The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Simple constrained‐optimization view of acetate overflow in E. coli
Abstract
The production of acetate by aerobically growing E. coli is examined. The problem is formulated in terms of a flow network that has as its objective maximal ATP synthesis. It is found that when loads are imposed and flux constraints exist either at the level of NADH turnover rate or the activity of a key Krebs cycle enzyme, switching to acetate overflow is predicted. Moreover, the result found for the latter constraint can be shown to be formally equivalent to a correlation experimentally determined for the specific rate of acetate production by E. coli K‐12.
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Citations
Cites
Glutamate dehydrogenase from Escherichia coli: purification and properties
Sakamoto, N., Kotre, A. M., & Savageau, M. A. (1975) · Journal of Bacteriology · doi:10.1128/jb.124.2.775-783.1975 · Cited by 119
Cited by
Burgard, A. P., Pharkya, P., & Maranas, C. D. (2003) · Biotechnology and Bioengineering · doi:10.1002/bit.10803 · Cited by 1,256
Wolfe, A. J. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.1.12-50.2005 · Cited by 1,233
Varma, A., & Palsson, B. O. (1994) · Applied and Environmental Microbiology · doi:10.1128/aem.60.10.3724-3731.1994 · Cited by 1,051
Overflow metabolism in Escherichia coli results from efficient proteome allocation
Basan, M., Hui, S., Okano, H., Zhang, Z., Shen, Y., Williamson, J. R., & Hwa, T. (2015) · Nature · doi:10.1038/nature15765 · Cited by 785
The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli
Feist, A. M., & Palsson, B. Ø. (2008) · Nature Biotechnology · doi:10.1038/nbt1401 · Cited by 545
Metadata
- Authors
- Majewski, R. A., & Domach, M. M.
- Venue
- Biotechnology and Bioengineering
- Publisher
- Wiley
- Published
- 1990-03-25
- Volume
- 35
- Issue
- 7
- Pages
- 732-738
- ISSN
- 0006-3592 (ISSN-L)
- 1097-0290
- OpenAlex
- W1969529366
- Cited by
- 299
- References
- 1
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Majewski, R. A., & Domach, M. M. (1990). Simple constrained‐optimization view of acetate overflow in E. coli. Biotechnology and Bioengineering. https://doi.org/10.1002/bit.260350711
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
