Cited by 250Palliative Care and End-of-Life IssuesPalliative and Oncologic CareStatistical Methods in Clinical Trials

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Attrition rates, reasons, and predictive factors in supportive care and palliative oncology clinical trials

Open access

Hui, David, Glitza, Isabella, Chisholm, Gary, Yennu, Sriram, Bruera, Eduardo·2013·Cancer

Open this paper in CoChat — free account

Abstract

BACKGROUND: Attrition is common among supportive care/palliative oncology clinical trials. However, to the authors' knowledge, few studies to date have documented the reasons and predictors for dropout. In the current study, the authors' objective was to determine the rate, reasons, and factors associated with attrition both before reaching the primary endpoint and at the end of the study. METHODS: A review of all prospective interventional supportive care/palliative oncology trials conducted in the Department of Palliative Care and Rehabilitation Medicine at The University of Texas MD Anderson Cancer Center in Houston between 1999 and 2011 was performed. Patient and study characteristics and attrition data were extracted. RESULTS: A total of 1214 patients were included in 18 clinical trials. The median age of the patients was 60 years. Approximately 41% had an Eastern Cooperative Oncology Group performance status of ≥ 3, a median Edmonton Symptom Assessment Scale (ESAS) for fatigue of 7 of 10, and a median ESAS for dyspnea of 2 of 10. The attrition rate was 26% (95% confidence interval [95% CI], 23%‐28%) for the primary endpoint and 44% (95% CI, 41%‐47%) for the end of the study. Common reasons for primary endpoint dropout were symptom burden (21%), patient preference (15%), hospitalization (10%), and death (6%). Primary endpoint attrition was associated with a higher baseline intensity of fatigue (odds ratio [OR], 1.10 per point; P = .01) and a longer study duration ( P = .04). End‐of‐study attrition was associated with higher baseline levels of dyspnea (OR, 1.06; P = .01), fatigue (OR, 1.08; P = .01), Hispanic race (OR, 1.87; P = .002), higher level of education ( P = .02), longer study duration ( P = .01), and outpatient studies ( P = 0.05). CONCLUSIONS: The attrition rate was high in supportive care/palliative oncology clinical trials, and was associated with various patient characteristics and a high baseline symptom burden. These findings have implications for future clinical trial design including eligibility criteria and sample size calculation. Cancer 2013. © 2012 American Cancer Society.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/cncr.27854

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Distrust, Race, and Research
Corbie-Smith, G. M., Thomas, S. B., & George, D. M. M. S. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.21.2458 · Cited by 1,067
Effectiveness of Specialized Palliative Care
Zimmermann, C., Riechelmann, R. P., Krzyzanowska, M. K., Rodin, G., & Tannock, I. F. (2008) · JAMA · doi:10.1001/jama.299.14.1698 · Cited by 468
Trajectory of Performance Status and Symptom Scores for Patients With Cancer During the Last Six Months of Life
Seow, H. Y., Barbera, L. C., Sutradhar, R., Howell, D., Dudgeon, D. J., Atzema, C. L., Liu, Y., Husain, A. F., SUSSMAN, J. S., & Earle, C. C. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.30.7173 · Cited by 456
Challenges in palliative care research; recruitment, attrition and compliance: experience from a randomized controlled trial
Jordhøy, M. S., Kaasa, S., Fayers, P. M., Underland, G., & Ahlner‐Elmqvist, M. (1999) · Palliative Medicine · doi:10.1191/026921699668963873 · Cited by 312
Patient-Controlled Methylphenidate for Cancer Fatigue: A Double-Blind, Randomized, Placebo-Controlled Trial
Bruera, E. D., Valero, V., Driver, L., Shen, L. F., Willey, J. S., Zhang, T., & Palmer, J. L. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.8506 · Cited by 290
Self-citation
Methodologic issues in effectiveness research on palliative cancer care: a systematic review.
Rinck, G., van den Bos, G. A. M., Kleijnen, J., de Haes, J. C. J. M., Schade, E., & Veenhof, C. H. N. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.4.1697 · Cited by 268
Race, Medical Researcher Distrust, Perceived Harm, and Willingness to Participate in Cardiovascular Prevention Trials
Braunstein, J. B., Sherber, N., Schulman, S. P., Ding, E. L., & Powe, N. R. (2008) · Medicine · doi:10.1097/md.0b013e3181625d78 · Cited by 256
Evaluation of a palliative care service: problems and pitfalls
McWhinney, I. R., Bass, M. J., & Donner, A. P. (1994) · BMJ · doi:10.1136/bmj.309.6965.1340 · Cited by 253
Why are trials in palliative care so difficult?
Grande, G., & Todd, C. J. (2000) · Palliative Medicine · doi:10.1191/026921600677940614 · Cited by 215
Identifying, recruiting, and retaining seriously-ill patients and their caregivers in longitudinal research
Steinhauser, K. E., Clipp, E. C., Hays, J. C., Olsen, M. K., Arnold, R. M., Christakis, N. A., Lindquist, J. H., & Tulsky, J. A. (2006) · Palliative Medicine · doi:10.1177/0269216306073112 · Cited by 210

