The role of chemoattraction in cancer metastases
Abstract
It has long been unclear as to why particular cancers preferentially metastasize to certain sites. The possibilities usually discussed involve differential survival and proliferation at these sites, or selective trapping with or without preferential homing. A recent report by Muller et al.(1) provides evidence for preferential homing of breast cancer to metastatic sites. The findings indicate that the chemokine receptors CXCR4 and CCR7 are found on breast cancer cells and their ligands are highly expressed at sites associated with breast cancer metastases. This results in chemotaxis, or directed migration of tumor cells from their primary site via the circulation to the preferential sites of metastases. The evidence for this model and its significance are reviewed here. BioEssays 23:674–676, 2001. © 2001 John Wiley & Sons, Inc.
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CXCR4 is expressed in tumour cell lines such as prostate carcinomas, B-cell lymphomas, astrogliomas and chronic lymphocytic leukaemias that also respond to CXCL12.
“The involvement of CXCR4 in metastasis is not limited to breast cancer, as CXCR4 is expressed in tumour cell lines (for example, prostate carcinomas, B-cell lymphomas, astrogliomas and chronic lymphocytic leukaemias) that also respond to CXCL12 (ref. 51).”
From Inflammation and cancer (2002) · cites this paper as [51]
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References 24 · Cited by 138
- Authors
- Moore, M. A. S.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Moore, Malcolm A.S.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2001-07-25
- Volume
- 23
- Issue
- 8
- Pages
- 674-676
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2043159830
- Cited by
- 138
- References
- 24
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 10
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BioEssays (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- metastasis, chemotaxis, chemokine receptors, CXCR4, CCR7, chemokine ligands, breast cancer, tumor cell homing, tumor cell migration
- MeSH terms
- Breast Neoplasms, Chemotactic Factors, Female, Humans, Male, Models, Biological, Neoplasm Metastasis, Chemokines, Receptors, Chemokine
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