Hypothalamic‐pituitary‐adrenal axis and depression symptom effects of an arginine vasopressin type 1B receptor antagonist in a one‐week randomized Phase 1b trial

Katz, David A.; Locke, Charles; Greco, Nicholas; Liu, Wei; Tracy, Katherine A.

doi:10.1002/brb3.628

Hypothalamic‐pituitary‐adrenal axis and depression symptom effects of an arginine vasopressin type 1B receptor antagonist in a one‐week randomized Phase 1b trial

Background Arginine vasopressin 1B receptor (V 1B ) antagonists may have utility for the treatment of major depressive disorder ( MDD ). Methods The V 1B antagonist ABT ‐436 ( N = 31) or matching placebo ( N = 20) was administered to MDD subjects for 7 days. The main study objectives were to asse…