The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
O6‐alkylguanine‐DNA alkyltransferase: Role in carcinogenesis and chemotherapy
Open accessAbstract
The DNA in human cells is continuously undergoing damage as consequences of both endogenous processes and exposure to exogenous agents. The resulting structural changes can be repaired by a number of systems that function to preserve genome integrity. Most pathways are multicomponent, involving incision in the damaged DNA strand and resynthesis using the undamaged strand as a template. In contrast, O6‐alkylguanine‐DNA alkyltransferase is able to act as a single protein that reverses specific types of alkylation damage simply by removing the offending alkyl group, which becomes covalently attached to the protein and inactivates it. The types of damage that ATase repairs are potentially toxic, mutagenic, recombinogenic and clastogenic. They are generated by certain classes of carcinogenic and chemotherapeutic alkylating agents. There is consequently a great deal of interest in this repair system in relation to both carcinogenesis and cancer chemotherapy. BioEssays 24:255–266, 2002. © 2002 Wiley Periodicals, Inc.; DOI 10.1002/bies.10063
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Cites
Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221
Repair of O6-alkylguanine by alkyltransferases
Pegg, A. E. (2000) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(00)00017-x · Cited by 576
Cited by
Repairing DNA-methylation damage
Sedgwick, B. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1312 · Cited by 388
Nuclear and mitochondrial DNA repair: similar pathways?
Larsen, N. B., Rasmussen, M., & Rasmussen, L. J. (2005) · Mitochondrion · doi:10.1016/j.mito.2005.02.002 · Cited by 289
CHEN, L., LI, X., LIU, L., YU, B., XUE, Y., & LIU, Y. (2015) · Oncology Reports · doi:10.3892/or.2015.3712 · Cited by 279
RetractedMechanisms of therapy-related carcinogenesis
Allan, J. M., & Travis, L. B. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1749 · Cited by 277
Lukin, M., & de los Santos, C. (2006) · Chemical Reviews · doi:10.1021/cr0404646 · Cited by 158
Wiewrodt, D., Nagel, G., Dreimüller, N., Hundsberger, T., Perneczky, A., & Kaina, B. (2008) · International Journal of Cancer · doi:10.1002/ijc.23219 · Cited by 114
Metadata
- Authors
- Margison, G. P., & Santibáñez‐Koref, M. F.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2002-02-28
- Volume
- 24
- Issue
- 3
- Pages
- 255-266
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2086303565
- Cited by
- 189
- References
- 2
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- green
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