranes
  71. Environmental contaminants modulate transport activity of zebrafish organic anion transporters Oat1 and Oat3
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  72. Organic Anion and Cation Transporters in Renal Elimination of Drugs
    Gerhard Burckhardt, Hermann Koepsell · 2012 · Elsevier eBooks
  73. Counter-flow suggests transport of dantrolene and 5-OH dantrolene by the organic anion transporters 2 (OAT2) and 3 (OAT3)
    Birgitta Christina Burckhardt, Maja Henjakovic, Yohannes Hagos, Gerhard Burckhardt · 2016 · Pflügers Archiv - European Journal of Physiology
  74. Differential Interaction of Dantrolene, Glafenine, Nalidixic Acid, and Prazosin with Human Organic Anion Transporters 1 and 3
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  75. Differences in Cerebral Distribution between Imipramine and Paroxetine via Membrane Transporters at the Rat Blood-Brain Barrier
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  76. Permeation of Fluorophore-Conjugated Phalloidin into Live Hair Cells of the Inner Ear Is Modulated by P2Y Receptors
    Benjamin R. Thiede, Jeffrey T. Corwin · 2013 · Journal of the Association for Research in Otolaryngology
  77. Organic Anion Transporters
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    Julie D. Tobin, Corie N. Robinson, Elliot S Luttrell-Williams, Greg M. Landry, Kenneth E. McMartin · 2023 · Toxicology Letters
  83. Excretory Processes in Toxicology: Drug Transporters in Drug Development
    KP. Van Ness, EJ Kelly · 2017 · Elsevier eBooks
  84. The Isoquinolone Derived Prolyl Hydroxylase Inhibitor ICA Is a Potent Substrate of the Organic Anion Transporters 1 and 3
    Kei Schulz, Yohannes Hagos, Gerhard Burckhardt, Gunnar Schley, Nicolai I. Burzlaff, Carsten Willam, Birgitta Christina Burckhardt · 2015 · The Nephron journals/Nephron journals
  85. Mechanisms of Drug Interactions II: Transport Proteins
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  86. ORGANIC ANION TRANSPORTERS. MOLECULAR DIVERSITY, STRUCTURE, CONTRIBUTION TO THE FUNCTIONING OF THE XENOBIOTIC BIOTRANSFORMATION SYSTEM IN ANIMALS (A REWIEW)
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  88. Inhibitory effects of apigenin and kaempferol on the essential solute carrier transporters
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  89. Expression and Function of Renal Organic Anion Transporters in Cholestasis
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  90. The Role of Drug Transporters in Statin-Induced Myopathy
    Michael J. Knauer · 2012 · Scholarship@Western (Western University)
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  92. Expression and phylogeny of multidrug resistance protein 2 and 4 in African white backed vulture (Gyps africanus)
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  93. Peptide Hormone Insulin Regulates Function, Expression, and SUMOylation of Organic Anion Transporter 3
    Jinghui Zhang, Guofeng You · 2021 · The AAPS Journal
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  95. Acetylation of L-leucine switches its carrier from the L-amino acid transporter (LAT) to organic anion transporters (OAT)
    Grant C. Churchill, Michael Leo Strupp, Tatiana Brémovà-Ertl, Mallory Factor, Marc C. Patterson, Frances M. Platt, Antony Galione · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  96. Maternal and Fetal Expression of ATP-Binding Cassette and Solute Carrier Transporters Involved in the Brain Disposition of Drugs
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  100. Interaction of the Atypical Tetracyclines Chelocardin and Amidochelocardin with Renal Drug Transporters
    Katharina Rox, Annett Kühne, Jennifer E. Herrmann, Rolf Jansen, Stephan Hüttel, Steffen Bernecker, Yohannes Hagos, Mark Brönstrup, Marc Stadler, Thomas Hesterkamp et al. · 2024 · ACS Pharmacology & Translational Science