Chronic Central Adrenal Insufficiency in a Patient With Remote Traumatic Brain Injury and an Apparently Adequate Standard‐Dose ACTH Response: A Case Report
Open accessAbstract
In patients with a remote history of traumatic brain injury, central adrenal insufficiency may remain unrecognized for decades. An apparently adequate response to standard‐dose ACTH stimulation should not preclude further evaluation of the hypothalamic–pituitary–adrenal axis when clinical and biochemical findings continue to suggest adrenal insufficiency.
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Cites
Schneider, H. J., Kreitschmann-Andermahr, I., Ghigo, E., Stalla, G. K., & Agha, A. (2007) · JAMA · doi:10.1001/jama.298.12.1429 · Cited by 549 · see citing works
Corticotropin tests for hypothalamic-pituitary- adrenal insufficiency: a metaanalysis
Kazlauskaite, R., Evans, A. T., Villabona, C. V., Abdu, T. A. M., Ambrosi, B., Atkinson, A. B., Choi, C. H., Clayton, R. N., Courtney, C. H., Gonc, E. N., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0710 · Cited by 385 · see citing works
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Prevalence and predictive factors of post-traumatic hypopituitarism
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Neuroendocrine Disruptions Following Head Injury
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- Authors
- Kageyama, K., Sato, K., Yamagata, S., Tasso, M., Nakada, Y., & Sawada, S.
- Affiliations
- Tohoku Medical and Pharmaceutical University (JP)
- Corresponding author
- Kageyama, Kazunori
- Venue
- Clinical Case Reports
- Publisher
- Wiley
- Published
- 2026-09-24
- Volume
- 14
- Issue
- 10
- Pages
- e73582-e73582
- ISSN
- 2050-0904 (ISSN-L)
- PMC
- PMC13612852
- OpenAlex
- W7214327275
- Cited by
- 0
- References
- 7
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Clinical Case Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- secondary adrenal insufficiency, traumatic brain injury, ACTH stimulation test, hypothalamic-pituitary-adrenal axis, delayed diagnosis, adrenal insufficiency
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