IgLON cell adhesion molecules regulate synaptogenesis in hippocampal neurons
Abstract
IgLON cell adhesion molecules (CAMs) belonging to the immunoglobulin superfamily comprise of LAMP, neurotrimin (Ntm), OBCAM, and Kilon. In the present study, we performed the single and double transfection of IgLON gene constructs into hippocampal neurons in vitro and evaluated synaptic number. The quantitative analysis showed that the single over‐expression of LAMP or OBCAM increased synaptic number, while the over‐expression of Kilon reduced synaptic number and Ntm had no effects. The double over‐expression of Kilon‐Ntm, Kilon‐OBCAM, LAMP‐Ntm, and Ntm‐OBCAM decreased synaptic number and that of Kilon‐LAMP and LAMP‐OBCAM had no effect. These results suggest that IgLON CAMs participate in regulating synapse formation in hippocampal neurons. Copyright © 2009 John Wiley & Sons, Ltd.
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The MACROD2 locus was found significant in previous ASD GWAS but not supported in a larger study.
“Locus found significant in previous ASD GWAS 62 but not supported in larger study 63”
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References 16 · Cited by 117
- Authors
- Hashimoto, T., Maekawa, S., & Miyata, S.
- Affiliations
- Kyoto Institute of Technology (JP)
- Corresponding author
- Miyata, Seiji
- Venue
- Cell Biochemistry and Function
- Publisher
- Wiley
- Published
- 2009-08-26
- Volume
- 27
- Issue
- 7
- Pages
- 496-498
- ISSN
- 0263-6484 (ISSN-L)
- 1099-0844
- OpenAlex
- W1977595105
- Cited by
- 117
- References
- 16
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 20 · 2023: 8 · 2022: 7 · 2021: 8 · 2020: 6 · 2019: 11 · 2018: 10 · 2017: 7 · 2016: 7 · 2015: 4 · 2014: 9 · 2013: 2 · 2012: 4
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell Biochemistry and Function (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- synaptogenesis, hippocampal neurons, lamps, immunoglobulin superfamily, gene overexpression
- MeSH terms
- Animals, Cells, Cultured, Dendrites, Hippocampus, Neurons, Synapses, Transfection, Cell Adhesion Molecules, Neuronal, Rats, Wistar, Organogenesis, Rats
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