Starting the protein synthesis machine: eukaryotic translation initiation
Abstract
The final assembly of the protein synthesis machinery occurs during translation initiation. This delicate process involves both ends of eukaryotic messenger RNAs as well as multiple sequential protein–RNA and protein–protein interactions. As is expected from its critical position in the gene expression pathway between the transcriptome and the proteome, translation initiation is a selective and highly regulated process. This synopsis summarises the current status of the field and identifies intriguing open questions. BioEssays 25:1201–1211, 2003 © 2003 Wiley Periodicals, Inc.
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mRNA stability and translation are controlled by a complex network of RNA/protein interactions and depend on the primary and secondary structures of mRNAs, their rates of translation, and the initiation of one of the various degradation mechanisms.
“mRNA stability and translation are controlled by a complex network of RNA/protein interactions and depend on the primary and secondary structures of mRNAs, their rates of translation, and the initiation of one of the various degradation mechanisms.[28][29][30][31]”
From Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells (2006) · cites this paper as [29]
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Aravind, L., & Koonin, E. V. (2000) · Genome Research · doi:10.1101/gr.10.8.1172 · Cited by 93 · see citing works
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Holtkamp, S., Kreiter, S., Selmi, A., Simon, P., Koslowski, M., Huber, C., Türeci, O., & Sahin, U. (2006) · Blood · doi:10.1182/blood-2006-04-015024 · Cited by 625 · see citing works
Translational control by changes in poly(A) tail length: recycling mRNAs
Weill, L., Belloc, E., Bava, F.-A., & Méndez, R. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2311 · Cited by 328 · see citing works
A comprehensive, quantitative, and genome-wide model of translation
Siwiak, M., & Zielenkiewicz, P. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000865 · Cited by 93 · see citing works
Surviving hypoxia by modulation of mRNA translation rate
Fähling, M. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00875.x · Cited by 54 · see citing works
The unique evolution of the programmed cell death 4 protein in plants
Cheng, S., Liu, R., & Gallie, D. R. (2013) · BMC Evolutionary Biology · doi:10.1186/1471-2148-13-199 · Cited by 22 · see citing works
- Authors
- Preiss, T., & W. Hentze, M.
- Affiliations
- Victor Chang Cardiac Research Institute (AU)
- Corresponding author
- Preiss, Thomas
- ORCID
- Preiss, Thomas
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2003-11-17
- Volume
- 25
- Issue
- 12
- Pages
- 1201-1211
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2079051847
- Cited by
- 216
- References
- 1
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 11 · 2015: 8 · 2014: 15 · 2013: 7 · 2012: 16
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BioEssays (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- translation initiation, eukaryotic translation, protein synthesis machinery, mRNA 5' cap, mRNA 3' end, RNA-protein interactions, protein-protein interaction, translational regulation, gene expression
- MeSH terms
- Animals, Fungal Proteins, Humans, Models, Biological, Models, Genetic, Peptide Chain Initiation, Translational, Protein Binding, Ribosomes, RNA, Messenger, Protein Biosynthesis, Codon, Initiator, 5' Untranslated Regions, Eukaryotic Initiation Factors
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