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Cited by 257Pancreatic function and diabetesDiabetes and associated disordersDiabetes Management and Research

Optimal implantation site for pancreatic islet transplantation

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Merani, S, Toso, C, Emamaullee, J, Shapiro, A M J·2008·British Journal of Surgery
DOI 10.1002/bjs.6391
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Abstract

Background: Since the first report of successful pancreatic islet transplantation to reverse hyperglycaemia in diabetic rodents, there has been great interest in determining the optimal site for implantation. Although the portal vein remains the most frequently used site clinically, it is not ideal. About half of the islets introduced into the liver die during or shortly after transplantation. Although many patients achieve insulin independence after portal vein infusion of islets, in the long term most resume insulin injections. Methods: This review considers possible sites and techniques of islet transplantation in small and large animal models, and in humans. Metabolic, immunological and technical aspects are discussed. Results and conclusion: Many groups have sought an alternative site that might offer improved engraftment and long-term survival, together with reduced procedure-related complications. The spleen, pancreas, kidney capsule, peritoneum and omental pouch have been explored. The advantages and disadvantages of various sites are discussed in order to define the most suitable for clinical use and to direct future research.

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  • Several alternative transplantation sites to the liver have been proposed in humans, including the subcutaneous space, intramuscular space, and omentum.

    “In humans, several alternative transplantation sites to the liver have been proposed144, including the subcutaneous space145, intramuscular space146, and the omentum147,148.”

    From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [144]

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Authors
Merani, S., Toso, C., Emamaullee, J., & Shapiro, A. M. J.
Affiliations
University of Alberta (CA)
Corresponding author
Shapiro, A M J
ORCID
Venue
British Journal of Surgery
Publisher
Oxford University Press (OUP)
Published
2008-11-07
Volume
95
Issue
12
Pages
1449-1461
ISSN
  • 0007-1323 (ISSN-L)
  • 1365-2168
DOI
10.1002/bjs.6391
OpenAlex
W1980557101
Cited by
257
References
102
Citations by year
2026: 3 · 2025: 8 · 2024: 9 · 2023: 13 · 2022: 6 · 2021: 13 · 2020: 16 · 2019: 14 · 2018: 20 · 2017: 21 · 2016: 17 · 2015: 19 · 2014: 19 · 2013: 26 · 2012: 14
FWCI
2.22
Type
journal article
Language
en
Open access
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • British journal of surgery (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders
  • Medical Research
  • Swiss National Science Foundation
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
islet transplantation, implantation site, portal vein infusion, islet engraftment, islet survival, type 1 diabetes, insulin independence, spleen, kidney capsule, peritoneum, pancreas, animal models
MeSH terms
Adipose Tissue, Animals, Bone and Bones, Brain, Disease Models, Animal, Humans, Kidney, Male, Muscles, Pancreas, Portal Vein, Spleen, Testis, Thymus Gland, Islets of Langerhans Transplantation, Gastrointestinal Tract

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