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Cited by 246Global Cancer Incidence and ScreeningChildhood Cancer Survivors' Quality of LifeAcute Lymphoblastic Leukemia research

Childhood and adolescent cancer survival in the US by race and ethnicity for the diagnostic period 1975‐1999

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Linabery, Amy M., Ross, Julie A.·2008·Cancer
DOI 10.1002/cncr.23866PMC PMC2765225
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Abstract

BACKGROUND.: Survival trends provide a measure of improvement in detection and treatment over time. In the current study, updated childhood and adolescent cancer survival statistics are presented, overall and among demographic subgroups, including Hispanics, for whom to the authors' knowledge national rates have not been previously reported. These results extend those provided by the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program in their detail and interpretation. METHODS.: Survival trends of primary cancers in children and adolescents (ages birth to 19 years) were evaluated using SEER 9 data. Five‐year and 10‐year relative survival rates across 5‐year (1975‐1979, 1985‐1989, and 1995‐1999) and 10‐year (1975‐1984 and 1985‐1994) cohorts were compared via Z‐tests. Annual percent change (APC) in survival was computed via weighted least‐squares regression. Rates in Hispanic children and adolescents were compared with those in non‐Hispanic whites and blacks (SEER 13, 1995‐1999). RESULTS.: Five‐year survival rates increased significantly overall (1975‐1979: 63% vs 1995‐1999: 79%; P < .0001) and for nearly all histologic types examined; increases were greatest for ependymoma (+37%; P < .0001) and non‐Hodgkin lymphoma (+34%; P < .0001). Hispanic children and adolescents had somewhat poorer 5‐year rates than non‐Hispanic whites overall (74% vs 81%; P < .0001) and for Ewing sarcoma, leukemia, central nervous system tumors, and melanoma. Ten‐year rates also increased significantly overall (1975‐1984: 61% vs 1985‐1994: 72%; P < .0001) and for a majority of cancer types. The largest improvements were noted for acute lymphoblastic leukemia (+19%; P < .0001) and non‐Hodgkin lymphoma (+19%; P < .0001). CONCLUSIONS.: Observed trends reinforce the need for resources devoted to advancing treatment modalities, reducing disparities among racial/ethnic groups and adolescents, and providing long‐term care of survivors. Cancer 2008. © 2008 American Cancer Society.

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  • Recurrent, refractory and metastatic RMS represents one of the persistent clinical therapeutic challenges and unmet clinical need, with improvement in 5-year survival experiencing one of the smallest increases of all pediatric and AYA cancers.

    “of which recurrent, refractory and metastatic RMS represents one of the persistent clinical therapeutic challenges and unmet clinical need,88–90 with improvement in 5-year survival experiencing one of the smallest increases of all pediatric and AYA cancers.91–95”

    From Functional tumor cell-intrinsic STING, not host STING, drives local and systemic antitumor immunity and therapy efficacy following cryoablation (2023) · cites this paper as [91]

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Authors
Linabery, A. M., & Ross, J. A.
Affiliations
University of Minnesota (US)
Corresponding author
Linabery, Amy M.
ORCID
Linabery, Amy M.
Venue
Cancer
Publisher
Wiley
Published
2008-10-17
Volume
113
Issue
9
Pages
2575-2596
ISSN
  • 0008-543X (ISSN-L)
  • 1097-0142
DOI
10.1002/cncr.23866
PMC
PMC2765225
OpenAlex
W2082964850
Cited by
246
References
31
Citations by year
2026: 4 · 2025: 8 · 2024: 10 · 2023: 9 · 2022: 6 · 2021: 12 · 2020: 25 · 2019: 11 · 2018: 9 · 2017: 12 · 2016: 20 · 2015: 13 · 2014: 18 · 2013: 12 · 2012: 19
FWCI
10.22
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (T32CA099936)
Topics
  • Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
Keywords
childhood cancer, adolescent cancer, cancer survival trends, racial and ethnic disparities, Hispanic children, non-Hispanic whites, African Americans, ependymoma, non-Hodgkin lymphoma, acute lymphoblastic leukemia, Ewing sarcoma, central nervous system tumors, melanoma, SEER, relative survival, health disparities, cancer treatment advances
MeSH terms
Adolescent, Adult, Black or African American, Child, Child, Preschool, Ethnicity, Female, Hispanic or Latino, Humans, Infant, Infant, Newborn, Male, Mortality, Neoplasms, Prognosis, Time Factors, United States, Survival Rate, SEER Program, Black People, White People

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