Dissecting intratumoral myeloid cell plasticity by single cell RNA-seq

Song, Qianqian, Hawkins, Gregory A., Wudel, Leonard, Chou, Ping‐Chieh, Forbes, Elizabeth, Pullikuth, Ashok K., Liu, Liang, Jin, Guangxu +12 more·2019·Cancer Medicine

DOI 10.1002/cam4.2113

Cited by (167)

Items 101–167 of 167

A 23-gene multi-omics signature predicts prognosis and treatment response in non-small cell lung cancer
Yinxu Zhang, Siwang Wang, Xiaoyang Chen, Guangyu Zhang, Yuxi Wang, Xiaomei Liu · 2025 · Discover Oncology
Integrated multi-omics analysis reveals a glycolytic signature that predicts pan-cancer immune checkpoint inhibitor response and LDHA as a combinatorial target in fumarate hydratase-deficient renal cell carcinoma
Songyang Liu, Yunlong Yuan, Junzhe He, Yihan Zhou, Yuan Wang, Xinqi Ye, Jianfeng Wang, Jin Zhang · 2025 · Frontiers in Immunology
Iron overload in the tumor microenvironment induces CD8+ T cell ferroptosis and dysfunction
Zhenyu Lin, CHEN Huanpeng, Yujing Ke, Hanyue Xiao, Chao Li, Zilong Wu, Huixin Gao, Nanqi Huang, Lijuan Lu, Peng Sun et al. · 2026 · Nature Communications
Dual targeting of CDK6 and LSD1 is synergistic and overcomes differentiation blockade in AML
Lise M. Brault, Edwige Voisset, Mathieu Desaunay, Antonia Boudet, Paraskevi Kousteridou, Sébastien Letard, Nadine Carbuccia, Armelle Goubard, Rémy Castellano, Yves Collette et al. · 2025 · EMBO Molecular Medicine
Single-cell sequencing and network pharmacology coupled with molecular docking and experimental validation reveal the effects of YPFS on macrophages in stage I non-small cell lung cancer
Hongmin Li, Qitai Zhao, Li Yang, Le Wang, Fanglei Ye, Lei Yang, Peijun Zhang, Yi Zhang · 2026 · Cancer Immunology Immunotherapy
scGEM: Unveiling the Nested Tree-Structured Gene Co-Expressing Modules in Single Cell Transcriptome Data
Han Zhang, Xinghua Lu, Binfeng Lu, Lujia Chen · 2023 · Cancers
Identification of RNMT as an immunotherapeutic and prognostic biomarker: From pan-cancer analysis to lung squamous cell carcinoma validation
Shuqiang Huang, Cuiyu Tan, Jinzhen Zheng, Zhugu Huang, Zhihong Li, Ziyin Lv, Wanru Chen, Miaoqi Chen, Xiaojun Yuan, Cairong Chen et al. · 2024 · Immunobiology
Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives
Thomas Boyer, Céline Blaye, Nicolas Larmonier, Charlotte Domblides · 2022 · Cells
Establishment and validation of the prognostic risk model based on the anoikis-related genes in esophageal squamous cell carcinoma
Shasha Cao, Ming Li, Zhiying Cui, Yutong Li, Wei Niu, Weiwei Zhu, Junkuo Li, Lijuan Duan, Shumin Lun, Zhaowei Gao et al. · 2024 · Annals of Medicine
The Conjugation of Antibodies for the Simultaneous Detection of Surface Proteins and Transcriptome Analysis at a Single-Cell Level
Iivari Kleino, Eliisa Kekäläinen, Tapio Lönnberg · 2020 · Methods in molecular biology
A novel cancer-associated membrane signature predicts prognosis and therapeutic response for lung adenocarcinoma
Biao Tu, Jun Wu, Wei Zhang, Haitao Tang, Tenghui Dai, Bingfeng Xie · 2025 · Scientific Reports
YWHAG mediated epithelial-mesenchymal transition facilitates tumor progression and metastatic spread in non-small cell lung cancer
Kai Liu, Huiyong Han, Sha Huang, Lijiang Song, Jiuzhou Jiang, Dawei Zheng · 2025 · Cellular Signalling
CYP27A1 suppresses brain metastasis via ferroptosis in lung adenocarcinoma: a six-gene signature predicting the immunotherapy response and clinical outcomes
Xu Lu, Liyou Huang, Zihao Liu, Xiaojie Jiang, Linchun Wen · 2025 · Cancer Cell International
