The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Calculation of binding isotherms for heterogeneous polymers
Abstract
The matrix method of statistical mechanics is used to calculate equilibria for the binding of small molecules to polymers. When there is only one kind of binding site the problem is simple; some examples are given for illustrative purposes. If, however, the binding sites are not all equivalent and the bound molecules interact or interfere with each other, the problem is no longer trivial, being formally analogous with calculation of the helix–coil transition equilibrium in a heterogeneous polypeptide. Particular difficulties arise when the sequence of binding sites is aperiodic; most naturally occurring materials fall in this class. The purpose of this paper is to point out that problems of this type are readily solved with good accuracy by use of random‐number methods on a high‐speed digital computer. One such calculation is presented for illustration. The methods developed are applicable to such systems as the binding of actinomycin, Hg–, and acridine dyes to DNA.
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Cites
THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS
Scatchard, G. (1949) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1949.tb27297.x · Cited by 19,778
Structural considerations in the interaction of DNA and acridines
Lerman, L. S. (1961) · Journal of Molecular Biology · doi:10.1016/s0022-2836(61)80004-1 · Cited by 2,243
Theory of the Phase Transition between Helix and Random Coil in Polypeptide Chains
Zimm, B. H., & Bragg, J. K. (1959) · The Journal of Chemical Physics · doi:10.1063/1.1730390 · Cited by 1,785
(1958) · Elsevier eBooks · doi:10.1016/c2013-0-12193-9 · Cited by 633
The interaction of aminoacridines with nucleic acids
PEACOCKE, A. R., & Skerrett, J. N. H. (1956) · Transactions of the Faraday Society · doi:10.1039/tf9565200261 · Cited by 530
Actinomycin binding to DNA: Mechanism and specificity
Gellert, M. F., Smith, C. E., Neville, D. M., & Felsenfeld, G. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80001-8 · Cited by 223
The Role of Deoxyribonucleic Acid in Ribonucleic Acid Synthesis
Kahan, E., Kahan, F. M., & Hurwitz, J. (1963) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)67999-8 · Cited by 118
Cited by
Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis
Fried, M., & Crothers, D. M. (1981) · Nucleic Acids Research · doi:10.1093/nar/9.23.6505 · Cited by 2,738
Self-citationChaires, J. B., Dattagupta, N., & Crothers, D. M. (1982) · Biochemistry · doi:10.1021/bi00260a005 · Cited by 938
Self-citationMcGhee, J. D. (1976) · Biopolymers · doi:10.1002/bip.1976.360150710 · Cited by 309
Wartell, R. M., Larson, J. E., & Wells, R. D. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42119-4 · Cited by 276
Horowitz, E. D., Engelhart, A. E., Chen, M. C., Quarles, K. A., Smith, M. W., Lynn, D. G., & Hud, N. V. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914172107 · Cited by 62
Metadata
- Authors
- Crothers, D. M.
- Venue
- Biopolymers
- Publisher
- Wiley
- Published
- 1968-04
- Volume
- 6
- Issue
- 4
- Pages
- 575-584
- ISSN
- 0006-3525 (ISSN-L)
- 1097-0282
- OpenAlex
- W2059090023
- Cited by
- 441
- References
- 7
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- closed
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