Mammalian Pericardium‐Based Bioprosthetic Materials in Xenotransplantation and Tissue Engineering
Abstract
Bioprosthetic materials based on mammalian pericardium tissue are the gold standard in reconstructive surgery. Their application range covers repair of rectovaginal septum defects, abdominoplastics, urethroplasty, duraplastics, maxillofacial, ophthalmic, thoracic and cardiovascular reconstruction, etc. However, a number of factors contribute to the success of their integration into the host tissue including structural organization, mechanical strength, biocompatibility, immunogenicity, surface chemistry, and biodegradability. In order to improve the material's properties, various strategies are developed, such as decellularization, crosslinking, and detoxification. In this review, the existing issues and long‐term achievements in the development of bioprosthetic materials based on the mammalian pericardium tissue, aimed at a wide‐spectrum application in reconstructive surgery are analyzed. The basic technical approaches to preparation of biocompatible forms providing continuous functioning, optimization of biomechanical and functional properties, and clinical applicability are described.
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GA increases ECM resistance to chemical and enzymatic degradation and alleviates immunogenicity of biological implants and enhances their longevity via masking immunogenic sites.
“This crosslinker increases ECM resistance to chemical and enzymatic degradation [198, 199] and, most importantly, alleviates the immunogenicity of biological implants and consequently enhances their longevity via masking immunogenic sites [198].”
From Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine (2023) · cites this paper as [198]
Neutralizing agents such as glycine, hyaluronic acid, heparin, and chitosan have shown promising results in detoxifying free aldehydes and reducing immunogenicity and calcification in GA-treated dECM scaffolds.
“Likewise, neutralizing agents such as glycine, hyaluronic acid, heparin, and chitosan have shown promising results in detoxifying free aldehydes and reducing immunogenicity and calcification in GA-treated dECM scaffolds [198, 202].”
From Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine (2023) · cites this paper as [198]
In typical concentrations, GA's high crosslinking density may interfere with tissue regeneration by inhibiting biodegradation of scaffolds even up to two years and is associated with a higher M1/M2 ratio, chronic inflammatory response, and FBR.
“Moreover, in typical concentrations, its high crosslinking density may interfere with tissue regeneration by inhibiting the biodegradation of scaffolds even up to two years and is associated with a higher M1/M2 ratio, chronic inflammatory response, and FBR [190, 198].”
From Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine (2023) · cites this paper as [198]
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References 169 · Cited by 30
- Authors
- Grebenik, E. A., Gafarova, E. R., Istranov, L. P., Istranova, E. V., Ma, X., Xu, J., Guo, W., Atala, A., & Timashev, P. S.
- Affiliations
- Sechenov University (RU)
- National Center for Nanoscience and Technology (CN)
- Wake Forest University Health Sciences (US)
- Russian Academy of Sciences (RU)
- Corresponding author
- Grebenik, Ekaterina A.
- ORCID
- Venue
- Biotechnology Journal
- Publisher
- Wiley
- Published
- 2020-03-04
- Volume
- 15
- Issue
- 8
- Pages
- e1900334-e1900334
- ISSN
- 1860-6768 (ISSN-L)
- 1860-7314
- OpenAlex
- W3008244971
- Cited by
- 30
- References
- 169
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 8 · 2022: 5 · 2021: 3 · 2020: 1
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biotechnology Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31761133013)
- Russian Science Foundation (18‐15‐00401)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- xenotransplantation, tissue engineering, reconstructive surgery, decellularization, crosslinking, detoxification, biocompatibility, immunogenicity, biodegradability, tissue mechanics, abdominoplasty, urethroplasty, duraplasty, maxillofacial reconstruction, thoracic reconstruction
- MeSH terms
- Animals, Biocompatible Materials, Humans, Mammals, Pericardium, Transplantation, Heterologous, Prostheses and Implants, Tissue Engineering
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