Cross-disease integration of single-cell RNA sequencing data from lung myeloid cells reveals TAM signature in in vitro model
Catarina Pinto, Jakub Widawski, Sophie Zahalka, Barbara Thaler, Linda C. Schuster, Samuel W. Lukowski, Fidel Ramírez, Iñigo Tirapu · 2025 · OncoImmunology
Platinum‐Based TREM2 Inhibitor Suppresses Tumors by Remodeling the Immunosuppressive Microenvironment
Tao Yang, Shuren Zhang, Hao Yuan, Ying Wang, Linxiang Cai, Hanhua Chen, Xiaoyu Wang, Dongfan Song, Xiaohui Wang, Zijian Guo et al. · 2022 · Angewandte Chemie
Identification of prognostic value of anoikis‐related gene score model combined with tumor microenvironment score models in esophageal squamous cell carcinoma
Moyan Zhang, Yicheng Liang, Peng Song · 2023 · The Journal of Gene Medicine
Decoding the single-cell landscape and intercellular crosstalk in the transplanted liver: a 4-dimension mouse model
Haitao Huang, Xueyou Zhang, Hui Chen, Feng Shi, Cheng Zhang, Ruihan Chen, Yimou Lin, Qinghua Ji, Qi Ling · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
Establishment and validation of the prognostic risk model based on the anoikis related genes in esophageal squamous cell carcinoma
Shasha Cao, Ming Li, Zhiying Cui, Yutong Li, Wei Niu, Weiwei Zhu, Junkuo Li, Lijuan Duan, Shumin Lun, Zhaowei Gao et al. · 2024 · Research Square
Diagnostic Efficacy of Tumor Markers AFP, CA19-9, and CEA in Hepatocellular Carcinoma Patients
Tufael, Auditi Kar, Md Haroon Or Rashid, Atiqur Rahman Sunny, António Raposo, Md. Saidul Islam, Md. Anower Hussain, Mohammad Anowar Hussen, Heesup Han, Henrique Douglas Melo Coutinho et al. · 2024 · Journal of Angiotherapy
A Cell-Cell Interaction Network Based Method for Identifying Lymph Node Metastasis and Characterizing Lung Cancer Progression
Xiong Li, Chuang Chen, Yixin Li, Yangkai Lin, Juan Zhou, Xiao Chen, Xuan Feng, Yuchao Luo, Haowen Chen · 2025 · IEEE Transactions on Computational Biology and Bioinformatics
Integrated multi-omics analysis reveals GPD1L-mediated dysregulation of glycerophospholipid metabolism facilitates the progression of lung adenocarcinoma
Yifu Sun, Yueren Yan, Yudi Zhou, Yuting Chen, Chaoying Liu, Yufang Bao, Yang Zhang, Han Han, Haiquan Chen · 2026 · Respiratory Research
MyD88-mediated chimaeric antigen receptor macrophages suppress brain metastasis using target-specific phagocytosis
Shih-Ying Wu, Abhishek Tyagi, Kerui Wu, Eleanor Cecile Smith, Qianqian Song, Sambad Sharma, Lance David Miller, W. Zhang, Bo‐Syong Pan, Hui‐Kuan Lin et al. · 2026 · Nature Biomedical Engineering
AGPAT3 reshapes tumor cell vulnerability to IFNγ-mediated ferroptosis and enhances immunotherapy efficacy through lipid remodeling
Chuan Liu, Chuanhui Hu, Jin-Lin Cheng, Duanfeng Xin, Su-Ji Jin, Weihong Tian, Shan Li, Yu-Zhi Jin, Yu Liu, Shu-Qiang Hao et al. · 2026 · Journal for ImmunoTherapy of Cancer
The Recurrent-Specific Regulation Network of Prognostic Stemness-Related Signatures in Low-Grade Glioma
Jin Li, Meng Zhou, Dan Yang Huang, Ruoyi Lin, Xiaomei Cui, Shaofeng Chen, Ying Yao, Shuyuan Xian, Siqiao Wang, Qing Fu et al. · 2023 · Disease Markers
Construction of continuously expandable single-cell atlases through integration of heterogeneous datasets in a generalized cell-embedding space
Lei Xiong, Kang Tian, Yuzhe Li, Qiangfeng Cliff Zhang · 2021 · Research Square
Correlation Between Tumor Differentiation and Biomarkers in Hepatocellular Carcinoma: Implications for Early Diagnosis and Treatment
