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Macromolecular binding
Abstract
Formulas for the free energy of binding to a macromolecule are obtained by thermodynamic and statistical mechanical methods, and it is shown that the free energy of binding is intimately related with the binding polynomial and Wyman's binding potential. The expression for the free energy of binding is applied to a number of cases of ligand‐induced conformational changes, cooperativity, association reactions, etc.
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Citations
Cited by
Protein interactions with urea and guanidinium chloride
Makhatadze, G. I., & Privalov, P. L. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90963-k · Cited by 623
Park, C., & Marqusee, S. (2005) · Nature Methods · doi:10.1038/nmeth740 · Cited by 283
Ligand binding to proteins: The binding landscape model
Miller, D. W., & Dill, K. A. (1997) · Protein Science · doi:10.1002/pro.5560061011 · Cited by 178
Kanaya, S., Oobatake, M., & Liu, Y. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32729 · Cited by 75
Metadata
- Authors
- Schellman, J. A.
- Venue
- Biopolymers
- Publisher
- Wiley
- Published
- 1975-05
- Volume
- 14
- Issue
- 5
- Pages
- 999-1018
- ISSN
- 0006-3525 (ISSN-L)
- 1097-0282
- OpenAlex
- W4248721956
- Cited by
- 377
- References
- 0
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- closed
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How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
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- CoChat. (2026). Citation check: Macromolecular binding. https://app.cochat.ai/papers/10.1002/bip.1975.360140509
- The paper
- Schellman, J. A. (1975). Macromolecular binding. Biopolymers. https://doi.org/10.1002/bip.1975.360140509
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
