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Correcting mass isotopomer distributions for naturally occurring isotopes
Abstract
In one method of metabolic flux analysis, simulated mass spectrometry data is fitted to measured mass distributions of metabolites that are isolated from cultures with defined feeding of 13 C‐labeled substrates. Doing so, simulated mass distributions must be corrected for the presence of naturally occurring isotopes. A method that was recently introduced for this purpose consists of consecutive correction steps for each isotope of each element in the considered compound. Here we show that all isotopes of each individual element must, however, be corrected in one single step. Furthermore, it is shown that the source of information with respect to isotopic compositions of the elements needs to be chosen with care. © 2002 Wiley Periodicals, Inc. Biotechnol Bioeng 80: 477–479, 2002.
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Cited by
A roadmap for interpreting 13C metabolite labeling patterns from cells
Buescher, J. M., Antoniewicz, M. R., Boros, L. G., Burgess, S. C., Brunengraber, H., Clish, C. B., DeBerardinis, R. J., Feron, O., Frezza, C., Ghesquiere, B., et al. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2015.02.003 · Cited by 629
Self-citationDu, D., Tan, L., Wang, Y., Peng, B., Weinstein, J. N., Wondisford, F. E., Su, X., & Lorenzi, P. L. (2019) · BMC Bioinformatics · doi:10.1186/s12859-019-2669-9 · Cited by 549
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Metadata
- Authors
- Van Winden, W. A., Wittmann, C., Heinzle, E., & Heijnen, J. J.
- Venue
- Biotechnology and Bioengineering
- Publisher
- Wiley
- Published
- 2002-09-24
- Volume
- 80
- Issue
- 4
- Pages
- 477-479
- ISSN
- 0006-3592 (ISSN-L)
- 1097-0290
- OpenAlex
- W2021441279
- Cited by
- 229
- References
- 0
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Van Winden, W. A., Wittmann, C., Heinzle, E., & Heijnen, J. J. (2002). Correcting mass isotopomer distributions for naturally occurring isotopes. Biotechnology and Bioengineering. https://doi.org/10.1002/bit.10393
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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