The DOI matches its Crossref record.
The role of anthocyanins as an antioxidant under oxidative stress in rats
Abstract
Cyanidin 3‐O‐β‐d‐glucoside (C3G) is included in anthocyanins, and expected to have a potency to scavenge active oxygen species in vivo. Rats were fed a diet containing C3G (2 g/kg diet) for 14 days, and then subjected to hepatic ischemia‐reperfusion (I/R) as an oxidative stress model. I/R treatment elevated the liver thiobarbituric acid‐reactive substance concentration and the serum activities of marker enzymes for liver injury, and lowered the liver reduced glutathione concentration. Feeding C3G significantly suppressed these changes caused by hepatic I/R. These results indicate that C3G functions as a potent antioxidant in vivo under oxidative stress. To clarify the mechanism of action of C3G, we investigated the absorption and metabolism of C3G in rats. C3G appeared in the plasma immediately after the oral administration of C3G. Protocatechuic acid, which seems to be produced by the degradation of cyanidin, was also present in the plasma. In the liver and kidneys, C3G was metabolized to methylated form.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Anthocyanins: Natural Colorants with Health-Promoting Properties
He, J., & Giusti, M. M. (2010) · Annual Review of Food Science and Technology · doi:10.1146/annurev.food.080708.100754 · Cited by 1,637
Karlsen, A., Retterstøl, L., Laake, P., Paur, I., Kjølsrud-Bøhn, S., Sandvik, L., & Blomhoff, R. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.8.1951 · Cited by 384
Potential of herbs in skin protection from ultraviolet radiation
Korać, R., & Khambholja, K. (2011) · Pharmacognosy Reviews · doi:10.4103/0973-7847.91114 · Cited by 366
Song, J., He, Y., Luo, C., Feng, B., Ran, F., Xu, H., Ci, Z., Xu, R., Han, L., & Zhang, D. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105109 · Cited by 303
Qi, Q., Chu, M., Yu, X., Xie, Y., Li, Y., Du, Y., Liu, X., Zhang, Z., Shi, J., & Yan, N. (2023) · Food Reviews International · doi:10.1080/87559129.2022.2029479 · Cited by 280
Metadata
- Authors
- Tsuda, T., Horio, F., & Osawa, T.
- Venue
- BioFactors
- Publisher
- Wiley
- Published
- 2000-01
- Volume
- 13
- Issue
- 1-4
- Pages
- 133-139
- ISSN
- 0951-6433 (ISSN-L)
- 1872-8081
- OpenAlex
- W2009102536
- Cited by
- 162
- References
- 0
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The role of anthocyanins as an antioxidant under oxidative stress in rats. https://app.cochat.ai/papers/10.1002/biof.5520130122
- The paper
- Tsuda, T., Horio, F., & Osawa, T. (2000). The role of anthocyanins as an antioxidant under oxidative stress in rats. BioFactors. https://doi.org/10.1002/biof.5520130122
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
