The DOI matches its Crossref record.
Segmental nature of the porcine liver and its potential as a model for experimental partial hepatectomy.
Abstract
BACKGROUND: In-depth knowledge of pig liver anatomy allows potential research into segmental liver resections and hepatic regeneration, as well as liver transplantation techniques. The segmental anatomy, however, remains largely unknown. This study aimed to delineate the segmental anatomy of the porcine liver in comparison with that of the human. METHODS: The segmental anatomy of the porcine liver was determined using acrylic injection casting of ex vivo pig livers, allowing the arterial, venous and biliary supply to be visualized directly. This was correlated using multi-slice computed tomography (CT) and three-dimensional reconstructions. RESULTS: Although the external morphology of the porcine liver differs from that of the human, the segmental anatomy is remarkably similar in term of its vascularity and biliary tree. CONCLUSION: Acrylic casting of the porcine liver accurately delineates the vascular and biliary anatomy, and is a useful tool for performing experimental liver surgery. The similarities between porcine and human segmental anatomy allow domestic swine to be used as a comparable model. Three-dimensional CT reconstructions can also accurately visualize the anatomy and may be used to perform virtual surgery, or to assess segmental volumes.
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Both human and porcine livers are divided into 8 similar segments.
“Despite these differences, both livers are divided into 8 similar segments, as determined by previous studies [[41], [42], [43]].”
From Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities (2024) · cites this paper as [43]
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Research works printed but not linked: 8
- Camprodon, 1977, Intrahepatic vascular division in the pig: basis for partial hepatectomies, Arch Surg, 112, 38, 10.1001/archsurg.1977.01370010040007 · DOI
- Filipponi, 1995, Segmental organization of the pig liver: anatomical basis of controlled partition for experimental grafting, Eur Surg Res, 27, 151, 10.1159/000129394 · DOI
- McIndoe, 1927, The bilaterality of the liver, Arch Surg, 15, 589, 10.1001/archsurg.1927.01130220092007 · DOI
- Healey, 1953, Anatomy of the biliary ducts within the human liver. Analysis of the prevailing pattern of branchings and the major variations of the biliary ducts, AMA Archives of Surgery, 66, 599, 10.1001/archsurg.1953.01260030616008 · DOI
- Couinaud, 1954, Lobes de segments hepatiques: notes sur l'architecture anatomique et chirurgicale du foie, Presse Med, 62, 709
- Bismuth, 1993, Segmental liver resection, Adv Surg, 26, 189
- Kahn, 1988, Partial hepatectomy and liver regeneration in pigs—the response to different resection sizes, J Surg Res, 45, 176, 10.1016/0022-4804(88)90062-5 · DOI · Paper page
- Glisson, 1654, Anatomia Hepatis
Cited by
Sorted by citations
Subtotal hepatectomy: a porcine model for the study of liver regeneration
Court, F. G., Laws, P. E., Morrison, C. P., Teague, B. D., Metcalfe, M. S., Wemyss-Holden, S. A., Dennison, A. R., & Maddern, G. J. (2004) · Journal of Surgical Research · doi:10.1016/j.jss.2003.08.007 · Cited by 60
Self-citationWang, Y., Zheng, Q., Sun, Z., Wang, C., Cen, J., Zhang, X., Jin, Y., Wu, B., Yan, T., Wang, Z., et al. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.03.013 · Cited by 55
Porcine liver anatomy applied to biomedicine
Eberlova, L., Maleckova, A., Mik, P., Tonar, Z., Jirik, M., Mirka, H., Palek, R., Leupen, S., & Liska, V. (2020) · Journal of Surgical Research · doi:10.1016/j.jss.2019.12.038 · Cited by 45
Hussein, K. H., Ahmadzada, B., Correa, J. C., Sultan, A., Wilken, S., Amiot, B., & Nyberg, S. L. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.06.001 · Cited by 28
“Despite these differences, both livers are divided into 8 similar segments, as determined by previous studies [41 – 43].”
Method
Metadata
- Authors
- Court, F. G., Wemyss-Holden, S. A., Morrison, C. P., Teague, B. D., Laws, P. E., Kew, J., Dennison, A. R., & Maddern, G. J.
- Affiliations
- Queen Elizabeth Hospital (AU)
- Leicester General Hospital (GB)
- Corresponding author
- Maddern, G J
- Venue
- British Journal of Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-02-10
- Volume
- 90
- Issue
- 4
- Pages
- 440-444
- ISSN
- 0007-1323 (ISSN-L)
- 1365-2168
- OpenAlex
- W2028496027
- Cited by
- 141
- References
- 0
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 10 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 8 · 2016: 11 · 2015: 12 · 2014: 6 · 2013: 6 · 2012: 10
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- British journal of surgery (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- 基礎心理学研究
- Topics
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Physical Sciences › Engineering › Biomedical Engineering › Anatomy and Medical Technology
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- porcine liver, partial hepatectomy, liver regeneration, liver transplantation, biliary tract, 3D CT reconstruction, virtual surgery, porcine model, segmental liver resection
- MeSH terms
- Animals, Biliary Tract, Female, Hepatectomy, Hepatic Artery, Hepatic Veins, Liver, Portal Vein, Swine, Tomography, X-Ray Computed
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