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Cited by 268Characterization and Applications of Magnetic NanoparticlesNMR spectroscopy and applicationsLanthanide and Transition Metal Complexes

Use of magnetic nanoparticles as nanosensors to probe for molecular interactions

Perez, J. Manuel, Josephson, Lee, Weissleder, Ralph·2004·ChemBioChem
DOI 10.1002/cbic.200300730
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Abstract

Biocompatible magnetic nanosensors have been designed to detect molecular interactions in biological media. Upon target binding, these nanosensors cause changes in the spin-spin relaxation times of neighboring water molecules, which can be detected by magnetic resonance (NMR/MRI) techniques. These magnetic nanosensors have been designed to detect specific mRNA, proteins, enzymatic activity, and pathogens (e.g., virus) with sensitivity in the low femtomole range (0.5-30 fmol).

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References 25 · Cited by 268

Authors
Perez, J. M., Josephson, L., & Weissleder, R.
Affiliations
Harvard University (US)
ORCID
Venue
ChemBioChem
Publisher
Wiley
Published
2004-02-26
Volume
5
Issue
3
Pages
261-264
ISSN
  • 1439-4227 (ISSN-L)
  • 1439-7633
DOI
10.1002/cbic.200300730
OpenAlex
W2031358898
Cited by
268
References
25
Citations by year
2025: 3 · 2024: 5 · 2023: 7 · 2022: 13 · 2021: 7 · 2020: 8 · 2019: 12 · 2018: 10 · 2017: 8 · 2016: 8 · 2015: 12 · 2014: 5 · 2013: 14 · 2012: 21
FWCI
12.91
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • ChemBioChem (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (P50-CA-86355, P50CA086355, CA101781, K01CA101781)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
  • Physical Sciences › Physics and Astronomy › Nuclear and High Energy Physics › NMR spectroscopy and applications
  • Physical Sciences › Materials Science › Materials Chemistry › Lanthanide and Transition Metal Complexes
Keywords
magnetic nanoparticles, nanosensors, molecular interactions, T2 relaxation, NMR detection, MRI detection, biocompatible nanoparticles, mRNA detection, protein detection, enzymatic activity detection, pathogen detection, virus detection
MeSH terms
Biocompatible Materials, Biopolymers, Enzymes, Ferric Compounds, Ligands, Magnetics, Magnetic Resonance Spectroscopy, Proteins, RNA, Messenger, Viruses, Water, Nanotechnology

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