Flagged first, then by citations

Show all 31 references

Sorted by citations

Items 101–200 of 250

Who accesses complementary therapies and why?: An evaluation of a cancer care service
Matthews, M., Glackin, M., Hughes, C., & Rogers, K. (2014) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2014.09.005 · Cited by 12
Intention-to-Treat Analyses for Randomized Controlled Trials in Hospice/Palliative Care: The Case for Analyses to be of People Exposed to the Intervention
Kochovska, S., Huang, C., Johnson, M. J., Agar, M. R., Fallon, M., Kaasa, S., Hussain, J. A., Portenoy, R. K., Higginson, I. J., & Currow, D. C. (2019) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2019.10.026 · Cited by 12
Implementing a Standardized Care Pathway Integrating Oncology, Palliative Care and Community Care in a Rural Region of Mid-Norway
Brenne, A., Løhre, E. T., Knudsen, A. K., Thronæs, M., Lund, J., Kongshaug, N., Neverdal, M. N., Rystad, K., Johansen, M. H., Braseth, T. I., et al. (2021) · Oncology and Therapy · doi:10.1007/s40487-021-00176-y · Cited by 12
Barriers to research in palliative care in France
Rhondali, W., Berthiller, J., Hui, D., Yennurajalingam, S., Lafumas, V., Ledoux, M., Strasser, F., & Filbet, M. (2013) · BMJ Supportive & Palliative Care · doi:10.1136/bmjspcare-2012-000360 · Cited by 12
Self-citation
Do drugs offering only PFS maintain quality of life sufficiently from a patient’s perspective? Results from AVALPROFS (Assessing the ‘VALue’ to patients of PROgression Free Survival) study
Jenkins, V. A., Farewell, V. T., May, S. F., Catt, S., Matthews, L., Shilling, V. M., Dickson, J., Simcock, R., & Fallowfield, L. J. (2018) · Supportive Care in Cancer · doi:10.1007/s00520-018-4273-3 · Cited by 12
Making the case for completion bonuses in clinical trials
Largent, E. A., & Lynch, H. F. (2018) · Clinical Trials · doi:10.1177/1740774518820503 · Cited by 12
Olanzapine for Anorexia in Patients With Incurable Cancer and Cachexia (OlAnCa): A Double-Blind, Placebo-Controlled, Randomized Clinical Trial.
Othman, N. O., Abdel-Aal, H. H., Elsherief, W. A., Farag, D. E., Hunter, C. N., & Alsirafy, S. A. (2025) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2025.7033 · Cited by 11
African American Recruitment in Early Heart Failure Palliative Care Trials: Outcomes and Comparison With the ENABLE CHF-PC Randomized Trial
Stockdill, M. L., Dionne-Odom, J. N., Wells, R., Ejem, D., Azuero, A., Keebler, K., Sockwell, E., Tims, S., Burgio, K. L., Engler, S., et al. (2023) · Journal of Palliative Care · doi:10.1177/0825859720975978 · Cited by 11
“There was No Opportunity to Express Good or Bad”: Perspectives From Patient Focus Groups on Patient Experience in Clinical Trials
Boyd, P., Sternke, E. A., Tite, D. J., & Morgan, K. H. (2024) · Journal of Patient Experience · doi:10.1177/23743735241237684 · Cited by 11
Patients’ views of routine quality of life assessment following a diagnosis of early-stage non-small cell lung cancer
Pompili, C., Boele, F. W., Absolom, K. L., Holch, P., Clayton, B., Smyllie, E., Franks, K., & Velikova, G. (2020) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1093/icvts/ivaa123 · Cited by 11
Assessment of a Structured Self-Management Support Intervention by Nurses for Patients With Incurable Cancer
de Veer, A. J. E., Slev, V. N., Pasman, H. R. W., Leeuw, I. M. V., Francke, A. L., & van Uden‐Kraan, C. F. (2020) · Oncology nursing forum · doi:10.1188/20.onf.305-317 · Cited by 12
A Pilot Study on the Impact of the BumptUp® Mobile App on Physical Activity during and after Pregnancy
Tinius, R. A., Blankenship, M. M., Colao, A. M., Hawk, G. S., Perera, M., & Schoenberg, N. E. (2022) · Sustainability · doi:10.3390/su141912801 · Cited by 10
Device assessed activity behaviours in patients with indwelling pleural catheter: A sub‐study of the Australasian Malignant PLeural Effusion ( AMPLE )‐2 randomized trial
Peddle‐McIntyre, C. J., Muruganandan, S., McVeigh, J. A., Fitzgerald, D. B., Straker, L. M., Newton, R. U., Murray, K., & Lee, G. (2023) · Respirology · doi:10.1111/resp.14451 · Cited by 10
