The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Curcumin in inflammatory diseases
Abstract
Curcumin (diferuloylmethane), a yellow coloring agent extracted from turmeric is also used as a remedy for the treatment and prevention of inflammatory diseases. Acute and chronic inflammation is a major factor in the progression of obesity, type II diabetes, arthritis, pancreatitis, cardiovascular, neurodegenerative and metabolic diseases, as well as certain types of cancer. Turmeric has a long history of use in Ayurvedic medicine for the treatment of inflammatory disorders. Recent studies on the efficacy and therapeutic applicability of turmeric have suggested that the active ingredient of tumeric is curcumin. Further, compelling evidence has shown that curcumin has the ability to inhibit inflammatory cell proliferation, invasion, and angiogenesis through multiple molecular targets and mechanisms of action. Curcumin is safe, non‐toxic, and mediates its anti‐inflammatory effects through the down‐regulation of inflammatory transcription factors, cytokines, redox status, protein kinases, and enzymes that all promote inflammation. In addition, curcumin induces apoptosis through mitochondrial and receptor‐mediated pathways, as well as activation of caspase cascades. In the current study, the anti‐inflammatory effects of curcumin were evaluated relative to various chronic inflammatory diseases. Based on the available pharmacological data obtained from in vitro and in vivo research, as well as clinical trials, an opportunity exists to translate curcumin into clinics for the prevention of inflammatory diseases in the near future. © 2012 BioFactors, 39(1):69–77, 2013
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Cited by
Curcumin, an active component of turmeric (Curcuma longa), and its effects on health
Kocaadam, B., & Şanlier, N. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1077195 · Cited by 1,207
Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?
He, Y., Yue, Y., Zheng, X., Zhang, K., Chen, S., & Du, Z. (2015) · Molecules · doi:10.3390/molecules20059183 · Cited by 608
Curcuminoid Treatment for Knee Osteoarthritis: A Randomized Double‐Blind Placebo‐Controlled Trial
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Schizophrenia, Curcumin and Minimizing Side Effects of Antipsychotic Drugs: Possible Mechanisms
Rabiee, R., Hosseini Hooshiar, S., Ghaderi, A., & Jafarnejad, S. (2023) · Neurochemical Research · doi:10.1007/s11064-022-03798-4 · Cited by 11
Metadata
- Authors
- Shehzad, A., Rehman, G., & Lee, Y. S.
- Venue
- BioFactors
- Publisher
- Wiley
- Published
- 2012-12-22
- Volume
- 39
- Issue
- 1
- Pages
- 69-77
- ISSN
- 0951-6433 (ISSN-L)
- 1872-8081
- OpenAlex
- W2067115104
- Cited by
- 311
- References
- 66
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- closed
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