Morning attenuation of endothelium‐dependent, flow‐mediated dilation in healthy young men: Possible connection to morning peak of cardiac events?
Open accessAbstract
Background and hypothesis : Brachial artery flow‐mediated dilation (FMD), a noninvasive, widely used clinical index of endothelial function and magnitude of FMD, has been reported to be closely related to many coronary risk factors and coronary atherosclerosis. However, there has been no study that examines the diurnal change of FMD. We designed this study to reveal the diurnal variation of FMD in healthy volunteers. Methods : We examined FMD in response to reactive hyperemia by high resolution ultrasound in 13 healthy young men (age 25–32) at four different times over the course of a day. Results : Mean measures of brachial artery FMD was 4.0% at 8:00, 5.3% at 12:00, 9.7% at 17:00, and 6.9% at 21:00 hours. Flow‐mediated dilation at 8:00 and at 12:00 hours was significantly lower than that at 17:00 (p <0.05). Conclusions : These results show that endothelial function has diurnal variation and is significantly attenuated in the morning. Morning attenuation of endothelial function should be recognized in clinical research and may play an important role in the circadian variation of the occurrence of acute cardiovascular events.
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In humans, vascular endothelial function is relatively impaired in the morning, and therefore potentially implicated in the morning increase in adverse cardiovascular events.
“In humans, vascular endothelial function is relatively impaired in the morning (6, 123-126), and therefore potentially implicated in the morning increase in adverse CV events (127).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [127]
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References 21 · Cited by 124
Research works printed but not linked: 1
- Zeier AM, Drexler H, Wollschlager H, Just H Modulation of cor- onary vasomotor tone in humans. Circulation 1991;83:391-401
- Authors
- Etsuda, H., Takase, B., Kusano, H., Hamabe, A., Kuhara, R., Akima, T., Matsushima, Y., Arakawa, K., Satomura, K., Ohsuzu, F., Kurita, A., & Uehata, A.
- Affiliations
- National Defense Medical College (JP)
- Self-Defense Forces Central Hospital (JP)
- Corresponding author
- Takase, Bonpei
- Venue
- Clinical Cardiology
- Publisher
- Wiley
- Published
- 1999-06
- Volume
- 22
- Issue
- 6
- Pages
- 417-421
- ISSN
- 0160-9289 (ISSN-L)
- 1932-8737
- PMC
- PMC6656222
- OpenAlex
- W1997122358
- Cited by
- 124
- References
- 21
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 7 · 2014: 3 · 2013: 3 · 2012: 3
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Clinical Cardiology (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- flow-mediated dilation, endothelial function, diurnal variation, brachial artery, reactive hyperemia, circadian rhythm, acute cardiovascular events, healthy young men
- MeSH terms
- Adult, Blood Pressure, Brachial Artery, Cardiovascular Diseases, Circadian Rhythm, Endothelium, Vascular, Heart Rate, Humans, Male, Regional Blood Flow, Ultrasonography, Vascular Resistance, Vasodilation
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