Cognitive Processing Therapy for the Treatment of PTSD, Depression and Anxiety in Syrian Refugees in Egypt
ElBarazi, A. S., Tikamdas, R., Ahmed, S., & Ramadan, S. (2022) · Intervention · doi:10.4103/intv.intv_33_21 · Cited by 11
Assessment of sensorimotor and strength related function of breast cancer patients during systemic drug therapy: a prospective observational study
Tuğral, A., Arıbaş, Z., Akyol, M., & Bakar, Y. (2023) · BMC Cancer · doi:10.1186/s12885-023-11494-x · Cited by 9
Detecting the Dark Matter of Unpublished Clinical Cancer Studies
Pasalic, D., Fuller, C. D., Mainwaring, W., Lin, T. A., Miller, A. B., Jethanandani, A., Espinoza, A. F., Grossberg, A. J., Jagsi, R., Das, P., et al. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.08.015 · Cited by 9
First-line methadone for cancer pain: titration time analysis
Mammana, G., Bertolino, M., Bruera, E. D., Orellana, F., Vega, F., Peirano, G., Bunge, S., Armesto, A. R., & Dran, G. (2021) · Supportive Care in Cancer · doi:10.1007/s00520-021-06211-y · Cited by 9
Self-citation
Video decision support tool promoting values conversations in advanced care planning in cancer: protocol of a randomised controlled trial
Michael, N. G., O’Callaghan, C. C., Georgousopoulou, E. N., Melia, A., Sulistio, M., & Kissane, D. W. (2021) · BMC Palliative Care · doi:10.1186/s12904-021-00794-3 · Cited by 9
Zopiclone versus placebo for short-term treatment of insomnia in patients with advanced cancer—a double-blind, randomized placebo-controlled clinical multicenter phase IV trial
Jakobsen, G., Sjue, K., Paulsen, Ø., Kaasa, S., Hjermstad, M. J., & Klepstad, P. (2022) · Supportive Care in Cancer · doi:10.1007/s00520-022-07537-x · Cited by 10
Oral Nutritional Support Can Shorten the Duration of Parenteral Hydration in End-of-Life Cancer Patients: A Randomized Controlled Trial
Ishiki, H., Iwase, S., Gyoda, Y., Kanai, Y., Ariyoshi, K., Miyaji, T., Tahara, Y., Kawaguchi, T., Chinzei, M., & Yamaguchi, T. (2014) · Nutrition and Cancer · doi:10.1080/01635581.2015.976312 · Cited by 9
Cancer care treatment attrition in adults: Measurement approaches and inequities in patient dropout rates – a rapid review
Shand, J., Stovold, E. M., Goulding, L., & Cheema, K. (2024) · BMC Cancer · doi:10.1186/s12885-024-13096-7 · Cited by 8
End-of-life and hospice care for neurologic illness
Daly, F. N., & Ramanathan, U. (2022) · Handbook of clinical neurology · doi:10.1016/b978-0-323-85029-2.00006-3 · Cited by 8
Feasibility study of a mobile application (ACT-ON) to complement acceptance and commitment therapy (ACT) intervention in cancer patients
García-Torres, F., García-Carmona, M., Rubio, S., Luque, B., Gómez-Solís, Á., & Aranda, E. (2023) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2023.105131 · Cited by 5
Epidemiology of Pain Among Patients with Solid Metastatic Cancer During the Last Year of Life
Chaudhry, I., Shafiq, M., Teo, I., Özdemir, S., & Malhotra, C. (2022) · Journal of Pain Research · doi:10.2147/jpr.s375874 · Cited by 7
“It Can Be Hard But It's Not Bad”: Three Questions to Solicit Caregiver Perceptions of Benefits and Burdens to Participating in Pediatric Palliative Care Research
Reggio, C., Mowbray, C., Waldron, M. K., Rood, A. L., Sibilia, G., Mooney‐Doyle, K., & Hinds, P. S. (2021) · Journal of Palliative Medicine · doi:10.1089/jpm.2020.0618 · Cited by 7
Feasibility, pitfalls and results of a structured concept-development phase for a randomized controlled phase III trial on radiotherapy in primary prostate cancer patients
Spohn, S. K. B., Adebahr, S., Huber, M., Jenkner, C., Wiehle, R., Nagavci, B., Schmucker, C. M., Carl, E., Chen, R. C., Weber, W., et al. (2022) · BMC Cancer · doi:10.1186/s12885-022-09434-2 · Cited by 7
Prospective case series of neuropathic cancer pain in patients treated with an EGFR-inhibitor
Cameron, M. G., & Kersten, C. (2022) · Palliative Medicine · doi:10.1177/02692163221102003 · Cited by 7
