The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
A paternal environmental legacy: Evidence for epigenetic inheritance through the male germ line
Open accessAbstract
Literature on maternal exposures and the risk of epigenetic changes or diseases in the offspring is growing. Paternal contributions are often not considered. However, some animal and epidemiologic studies on various contaminants, nutrition, and lifestyle‐related conditions suggest a paternal influence on the offspring's future health. The phenotypic outcomes may have been attributed to DNA damage or mutations, but increasing evidence shows that the inheritance of environmentally induced functional changes of the genome, and related disorders, are (also) driven by epigenetic components. In this essay we suggest the existence of epigenetic windows of susceptibility to environmental insults during sperm development. Changes in DNA methylation, histone modification, and non‐coding RNAs are viable mechanistic candidates for a non‐genetic transfer of paternal environmental information, from maturing germ cell to zygote. Inclusion of paternal factors in future research will ultimately improve the understanding of transgenerational epigenetic plasticity and health‐related effects in future generations.
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Cites
Predicting Obesity in Young Adulthood from Childhood and Parental Obesity
Whitaker, R. C., Wright, J. A., Pepe, M. S., Seidel, K. D., & Dietz, W. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199709253371301 · Cited by 4,397
Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis
Hales, C. N., & Barker, D. J. P. (1992) · Diabetologia · doi:10.1007/bf00400248 · Cited by 3,309
Persistent epigenetic differences associated with prenatal exposure to famine in humans
Heijmans, B. T., Tobi, E. W., Stein, A. D., Putter, H., Blauw, G. J., Susser, E. S., Slagboom, P. E., & Lumey, L. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806560105 · Cited by 3,082
Environmental epigenomics and disease susceptibility
Jirtle, R. L., & Skinner, M. K. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2045 · Cited by 2,492
Self-citationTransposable elements: targets for early nutritional effects on epigenetic gene regulation
Waterland, R. A., & Jirtle, R. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5293-5300.2003 · Cited by 2,019 · cited 11×
“Following a landmark study by Waterland and Jirtle [8] using the agouti viable yellow (Avy) mouse model, the biological mechanisms underlying these associations in humans are now proposed to involve alterations in the epigenome, including DNA methylation, histone modifications, and transcription of non-coding RNAs.”
BackgroundMethodInfluentialStatistics notes: Absence of evidence is not evidence of absence
Altman, D. G., & Bland, J. M. (1995) · BMJ · doi:10.1136/bmj.311.7003.485 · Cited by 1,946
Oxidative stress and male infertility—a clinical perspective
Tremellen, K. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn004 · Cited by 1,507
Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting
Kaneda, M., Okano, M., Hata, K., Sado, T., Tsujimoto, N., Li, E., & Sasaki, H. (2004) · Nature · doi:10.1038/nature02633 · Cited by 1,387
Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring
Ng, S.-F., Lin, R. C. Y., Laybutt, D. R., Barres, R., Owens, J. A., & Morris, M. J. (2010) · Nature · doi:10.1038/nature09491 · Cited by 1,327
Distinctive chromatin in human sperm packages genes for embryo development
Hammoud, S. S., Nix, D. A., Zhang, H., Purwar, J., Carrell, D. T., & Cairns, B. R. (2009) · Nature · doi:10.1038/nature08162 · Cited by 1,320
Cited by
Parenting from before conception
Lane, M., Robker, R. L., & Robertson, S. A. (2014) · Science · doi:10.1126/science.1254400 · Cited by 289
Epigenetics in male reproduction: effect of paternal diet on sperm quality and offspring health
Schagdarsurengin, U., & Steger, K. (2016) · Nature Reviews Urology · doi:10.1038/nrurol.2016.157 · Cited by 222
Paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons
Vågerö, D., Pinger, P. R., Aronsson, V., & van den Berg, G. J. (2018) · Nature Communications · doi:10.1038/s41467-018-07617-9 · Cited by 150
A three-generation study on the association of tobacco smoking with asthma
Accordini, S., Calciano, L., Johannessen, A., Portas, L., Benediktsdóttir, B., Bertelsen, R. J., Bråbäck, L., Carsin, A.-E., Dharmage, S. C., Dratva, J., et al. (2018) · International Journal of Epidemiology · doi:10.1093/ije/dyy031 · Cited by 125
Exposure to childhood abuse is associated with human sperm DNA methylation
Roberts, A. L., Gladish, N., Gatev, E., Jones, M. J., Chen, Y., MacIsaac, J. L., Tworoger, S. S., Austin, S. B., Tanrikut, C., Chavarro, J. E., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0252-1 · Cited by 84
Metadata
- Authors
- Soubry, A., Hoyo, C., Jirtle, R. L., & Murphy, S. K.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2014-01-16
- Volume
- 36
- Issue
- 4
- Pages
- 359-371
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W1594472165
- Cited by
- 354
- References
- 126
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
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