Mr Tufael, Auditi Kar, Vijay Jagdish Upadhye, Atiqur Rahman Sunny, António Raposo, Md. Saidul Islam, Md Haroon Or Rashid, Mohammad Anowar Hussen, Heesup Han, Henrique Douglas Melo Coutinho et al. · 2024 · Preprints.org
MerTK-dependent efferocytosis by monocytic-MDSCs mediates resolution of post-lung transplant injury
Victoria Leroy, Denny Joseph Manual Kollareth, Zhenxiao Tu, Jeff Arni C. Valisno, Makena Woolet-Stockton, Biplab Kumar Saha, Amir M. Emtiazjoo, Mindaugas Rackauskas, Lyle L. Moldawer, Philip Alexander Efron et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Identification of cancer cell-intrinsic biomarkers associated with tumor progression and characterization of SFTA3 as a tumor suppressor in lung adenocarcinomas
Yu Chen Zhao, Chengcheng Zhou, Ling Zuo, Haoming Yan, Yuhan Gu, Hong Liu, Guiping Yu, Xiaorong Zhou · 2025 · BMC Cancer
The immunological and prognostic landscape of TFAP4 in cancer: A single-cell RNA sequencing perspective
Linghui Zhong, Zidong Feng, Feng Li, Honghui Zhao, Ziyu Zhang, Wenyang Zhang, Heiko Hermeking, Lei Shi · 2025 · Archives of Biochemistry and Biophysics
Disulfidptosis-associated gene signature predicts prognosis and radioresistance in NSCLC
Jianmin Liu, Juan Wang, Jia Wang, Meng Wu, Jinming Yu, Dawei Chen · 2025 · Translational Oncology
DDR1 as a key prognostic biomarker in non-small cell lung cancer: identification, validation, and potential therapeutic implications
Ren-Cai Lu, Qian Lü, XueQin Sun, Jian-Fang ZHANG, YeQian Cui, Hongwei Su, Dongdong Xv, ShaoBo Wang · 2025 · Frontiers in Immunology
Trannscriptomics and Immune Response in Human Cancer
Luiz Paulo Chaves, Camila Morais Melo, William Lautert-Dutra, André Luiz Caliari, Jeremy Andrew Squire · 2022 · Springer eBooks
Anoikis-related CTNND1 is associated with immuno-suppressive tumor microenvironment and predicts unfavorable immunotherapeutic outcome in non-small cell lung cancer
Yingchen Ni, Mengna Jiang, Yixuan Wu, Pei Xiao, Anqi Wu, Weiyi Xia, Can Tang, Xu Yang, Kai Tian, Hong Chen et al. · 2023 · Journal of Cancer
“Multiomics in precision medicine”
Konstantinos Katsos, Ashis Dhar, F. M. Moinuddin · 2024 · Elsevier eBooks
Deciphering the heterogeneity dominated by tumor-associated macrophages for survival prognostication and prediction of immunotherapy response in lung adenocarcinoma
Jiazheng Sun, Hehua Guo, Yalan Nie, Sirui Zhou, Yulan Zeng, Yalu Sun · 2024 · Scientific Reports
Validation of endoplasmic reticulum stress-related gene signature to predict prognosis and immune landscape of patients with non-small cell lung cancer
Yingying Cui, Xiaoli Zhou, Dan Zheng, Yumei Zhu · 2024 · Technology and Health Care
GATA2 induces a stem cell–like transcriptional program in macrophages that promotes an atherogenic phenotype
Amena Aktar, Angela M. Vrieze, Kiera Telesnicki, Paisley Cox‐Duvall, Matthew Arbolino, Rodney P. DeKoter, A. Dave Nagpal, Bryan Heit · 2025 · Journal of Leukocyte Biology
Dictionary learning allows model-free pseudotime estimation of transcriptomic data
Mona Rams, Tim Conrad · 2022 · BMC Genomics
Data-driven discovery of targets for bipotent anticancer drugs identifies Estrogen Related Receptor Alpha
Avinash D Sahu, Xiaoman Wang, Phillip B. Munson, Jan P.G. Klomp, Xiaoqing Wang, Shengqing Stan Gu, Gege Qian, Phillip B. Nicol, Zexian Zeng, Chenfei Wang et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
Deconvoluting sex-dependent dendritic cell-monocyte lineages in emphysematous lung tissue with bulk and single-cell RNA sequencing
Ji Shin, Ani W Manichaikul, Yong Huang, Zaid Obaida, Marie D. Burdick, Chunzi Song, Riley Hannan, Chaojie Yang, Ching Tan, Zhimin Zhang et al. · 2022 · Research Square