Exercise interventions for advanced cancer palliative care patients: A systematic literature review and descriptive evidence synthesis of randomized controlled trials
Rogers-Shepp, I., Bhattacharya, S., Mennillo, H., Kumar, R. P., Hsieh, B., & Anandarajah, G. (2023) · Palliative Medicine · doi:10.1177/02692163231162888 · Cited by 7
Bringing a humanistic approach to cancer clinical trials
Arai, R. J., Longo, E. S., Sponton, M. H. D. C., & Estevez-Diz, M. D. P. (2017) · ecancermedicalscience · doi:10.3332/ecancer.2017.738 · Cited by 7
Development of the IRIS-AR strategy: an intervention to improve rates of accrual and retention for the VTE-PRO randomized controlled trial
Fahim, C., Hylton, D. A., Simunovic, M. R. I., Agzarian, J., Finley, C., Hanna, W. C., & Shargall, Y. (2019) · Trials · doi:10.1186/s13063-019-3536-8 · Cited by 8
Predictors of Intervention Session Completion in a Randomized Clinical Trial of a Behavioral Cancer Pain Intervention
Winger, J. G., Nuñez, C., Kelleher, S. A., Ingle, K., Gandhi, V., Keefe, F. J., & Somers, T. J. (2020) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2020.01.020 · Cited by 7
Interim Analysis of Attrition Rates in Palliative Care Study on Dignity Therapy
Samuels, V., Schoppee, T. M., Greenlee, A., Gordon, D., Jean, S., Smith, V. M., Reed, T., Kittelson, S. M., Quest, T. E., O’Mahony, S., et al. (2021) · American Journal of Hospice and Palliative Medicine® · doi:10.1177/1049909121994309 · Cited by 7
Failed implementation of a nursing intervention to support family caregivers: An evaluation study using Normalization Process Theory
Becqué, Y. N., Rietjens, J. A. C., van der Heide, A., & Witkamp, E. (2024) · Journal of Advanced Nursing · doi:10.1111/jan.16261 · Cited by 7
Effect of paracentesis on the survival of patients with terminal cancer and ascites: a propensity score–weighted analysis of the East Asian Collaborative Cross-cultural Study to Elucidate the Dying Process
Masuda, K., Ishiki, H., Yokomichi, N., Yamaguchi, T., Ito, T., Takatsu, H., Amano, K., Hiramoto, S., Yamauchi, T., Kawaguchi, T., et al. (2022) · Supportive Care in Cancer · doi:10.1007/s00520-022-07057-8 · Cited by 6
Humour interventions for patients in palliative care—a randomized controlled trial
Linge-Dahl, L., Kreuz, R., Stoffelen, M., Heintz, S., Ruch, W., von Hirschhausen, E., & Radbruch, L. (2023) · Supportive Care in Cancer · doi:10.1007/s00520-023-07606-9 · Cited by 6
Non-pharmacological interventions in primary care to improve the quality of life of older patients with palliative care needs: a systematic review of randomised controlled trials
Cardoso, C. S., Matos, J. R., Prazeres, F., & Gomes, B. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-073950 · Cited by 6
Feasibility and effectiveness of a two-tiered intervention involving training and a new consultation model for patients with palliative care needs in primary care: A before-after study
Cardoso, C. S., Prazeres, F., Oliveiros, B., Nunes, C., Simões, P. A., Aires, C., Rita, P., Penetra, J., Lopes, P., Alcobia, S., et al. (2024) · Palliative Medicine · doi:10.1177/02692163231219682 · Cited by 6
Quality of Life and Associated Factors among Cancer Patients Receiving Chemotherapy during the COVID-19 Pandemic in Thailand
Witwaranukool, P., Seedadard, R., Krongthaeo, S., & Leaungsomnapa, Y. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21030317 · Cited by 6
An Analysis of Incentive Schemes for Participant Retention in Clinical Studies
Song, X., Mehrotra, M., & Rajapakshe, T. (2021) · Manufacturing & Service Operations Management · doi:10.1287/msom.2022.1184 · Cited by 6
The role of corticosteroids in the palliation of dyspnea in cancer patients: an evidence-based review
Hui, D., & Yennurajalingam, S. (2023) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000677 · Cited by 6
Self-citation
The effectiveness of a nurse‐led intervention to support family caregivers in end‐of‐life care: Study protocol for a cluster randomized controlled trial
Becqué, Y. N., