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The ins and outs of lysophosphatidic acid signaling
Abstract
Lysophosphatidic acid (LPA) is a lipid mediator with a wide variety of biological actions, particularly as an inducer of cell proliferation, migration and survival. LPA binds to specific G‐protein‐coupled receptors and thereby activates multiple signal transduction pathways, including those initiated by the small GTPases Ras, Rho, and Rac. LPA signaling has been implicated in such diverse processes as wound healing, brain development, vascular remodeling and tumor progression. Knowledge of precisely how and where LPA is produced has long proved elusive. Excitingly, it has recently been discovered that LPA is generated from precursors by ‘autotaxin’, a once enigmatic exo‐phosphodiesterase implicated in tumor cell motility. Exogenous phospholipases D can also produce LPA, which may contribute to their toxicity. Here we review recent progress in our understanding of LPA bioactivity, signaling and synthesis. BioEssays 26:870–881, 2004. © 2004 Wiley Periodicals, Inc.
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Cited by
Two pathways for lysophosphatidic acid production
AOKI, J. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.06.005 · Cited by 448
NPP-type ectophosphodiesterases: unity in diversity
Stefan, C., Jansen, S., & Bollen, M. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.08.005 · Cited by 373
Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells
Pattabiraman, P. P., & Rao, P. V. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00317.2009 · Cited by 189
GSK-3 Is Activated by the Tyrosine Kinase Pyk2 during LPA1-mediated Neurite Retraction
Sayas, C. L., Ariaens, A., Ponsioen, B., & Moolenaar, W. H. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-07-0688 · Cited by 115
Self-citationUyama, T., Morishita, J., Jin, X.-H., Okamoto, Y., Tsuboi, K., & Ueda, N. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800453-jlr200 · Cited by 84
Metadata
- Authors
- Moolenaar, W. H., van Meeteren, L. A., & Giepmans, B. N. G.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2004-07-19
- Volume
- 26
- Issue
- 8
- Pages
- 870-881
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2111792754
- Cited by
- 571
- References
- 0
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
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