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The Advantage of Being Virtual—Target‐Induced Adaptation and Selection in Dynamic Combinatorial Libraries
Open accessAbstract
Numerical simulations are presented that describe the adaptive behavior of simple dynamic combinatorial libraries (DCLs) upon addition of a target. By studying the effect of various parameters such as the network topology, the initial concentrations, the association constants, and the binding affinities, general characteristics of such systems were derived. It is shown that the adaptation may lead to the amplification of molecules with a high affinity to the target, but only for specific boundary conditions. Furthermore, it is demonstrated that the selection process can be refined by using an evolutionary approach. These results are of importance for the design of selection experiments with DCLs.
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Cited by
Dynamic Combinatorial Chemistry
Corbett, P. T., Leclaire, J., Vial, L., West, K. R., Wietor, J.-L., Sanders, J. K. M., & Otto, S. (2006) · Chemical Reviews · doi:10.1021/cr020452p · Cited by 1,922
Ludlow, R. F., & Otto, S. (2008) · Chem. Soc. Rev. · doi:10.1039/b611921m · Cited by 592
Herrmann, A. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60336a · Cited by 351
Evolution of Dynamic Combinatorial Chemistry
Cougnon, F. B. L., & Sanders, J. K. M. (2012) · Accounts of Chemical Research · doi:10.1021/ar200240m · Cited by 316
A Bistable Switch in Dynamic Thiodepsipeptide Folding and Template‐Directed Ligation
Mukherjee, R., Cohen‐Luria, R., Wagner, N., & Ashkenasy, G. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201503898 · Cited by 46
Metadata
- Authors
- Severin, K.
- Venue
- Chemistry – A European Journal
- Publisher
- Wiley
- Published
- 2004-05-07
- Volume
- 10
- Issue
- 10
- Pages
- 2565-2580
- ISSN
- 0947-6539 (ISSN-L)
- 1521-3765
- OpenAlex
- W2014198696
- Cited by
- 177
- References
- 0
- FWCI
- 11.86
- Type
- journal article
- Language
- en
- Open access
- green
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