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Evaluation of preoperative hepatic function in patients with hepatocellular carcinoma undergoing hepatectomy
Abstract
BACKGROUND: Postoperative hepatic failure is the leading cause of hospital mortality following hepatectomy for hepatocellular carcinoma (HCC). This prospective study was performed to identify the best test for assessment of the adequacy of hepatic functional reserve in patients with HCC before hepatectomy. METHODS: Between April 1989 and June 1993, 127 patients with HCC underwent hepatectomy. Each patient was evaluated before operation with the indocyanine green (ICG) clearance test, the aminopyrine breath test and the amino acid clearance test. RESULTS: Fourteen patients (11 per cent) died after hepatectomy. ICG retention at 15 min showed significant differences between patients who survived or died. By discriminant analysis, the safety limit of ICG retention at 15 min for major hepatectomy was 14 per cent and the relative risk of hospital mortality was 3. CONCLUSION: The ICG clearance test, expressed as the percentage of ICG retained at 15 min, is the best discriminating preoperative test for evaluating hepatic functional reserve in patients with HCC before hepatectomy.
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Cited by
EASL Clinical Practice Guidelines on the management of hepatocellular carcinoma
Sangro, B., Argemi, J., Ronot, M., Paradis, V., Meyer, T., Mazzaferro, V., Jepsen, P., Golfieri, R., Galle, P., Dawson, L., et al. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2024.08.028 · Cited by 985
One Thousand Fifty-Six Hepatectomies Without Mortality in 8 Years
Imamura, H. (2003) · Archives of Surgery · doi:10.1001/archsurg.138.11.1198 · Cited by 835
Ng, K. K. C., Chok, K. S. H., Chan, A. C. Y., Cheung, T. T., Wong, T. C. L., Fung, J. Y. Y., Yuen, J., Poon, R. T. P., Fan, S. T., & Lo, C. M. (2017) · British Journal of Surgery · doi:10.1002/bjs.10677 · Cited by 331
Self-citationWei, A. C., Tung-Ping Poon, R., Fan, S.-T., & Wong, J. (2003) · Journal of British Surgery · doi:10.1002/bjs.4018 · Cited by 315
Self-citationCucchetti, A., Ercolani, G., Vivarelli, M., Cescon, M., Ravaioli, M., La Barba, G., Zanello, M., Grazi, G. L., & Pinna, A. D. (2006) · Liver Transplantation · doi:10.1002/lt.20761 · Cited by 296
Metadata
- Authors
- Lau, H., Man, K., Fan, S.-T., Yu, W.-C., Lo, C.-M., & Wong, J.
- Venue
- British Journal of Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-09
- Volume
- 84
- Issue
- 9
- Pages
- 1255-1259
- ISSN
- 0007-1323 (ISSN-L)
- 1365-2168
- OpenAlex
- W1978621279
- Cited by
- 322
- References
- 0
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lau, H., Man, K., Fan, S.-T., Yu, W.-C., Lo, C.-M., & Wong, J. (1997). Evaluation of preoperative hepatic function in patients with hepatocellular carcinoma undergoing hepatectomy. British Journal of Surgery. https://doi.org/10.1002/bjs.1800840917
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