O‐Methyltransferase Is Shared between the Pentose Phosphate and Shikimate Pathways and Is Essential for Mycosporine‐Like Amino Acid Biosynthesis in Anabaena variabilis ATCC 29413

Pope, Matthew A.; Spence, Edward; Seralvo, Valentina; Gacesa, Ranko; Heidelberger, Sibylle; Weston, Andrew J.; Dunlap, Walter C.; Shick, J. Malcolm; Long, Paul F.

doi:10.1002/cbic.201402516

O‐Methyltransferase Is Shared between the Pentose Phosphate and Shikimate Pathways and Is Essential for Mycosporine‐Like Amino Acid Biosynthesis in Anabaena variabilis ATCC 29413

The parent core structure of mycosporine‐like amino acids (MAAs) is 4‐deoxygadusol, which, in cyanobacteria, is derived from conversion of the pentose phosphate pathway intermediate sedoheptulose 7‐phosphate by the enzymes 2‐ epi ‐5‐ epi valiolone synthase ( EVS ) and O‐methyltransferase ( OMT ).…