Figure S15 from Discovery of Targets for Immune–Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha
Avinash D Sahu, Xiaoman Wang, Phillip B. Munson, Jan P.G. Klomp, Xiaoqing Wang, Shengqing Stan Gu, Ya Han, Gege Qian, Phillip B. Nicol, Zexian Zeng et al. · 2023
Targeting TREM2 to disrupt the mitochondrial lipid and iron metabolism in cisplatin-resistant gastric cancer cells
Rui Wang, Quanquan Guo, Meimei Ma, Xiaohong Shi · 2023 · Research Square
Deciphering the immune heterogeneity dominated by RGS1+ TAMs with prognostic implications and identification of novel immunotherapeutic biomarker CD83 in lung adenocarcinoma
Jiazheng Sun, Hehua Guo, Yalan Nie, Sirui Zhou, Yulan Zeng, Yalu Sun · 2024 · Research Square
Global Trends in Research of Single Cell Sequence Associated with Cancer from 2011 to 2021: A Bibliometric Analysis
Xueliang Wu, Jianchun Fan, Tian Xiang Li · 2024 · SSRN Electronic Journal
Hallmarks of tumor-experienced T cells are absent in multiple myeloma patients from diagnosis through maintenance therapy
Carolyn Shasha, David Richard Glass, Ernest Moelhman, Laura Islas, Yuan Tian, Gregory Lee Szeto, Tao Peng, Xiaoling Song, Michelle A. Wurscher, Thomas F. Bumol et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Glutamine availability regulates cDC subsets in tissue
Graham P. Lobel, Nanumi Han, William A. Molina Arocho, Michal Silber, Jason Shoush, Michael Noji, Tsun Ki Jerrick To, Li Zhai, Nicholas P. Lesner, Marie Celeste Simon et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
M1 macrophage-related prognostic model by combining bulk and single-cell transcriptomic data in NSCLC
Zhe Liu, Liu Zhi Fang, Olutomilayo Olayemi Petinrin, Muhammad Toseef, Nanjun Chen, Zhongxu Zhu, Ka‐Chun Wong · 2024 · Exploration of Medicine
PU.1 regulation of type 1 dendritic cell function via NF-κB pathway in inhibition of non-small cell lung cancer progression
Tingting Wang, Yishuo Li, Qiongyu Duan, Chunlei Wang, Yixian Wang, Tianyu Hu · 2024 · Journal of Pharmaceutical Analysis
Integrated multi‐omics and machine learning reveal a gefitinib resistance signature for prognosis and treatment response in lung adenocarcinoma
Dong Zhou, Zhi Zheng, Yanqi Li, Jiao Zhang, Xiao Lan Lu, Hong Zheng, Jigang Dai · 2024 · IUBMB Life
Time-dependent chromatin maturation during 3D spheroid culture improves preclinical modeling of non-small cell lung cancer
Anaïs Darracq, Nicolas Sgarioto, Marielle Huot, Gabrielle McInnes, Antoine Méant, Alexandra Langford‐Avelar, Oscar David Villarreal, François Marois, Maxime Caron, Pascal St-Onge et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
ITGAM Upregulation in Acute Myeloid Leukemia Leads to Poor Prognosis Associated With Infiltration of Inhibitory Innate Immune Cells
Chen‐Chen Qin, Xiuzhen Tong, Chang Su, Zhenhai Zhou, Dong Zheng · 2025 · International Journal of Laboratory Hematology
Multimodal blood based profiling reveals insights into mechanisms of immunotherapy resistance
Samuel J. Wright, Izabella Zamora, Milan Parikh, Deepika Yeramosu, Marijana Ručević, Moshe Sade-Feldman, Thomas James LaSalle, Emily M. Blaum, Baolin Liu, Lynn Bi et al. · 2025 · medRxiv
GATA2 Induces a Stem Cell-Like Transcriptional Program in Macrophages that Promotes Atherogenesis
Amena Aktar, Angela M. Vrieze, Kiera Telesnicki, Paisley Cox‐Duvall, Matthew Arbolino, Rodney P. DeKoter, A. Dave Nagpal, Bryan Heit · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Pan-cancer landscape of cellular senescence heterogeneity reveals associations with prognosis and therapy response
