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A Ruthenium Antimetastasis Agent Forms Specific Histone Protein Adducts in the Nucleosome Core
Open accessAbstract
His-tones are not ruth-less: A ruthenium anticancer agent, RAPTA-C, was found to associate with chromatin in cancer cells and to form stable, well-defined adducts in the nucleosome core at specific histone protein sites (see picture). This illuminates the macromolecular binding properties of this antimetastasis agent and indicates potential for developing metallodrugs for site-selective targeting of chromatin.
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Cited by
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Barry, N. P. E., & Sadler, P. J. (2013) · Chemical Communications · doi:10.1039/c3cc41143e · Cited by 717
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Kenny, R. G., & Marmion, C. J. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00271 · Cited by 636
Brunk, E., & Rothlisberger, U. (2015) · Chemical Reviews · doi:10.1021/cr500628b · Cited by 494
Meier-Menches, S. M., Gerner, C., Berger, W., Hartinger, C. G., & Keppler, B. K. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00332c · Cited by 425
Self-citationMetal-based drugs that break the rules
Allardyce, C. S., & Dyson, P. J. (2016) · Dalton Transactions · doi:10.1039/c5dt03919c · Cited by 308
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Metadata
- Authors
- Wu, B., Ong, M. S., Groessl, M., Adhireksan, Z., Hartinger, C. G., Dyson, P. J., & Davey, C. A.
- Venue
- Chemistry – A European Journal
- Publisher
- Wiley
- Published
- 2011-02-23
- Volume
- 17
- Issue
- 13
- Pages
- 3562-3566
- ISSN
- 0947-6539 (ISSN-L)
- 1521-3765
- OpenAlex
- W2086627300
- Cited by
- 174
- References
- 0
- FWCI
- 8.55
- Type
- journal article
- Language
- en
- Open access
- green
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- Wu, B., Ong, M. S., Groessl, M., Adhireksan, Z., Hartinger, C. G., Dyson, P. J., & Davey, C. A. (2011). A Ruthenium Antimetastasis Agent Forms Specific Histone Protein Adducts in the Nucleosome Core. Chemistry – A European Journal. https://doi.org/10.1002/chem.201100298
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