Oligodendrogenesis: the role of iron
Open accessAbstract
Iron seems to be an essential factor in myelination and oligodendrocyte (OLGc) biology. However, the specific role of iron in these processes remains to be elucidated. Iron deficiency (ID) imposed to developing rats has been a relevant model to understand the role of iron in oligodendrogenesis and myelination. During early development ID causes specific changes in myelin composition, including a lower relative content of cholesterol, proteolipid protein (PLP), and myelin basic protein 21 (MBP21). These changes could be a consequence of the adverse effects of ID on OLGc development and function. We subsenquently studied the possible corrective effect of a single intracranial injection (ICI) of apotransferrin (aTf) on myelin formation in ID rats OLGc migration and differentiation after an ICI of aTf was evaluated at 3 days of age. ID increased the number of proliferating and undifferentiated cells in the corpus callosum (CC), while a single aTf injection reverts these effects, increasing the number of mature cells and myelin formation. Overall, results of a series of studies supports the concept that iron may affect OLGc development at early stages of embryogenesis rather than during late development. Myelin composition is altered by a limited iron supply, changes that can be reverted by a single injection of aTf.
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Large amounts of iron, needed for axon myelination, are present in oligodendrocytes.
“Large amounts of iron, needed for axon myelination, are present in oligodendrocytes.28,29”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [29]
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References 35 · Cited by 63
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- Authors
- Badaracco, M. E., Siri, M. V. R., & Pasquini, J. M.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Pasquini, Juana Maria
- Venue
- BioFactors
- Publisher
- Wiley
- Published
- 2010-03
- Volume
- 36
- Issue
- 2
- Pages
- 98-102
- ISSN
- 0951-6433 (ISSN-L)
- 1872-8081
- OpenAlex
- W2012115798
- Cited by
- 63
- References
- 35
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 5 · 2013: 2 · 2012: 2
- FWCI
- 0.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BioFactors (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Funders
- Universidad de Buenos Aires
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- iron deficiency, oligodendrogenesis, oligodendrocyte development, myelination, myelin composition, apotransferrin, intracranial injection, corpus callosum, proteolipid protein, cholesterol, embryonic development
- MeSH terms
- Iron Deficiencies, Animals, Cell Differentiation, Ferritins, Humans, Iron, Myelin Sheath, Oligodendroglia, Transferrin
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