Linyan Chen, Tongshu Yang, Zhiyuan Zhang, Yuqi Yang, Sidian Long, Manhua Wang, Hao Zeng · 2025 · Scientific Reports
Time-dependent epigenomic changes during 3D spheroid culture improve the preclinical modeling of non-small cell lung cancer
Anaïs Darracq, Nicolas Sgarioto, Marielle Huot, Gabrielle McInnes, Antoine Méant, Alexandra Langford‐Avelar, Oscar David Villarreal, François Marois, Maxime Caron, Pascal St-Onge et al. · 2025 · Research Square
Additional file 1 of Analysis of the effect of CCR7 on the microenvironment of mouse oral squamous cell carcinoma by single-cell RNA sequencing technology
Zengxu Wang, Keith Lough Kirkwood, Wang, Yao, Du, Weidong, shanfeng lin, Zhou, Wanhang, Cong Yan, Gao, Jiaxing, Li, Zhenning, Sun, Changfu et al. · 2024 · Figshare
Additional file 2 of Integrated analysis of single-cell and bulk RNA sequencing data reveals a pan-cancer stemness signature predicting immunotherapy response
Zhang, Zhen, Wang, Zi-Xian, Chen, Yan-Xing, Wu, Hao-Xiang, Yin, Ling, Zhao, Qi, Luo, Hui-Yan, Zhaolei Zeng, Miaozhen Qiu, Xu, Rui-Hua · 2022 · Figshare
Additional file 1 of Dictionary learning allows model-free pseudotime estimation of transcriptomic data
Mona Rams, Conrad, Tim O.F. · 2022 · Figshare
Additional file 1 of Integrated analysis of single-cell and bulk RNA sequencing data reveals a pan-cancer stemness signature predicting immunotherapy response
Zhang, Zhen, Wang, Zi-Xian, Chen, Yan-Xing, Wu, Hao-Xiang, Yin, Ling, Zhao, Qi, Luo, Hui-Yan, Zeng, Zhao-Lei, Miaozhen Qiu, Xu, Rui-Hua · 2022 · Figshare
Additional file 2 of Dictionary learning allows model-free pseudotime estimation of transcriptomic data
Mona Rams, Conrad, Tim O.F. · 2022 · Figshare
Targeting geranylgeranyl diphosphate synthase suppresses interleukin-1β-driven proliferation in lung squamous cell carcinoma by inhibiting Ras homolog family member A and Rac family small GTPase 1 geranylgeranylation
Liang Li, Xiaohan Zhao, Dachuan Liang, Wenyu Zhai, Dongyu Xu, Shuqin Dai, Junye Wang · 2026 · International Journal of Biological Macromolecules
Macrophage‐Mediated Cellular Communication Networks in Lung Squamous Cell Carcinoma and Adenocarcinoma Revealed by Single‐Cell Sequencing
Xiaoyu Zhang, Yunlong Zhao, Yingying Wang, Xiaomin Yu, Hongyu Xia, Meiru Li, Xiu‐An Yang · 2026 · Mediators of Inflammation
ScRNA-Seq: A way to reveal the potential mechanisms of metastasis in small cell lung cancer
Xi ling Guan, Dengxue Gan, Yong Wu, Ying Zhang · 2026 · Bulletin du Cancer
Ciblage thérapeutique de la protéine CDK6 dans les leucémies aiguës myéloïdes
Lise M. Brault · 2022 · theses.fr (ABES)
Integrative Transcriptomic Analysis Identifies COL3A1 as a Potential Tumor-Intrinsic Therapeutic Target in NSCLC
Kaicheng Zhou, Yanyang Nan, M C Li, Dongyue Hou, C Xu, Haiyan Yu, Jun Feng, Dianwen Ju, Ziyu Wang · 2026 · Biomedicines
Microbiome-derived hydroxyphenyl propanoates enhance antitumour immunity by potentiating gasdermin D activity in tumour-associated myeloid cells
Saif Sikdar, D Kim, Tie Wang, Sacha Benaoudia, Jahanara Rajwani, Kristofor K. Ellestad, Pauline Douglas, Růžena Filandrová, Theodore B. Verhey, Katrina I Ellestad et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
Integrative multi-omics analysis defines a macrophage-associated phospholipid metabolism signature linked to immune remodeling and prognosis in lung adenocarcinoma
Ling Wu, Pengfei Che, 柴立勋, Xiaofeng Luo, Chenhui Zhao, Yanlong Sun, Yuxuan Wang, Yunfei Wang · 2026 · Respiratory Research