The DOI matches its Crossref record.
Neuroendocrine tumors of midgut and hindgut origin: Tumor‐node‐metastasis classification determines clinical outcome
Open accessAbstract
BACKGROUND: Prognostic classification of neuroendocrine tumor (NET) patients is difficult due to the complexity of current classification systems. A recent proposal for a tumor‐node‐metastasis (TNM) classification and a grading system based on the proliferative fraction proved valid in NETs of foregut origin. The purpose of this study was to test the efficacy of a proposal for TNM staging and grading for midgut and hindgut NETs. METHODS: Two hundred seventy patients with histologically proven midgut and hindgut NETs were investigated. Epidemiological, clinicopathological, and tumor‐specific data at initial diagnosis were recorded. Tumors were classified according to the World Health Organization (WHO) and the recent European Neuroendocrine Tumor Society‐TNM staging and grading proposal. Survival analysis and statistical testing for independent prognostic factors were performed using log‐rank tests and Cox regression. RESULTS: Of 270 NETs originating in the midgut or hindgut, 7% (5‐year survival rate [YSR], 100%) were stage 1, 8% (5‐YSR, 100%) were stage 2, 19% (5‐YSR, 89.5%) were stage 3, and 66% (5‐YSR, 83.3%) were stage 4 NETs; 62% (5‐YSR 95.2%) were grade 1, 32% (5‐YSR 82.0%) were grade 2, and 6% (5‐YSR, 51.4%) were grade 3 NETs. WHO classification significantly separated poorly from well‐differentiated NET or carcinomas but did not further discriminate. TNM staging significantly separated stages 1, 2, and 3 from stage 4 NETs, as did grading according to proliferative capacity for all grades. Multivariate analysis confirmed these results, particularly for Ki67 grading. CONCLUSIONS: The acquired data confirmed the prognostic relevance of the proposed TNM staging and grading system and demonstrated the applicability of these classification tools. The TNM system can therefore facilitate therapeutic stratification and comparison of data from different institutions. Cancer 2011. © 2011 American Cancer Society.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
ENETS Consensus Guidelines Update for Neuroendocrine Neoplasms of the Jejunum and Ileum
Niederle, B., Pape, U.-F., Costa, F., Gross, D., Kelestimur, F., Knigge, U., Öberg, K., Pavel, M., Perren, A., Toumpanakis, C., et al. (2016) · Neuroendocrinology · doi:10.1159/000443170 · Cited by 474
Self-citationClinical syndromes related to gastrointestinal neuroendocrine neoplasms
Boutzios, G., & Kaltsas, G. (2015) · Frontiers of hormone research · doi:10.1159/000382053 · Cited by 50
Neuroendocrine Neoplasms of the Gut
La Rosa, S., Uccella, S., & Rindi, G. (2021) · The Spectrum of Neuroendocrine Neoplasia · doi:10.1007/978-3-030-54391-4_10 · Cited by 5
Self-citation
Metadata
- Authors
- Jann, H., Roll, S., Couvelard, A., Hentic, O., Pavel, M., Müller‐Nordhorn, J., Koch, M., Röcken, C., Rindi, G., Ruszniewski, P., Wiedenmann, B., & Pape, U.
- Venue
- Cancer
- Publisher
- Wiley
- Published
- 2011-01-18
- Volume
- 117
- Issue
- 15
- Pages
- 3332-3341
- ISSN
- 0008-543X (ISSN-L)
- 1097-0142
- OpenAlex
- W2005429053
- Cited by
- 289
- References
- 0
- FWCI
- 16.64
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
