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Validity of the “two‐state” hypothesis for conformational transitions of proteins
Abstract
The theory, character, and properties of cooperative transitions are developed with special reference to the abrupt changes of state which occur in protein solutions. Comparisons of helix–coil processes and protein conformational reactions show that though cooperation dominates both of these processes, there are important differences. Tests of two types for the validity of the two‐state approximation are presented with specific applications to proteins. Available experimental evidence demonstrates that the thermally induced reversible transitions of ribonuclease, α‐chymotrypsin, and chymotrypsinogen A under conditions thus far examined are two‐state processes.
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Citations
Cited by
Stability of Protein Structure and Hydrophobic Interaction
Privalov, P. L., & Gill, S. J. (1988) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60377-0 · Cited by 1,303
Brandts, J. F., Halvorson, H. R., & Brennan, M. (1975) · Biochemistry · doi:10.1021/bi00693a026 · Cited by 1,113
Self-citationThe use of differential scanning calorimetry as a tool to characterize liposome preparations
Biltonen, R. L., & Lichtenberg, D. (1993) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(93)90062-8 · Cited by 414
Self-citationThe denatured state (the other half of the folding equation) and its role in protein stability
Shortle, D. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.1.8566543 · Cited by 403
Heteropolymer freezing and design: Towards physical models of protein folding
Pande, V. S., Grosberg, A. Y., & Tanaka, T. (2000) · Reviews of Modern Physics · doi:10.1103/revmodphys.72.259 · Cited by 284
Metadata
- Authors
- Lumry, R., Biltonen, R., & Brandts, J. F.
- Venue
- Biopolymers
- Publisher
- Wiley
- Published
- 1966-09
- Volume
- 4
- Issue
- 8
- Pages
- 917-944
- ISSN
- 0006-3525 (ISSN-L)
- 1097-0282
- OpenAlex
- W2090604290
- Cited by
- 359
- References
- 0
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Validity of the “two‐state” hypothesis for conformational transitions of proteins. https://app.cochat.ai/papers/10.1002/bip.1966.360040808
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- Lumry, R., Biltonen, R., & Brandts, J. F. (1966). Validity of the “two‐state” hypothesis for conformational transitions of proteins. Biopolymers. https://doi.org/10.1002/bip.1966.360040808
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