A machine‐learning approach to calibrate generic Raman models for real‐time monitoring of cell culture processes

Tulsyan, Aditya; Schorner, Gregg; Khodabandehlou, Hamid; Wang, Tony; Coufal, Myra; Undey, Cenk

doi:10.1002/bit.27100

A machine‐learning approach to calibrate generic Raman models for real‐time monitoring of cell culture processes

The manufacture of biotherapeutic proteins consists of complex upstream unit operations requiring multiple raw materials, analytical techniques, and control strategies to produce safe and consistent products for patients. Raman spectroscopy is a ubiquitous multipurpose analytical technique in bio…