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Cited by 613

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Halogen Bonding in Organic Synthesis and Organocatalysis

Bulfield, David, Huber, Stefan M.·2016·Chemistry – A European Journal

Abstract

Halogen bonding is a noncovalent interaction similar to hydrogen bonding, which is based on electrophilic halogen substituents. Hydrogen‐bonding‐based organocatalysis is a well‐established strategy which has found numerous applications in recent years. In light of this, halogen bonding has recently been introduced as a key interaction for the design of activators or organocatalysts that is complementary to hydrogen bonding. This Concept features a discussion on the history and electronic origin of halogen bonding, summarizes all relevant examples of its application in organocatalysis, and provides an overview on the use of cationic or polyfluorinated halogen‐bond donors in halide abstraction reactions or in the activation of neutral organic substrates.

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Metadata

Authors
Bulfield, D., & Huber, S. M.
Venue
Chemistry – A European Journal
Publisher
Wiley
Published
2016-07-28
Volume
22
Issue
41
Pages
14434-14450
ISSN
  • 0947-6539 (ISSN-L)
  • 1521-3765
OpenAlex
W2552570031
Cited by
613
References
2
FWCI
39.85
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Halogen Bonding in Organic Synthesis and Organocatalysis. https://app.cochat.ai/papers/10.1002/chem.201601844
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Bulfield, D., & Huber, S. M. (2016). Halogen Bonding in Organic Synthesis and Organocatalysis. Chemistry – A European Journal. https://doi.org/10.1002/chem.201601844

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.