The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Two‐Photon Fluorescent Probe for Lipid Raft Imaging: C‐Laurdan
Abstract
The lipid‐rafts hypothesis proposes that naturally occurring lipid aggregates exist in the plane of membrane that are involved in signal transduction, protein sorting, and membrane transport. To understand their roles in cell biology, a direct visualization of such domains in living cells is essential. For this purpose, 6‐dodecanoyl‐2‐(dimethylamino)naphthalene (laurdan), a membrane probe that is sensitive to the polarity of the membrane, has often been used. We have synthesized and characterized 6‐dodecanoyl‐2‐[N‐methyl‐N‐(carboxymethyl)amino]naphthalene (C‐laurdan), which has the advantages of greater sensitivity to the membrane polarity, a brighter two‐photon fluorescence image, and reflecting the cell environment more accurately than laurdan. Lipid rafts can be visualized by two‐photon microscopy by using C‐laurdan as a probe. Our results show that the lipid rafts cover 38 % of the cell surface.
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Citations
Cites
Extracellular ATP is generated by ATP synthase complex in adipocyte lipid rafts.
Kim, B.-W., Choo, H.-J., Lee, J.-W., Kim, J.-H., & Ko, Y.-G. (2004) · Experimental & Molecular Medicine · doi:10.1038/emm.2004.60 · Cited by 128
Cited by
Small-Molecule Two-Photon Probes for Bioimaging Applications
Kim, H. M., & Cho, B. R. (2015) · Chemical Reviews · doi:10.1021/cr5004425 · Cited by 1,047
Self-citationElucidating membrane structure and protein behavior using giant plasma membrane vesicles
Sezgin, E., Kaiser, H.-J., Baumgart, T., Schwille, P., Simons, K., & Levental, I. (2012) · Nature Protocols · doi:10.1038/nprot.2012.059 · Cited by 527
Order of lipid phases in model and plasma membranes
Kaiser, H.-J., Lingwood, D., Levental, I., Sampaio, J. L., Kalvodova, L., Rajendran, L., & Simons, K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908987106 · Cited by 482
Ratiometric Detection of Mitochondrial Thiols with a Two-Photon Fluorescent Probe
Lim, C. S., Masanta, G., Kim, H. J., Han, J. H., Kim, H. M., & Cho, B. R. (2011) · Journal of the American Chemical Society · doi:10.1021/ja205081s · Cited by 365
Self-citationSezgin, E., Levental, I., Grzybek, M., Schwarzmann, G., Mueller, V., Honigmann, A., Belov, V. N., Eggeling, C., Coskun, Ü., Simons, K., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2012.03.007 · Cited by 334
Metadata
- Authors
- Kim, H. M., Choo, H., Jung, S., Ko, Y., Park, W., Jeon, S., Kim, C. H., Joo, T., & Cho, B. R.
- Venue
- ChemBioChem
- Publisher
- Wiley
- Published
- 2007-03-13
- Volume
- 8
- Issue
- 5
- Pages
- 553-559
- ISSN
- 1439-4227 (ISSN-L)
- 1439-7633
- OpenAlex
- W2083656435
- Cited by
- 247
- References
- 1
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kim, H. M., Choo, H., Jung, S., Ko, Y., Park, W., Jeon, S., Kim, C. H., Joo, T., & Cho, B. R. (2007). A Two‐Photon Fluorescent Probe for Lipid Raft Imaging: C‐Laurdan. ChemBioChem. https://doi.org/10.1002/cbic.200700003
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