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The matrix‐degrading metalloproteinases
Abstract
The matrix‐degrading metalloproteinases are an intriguing family of enzymes that have evolved to digest specific extracellular matrix components. The expression of these enzymes is very highly regulated and can be controlled transcriptionally by a number of growth factors, tumor promoters, oncogenes, and hormones. It is suggested that the coordinated regulation of matrix metalloproteinases and their inhibitors by these agents modify the integrity of the extracellular matrix. These modifications may, at least in part, be responsible for mediating the effects of these factors on complex physiological processes.
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Cited by
Falk, E., Shah, P. K., & Fuster, V. (1995) · Circulation · doi:10.1161/01.cir.92.3.657 · Cited by 3,536
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Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525
Asthma: From Bronchoconstriction to Airways Inflammation and Remodeling
BOUSQUET, J., JEFFERY, P. K., BUSSE, W. W., JOHNSON, M., & VIGNOLA, A. M. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.5.9903102 · Cited by 1,702
Schönbeck, U., Mach, F., & Libby, P. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.7.3340 · Cited by 595
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Jenkins, G. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00425-0 · Cited by 560
Metadata
- Authors
- Matrisian, L. M.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 1992-07
- Volume
- 14
- Issue
- 7
- Pages
- 455-463
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2095498651
- Cited by
- 1,364
- References
- 0
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
