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Postoperative infection and natural killer cell function following blood transfusion in patients undergoing elective colorectal surgery
Abstract
The frequency of infection in 197 patients undergoing elective colorectal surgery and having either no blood transfusion, transfusion with whole blood, or filtered blood free from leucocytes and platelets was investigated in a prospective randomized trial. Natural killer cell function was measured before operation and 3, 7 and 30 days after surgery in 60 consecutive patients. Of the patients 104 required blood transfusion; 48 received filtered blood and 56 underwent whole blood transfusion. Postoperative infections developed in 13 patients transfused with whole blood (23 per cent, 9.5 per cent confidence interval 13–32 per cent), in one patient transfused with blood free from leucocytes and platelets (2 per cent, 9.5 per cent confidence interval 0.05–11 per cent) and in two non-transfusedpatients (2 per cent, 95 per cent conjidence interval 0.3-8per cent) (P < 0.01). Natural killer cell function was significantly (P < 0.001) impaired up to 30 days after surgery in patients transfused with whole blood. These data provide a strong case against the use of whole blood transfusion in patients undergoing elective colorectal surgery.
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Citations
Cited by
Kurz, A., Sessler, D. I., & Lenhardt, R. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605093341901 · Cited by 2,760
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Horowitz, M., Neeman, E., Sharon, E., & Ben-Eliyahu, S. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.224 · Cited by 487
Jensen, L. S., Kissmeyer-Nielsen, P., Wolff, B., & Qvist, N. (1996) · The Lancet · doi:10.1016/s0140-6736(96)06168-5 · Cited by 426
Self-citationDeleterious clinical effects of transfusion-associated immunomodulation: fact or fiction?
Vamvakas, E. C., & Blajchman, M. A. (2001) · Blood · doi:10.1182/blood.v97.5.1180 · Cited by 423
Mohri, Y., Tonouchi, H., Miki, C., Kobayashi, M., Kusunoki, M., & Mie Surgical Infection Research Group (2008) · World Journal of Surgery · doi:10.1007/s00268-008-9534-8 · Cited by 42
Metadata
- Authors
- Jensen, L. S., Andersen, A. J., Christiansen, P. M., Hokland, P., Juhl, C. O., Madsen, G., Mortensen, J., Meller-Nielsen, C., Hanberg-Sørensen, F., & Hokland, M.
- Venue
- Journal of British Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 1992-06-01
- Volume
- 79
- Issue
- 6
- Pages
- 513-516
- ISSN
- 0007-1323 (ISSN-L)
- 1365-2168
- OpenAlex
- W1984253491
- Cited by
- 558
- References
- 0
- FWCI
- 16.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Postoperative infection and natural killer cell function following blood transfusion in patients undergoing elective colorectal surgery. https://app.cochat.ai/papers/10.1002/bjs.1800790613
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- Jensen, L. S., Andersen, A. J., Christiansen, P. M., Hokland, P., Juhl, C. O., Madsen, G., Mortensen, J., Meller-Nielsen, C., Hanberg-Sørensen, F., & Hokland, M. (1992). Postoperative infection and natural killer cell function following blood transfusion in patients undergoing elective colorectal surgery. Journal of British Surgery. https://doi.org/10.1002/bjs.1800790613
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