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Cited by 128Berberine and alkaloids researchHeart Failure Treatment and ManagementCardiac Fibrosis and Remodeling

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Cardiovascular effects of berberine in patients with severe congestive heart failure

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Marin ‐ NETO, J. A., Maciel, B. C., Secches, A. L., Gallo, L.·1988·Clinical Cardiology
DOI 10.1002/clc.4960110411
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Abstract

Abstract Berberine, an alkaloid of the protoberberine family, has been shown to have strong positive inotropic and peripheral resistance‐lowering effects in dogs with and without heart failure. To determine the acute cardiovascular effects of berberine in humans, 12 patients with refractory congestive heart failure were studied before and during berberine intravenous infusion at rates of 0.02 and 0.2 mg/kg per min for 30 minutes. The lower infusion dose produced no significant circulatory changes, apart from a reduction in heart rate (14%). The 0.2 mg/kg per min dose elicited several significant changes: (a) Decreases in systemic (48%, p>0.01) and pulmonary vascular resistance (41%, p>0.01), and in right atrium (28%, p>0.05) and left ventricular end‐diastolic pressures (32%, p>0.01). (b) Increases in cardiac index (45%, p>0.01), stroke index (45%, p>0.01), and LV ejection fraction measured by contrast angiography (56%, p>0.01). (c) Increases in hemodynamic and echocardiographic indices of LV performance: peak measured velocity of shorten: ing (45%, p>0.01), peak shortening velocity at zero load (41%, p>0.01), rate of development of pressure at developed isovolumic pressure of 40 mmHg (20%, p>0.01), percent fractional shortening (50%, p>0.01), and the mean velocity of circumferential fiber shortening (54%, p>0.01). (d) Decrease of arteriovenous oxygen difference (28%, p>0.05) with no changes in total body oxygen uptake, arterial oxygen tension, or hemoglobin dissociation properties. These salutary acute effects show that berberine markedly improved cardiac performance in patients with heart failure refractory to conventional medical therapy with digitalis and diuretics. The improvement is probably subsequent to peripheral vasodilatation and to inotropic stimulation. Significant untoward effects appear to be the development of ventricular tachycardia with “torsades de pointes” morphology, detected in 4 patients 1‐20 h after the infusion of berberine. This possible association requires further elucidation before the administration of berberine may be extended to other patients in heart failure.

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Research works printed but not linked: 7

  1. Maroko PR, 1982, Protoberberine alkaloids — a new family of inotropic agents (abstr), Circulation, 66, 137
  2. Krol R, 1982, Additive effects of berberine and ouabain on myocardial contractility (abstr), Clin Res, 30, 673‐A
  3. Vik‐Mo H, 1983, Beneficial effects of berberine on left ventricular function in dogs with heart failure (abstr), Clin Res, 31, 224‐A
  4. Zalewski A, 1983, Berberine, a new inotropic agent — distinction between its cardiac and peripheral responses (abstr), Clin Res, 31, 227‐A
  5. Krol R, 1982, Beneficial effects of berberine, a new positive inotropic agent, on digitalis‐induced ventricular arrhythmias (abstr), Circulation, 66, 56
  6. Ksiezycka E, 1983, Antiarrhythmic effects of berberine on aconitine‐induced ventricular and supraventricular arrhythmias (abstr), Clin Res, 312, 197‐A
  7. Ribeiro LGT, 1982, Beneficial effects of berberine on early mortality after experimental coronary artery occlusion in rats (abstr), Circulation, 66, 56

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Metadata

Authors
Marin ‐ NETO, J. A., Maciel, B. C., Secches, A. L., & Gallo, L.
Affiliations
Universidade de São Paulo (BR)
ORCID
Maciel, B. C.
Venue
Clinical Cardiology
Publisher
Wiley
Published
1988-04
Volume
11
Issue
4
Pages
253-260
ISSN
  • 0160-9289 (ISSN-L)
  • 1932-8737
DOI
10.1002/clc.4960110411
OpenAlex
W2063518321
Cited by
128
References
17
Citations by year
2026: 4 · 2025: 4 · 2024: 3 · 2023: 10 · 2022: 4 · 2021: 9 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 9 · 2015: 8 · 2014: 5 · 2013: 12 · 2012: 3
FWCI
0.42
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7614 d)
Locations
  • Clinical Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Fundação de Amparo à Pesquisa do Estado de São Paulo
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Berberine and alkaloids research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords
berberine, congestive heart failure, refractory heart failure, cardiovascular effects, inotropic effect, vasodilation, pulmonary vascular resistance, left ventricular ejection fraction, cardiac function, ventricular tachycardia, torsades de pointes, diuretic resistance, cardiac index, arteriovenous oxygen difference, intravenous infusion, adverse drug reactions
MeSH terms
Adult, Aged, Berberine, Berberine Alkaloids, Echocardiography, Electrocardiography, Female, Heart Failure, Hemodynamics, Humans, Male, Middle Aged, Tachycardia

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