The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Contextualizing context for synthetic biology – identifying causes of failure of synthetic biological systems
Open accessAbstract
Despite the efforts that bioengineers have exerted in designing and constructing biological processes that function according to a predetermined set of rules, their operation remains fundamentally circumstantial. The contextual situation in which molecules and single‐celled or multi‐cellular organisms find themselves shapes the way they interact, respond to the environment and process external information. Since the birth of the field, synthetic biologists have had to grapple with contextual issues, particularly when the molecular and genetic devices inexplicably fail to function as designed when tested in vivo. In this review, we set out to identify and classify the sources of the unexpected divergences between design and actual function of synthetic systems and analyze possible methodologies aimed at controlling, if not preventing, unwanted contextual issues.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Interdependence of Cell Growth and Gene Expression: Origins and Consequences
Scott, M., Gunderson, C. W., Mateescu, E. M., Zhang, Z., & Hwa, T. (2010) · Science · doi:10.1126/science.1192588 · Cited by 1,470
Growth Rate-Dependent Global Effects on Gene Expression in Bacteria
Klumpp, S., Zhang, Z., & Hwa, T. (2009) · Cell · doi:10.1016/j.cell.2009.12.001 · Cited by 703
Bacterial charity work leads to population-wide resistance
Lee, H. H., Molla, M. N., Cantor, C. R., & Collins, J. J. (2010) · Nature · doi:10.1038/nature09354 · Cited by 638
Structure and Flexibility Adaptation in Nonspecific and Specific Protein-DNA Complexes
Kalodimos, C. G., Biris, N., Bonvin, A. M. J. J., Levandoski, M. M., Guennuegues, M., Boelens, R., & Kaptein, R. (2004) · Science · doi:10.1126/science.1097064 · Cited by 543
Modular cell biology: retroactivity and insulation
Del Vecchio, D., Ninfa, A. J., & Sontag, E. D. (2008) · Molecular Systems Biology · doi:10.1038/msb4100204 · Cited by 519
Origins of specificity and promiscuity in metabolic networks
Carbonell, P., Lecointre, G., & Faulon, J.-L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.274050 · Cited by 87
Cited by
A brief history of synthetic biology
Cameron, D. E., Bashor, C. J., & Collins, J. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3239 · Cited by 933
Principles of genetic circuit design
Brophy, J. A. N., & Voigt, C. A. (2014) · Nature Methods · doi:10.1038/nmeth.2926 · Cited by 931
Gupta, A., Reizman, I. M. B., Reisch, C. R., & Prather, K. L. J. (2017) · Nature Biotechnology · doi:10.1038/nbt.3796 · Cited by 490
Synthetic analog computation in living cells
Daniel, R., Rubens, J. R., Sarpeshkar, R., & Lu, T. K. (2013) · Nature · doi:10.1038/nature12148 · Cited by 454
Mechanistic links between cellular trade-offs, gene expression, and growth
Weiße, A. Y., Oyarzún, D. A., Danos, V., & Swain, P. S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416533112 · Cited by 403
Metadata
- Authors
- Cardinale, S., & Arkin, A. P.
- Venue
- Biotechnology Journal
- Publisher
- Wiley
- Published
- 2012-05-31
- Volume
- 7
- Issue
- 7
- Pages
- 856-866
- ISSN
- 1860-6768 (ISSN-L)
- 1860-7314
- OpenAlex
- W2037913229
- Cited by
- 449
- References
- 6
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Contextualizing context for synthetic biology – identifying causes of failure of synthetic biological systems. https://app.cochat.ai/papers/10.1002/biot.201200085
- The paper
- Cardinale, S., & Arkin, A. P. (2012). Contextualizing context for synthetic biology – identifying causes of failure of synthetic biological systems. Biotechnology Journal. https://doi.org/10.1002/biot.201200085
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
