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Cited by 433

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Neoadjuvant chemotherapy for operable breast cancer

Mieog, J S D, van der Hage, J A, van de Velde, C J H·2007·British Journal of Surgery

Abstract

Background: Neoadjuvant chemotherapy for early breast cancer can avoid mastectomy by shrinkage of tumour volume. This review assesses the effectiveness of neoadjuvant chemotherapy on clinical outcome. Methods: All randomized trials comparing neoadjuvant and adjuvant chemotherapy for early breast cancer were reviewed systematically and meta-analyses were performed. Results: Fourteen studies randomizing 5500 women were eligible for analysis. Overall survival was equivalent in both groups. In the neoadjuvant group, the mastectomy rate was lower (relative risk 0·71 (95 per cent confidence interval (c.i.) 0·67 to 0·75)) without hampering local control (hazard ratio 1·12 (95 per cent c.i. 0·92 to 1·37)). Neoadjuvant chemotherapy was associated fewer adverse effects. Conclusion: Neoadjuvant chemotherapy is an established treatment option for early breast cancer.

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Crossref · 10.1002/bjs.5894

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Metadata

Authors
Mieog, J. S. D., van der Hage, J. A., & van de Velde, C. J. H.
Venue
British Journal of Surgery
Published
2007-08-13
Volume
94
Issue
10
Pages
1189-1200
ISSN
  • 0007-1323 (ISSN-L)
  • 1365-2168
OpenAlex
W2135753253
Cited by
433
References
5
FWCI
3.86
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.