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Dissecting the effects of antibiotics on horizontal gene transfer: analysis suggests a critical role of selection dynamics

Lopatkin, Allison J., Sysoeva, Tatyana A., You, Lingchong·2016·BioEssays
DOI 10.1002/bies.201600133PMC PMC6541220
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Abstract

Horizontal gene transfer (HGT) is a major mechanism responsible for the spread of antibiotic resistance. Conversely, it is often assumed that antibiotics promote HGT. Careful dissection of the literature, however, suggests a lack of conclusive evidence supporting this notion in general. This is largely due to the lack of well‐defined quantitative experiments to address this question in an unambiguous manner. In this review, we discuss the extent to which HGT is responsible for the spread of antibiotic resistance and examine what is known about the effect of antibiotics on the HGT dynamics. We focus on conjugation, which is the dominant mode of HGT responsible for spreading antibiotic resistance on the global scale. Our analysis reveals a need to design experiments to quantify HGT in such a way to facilitate rigorous data interpretation. Such measurements are critical for developing novel strategies to combat resistance spread through HGT.

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Cited by

Sorted by citations

Authors
Lopatkin, A. J., Sysoeva, T. A., & You, L.
Affiliations
Department of Biomedical Engineering Duke University Durham NC USA
Venue
BioEssays
Publisher
Wiley
Published
2016-10-04
Volume
38
Issue
12
Pages
1283-1292
ISSN
  • 0265-9247
  • 1521-1878
DOI
10.1002/bies.201600133
PMC
PMC6541220
Cited by
72
References
2
Language
en
Licence
Funders
  • Office of Naval Research (N00014‐12‐1‐0631)
  • National Science Foundation (1RO1GM098642, 1RO1GM110494)

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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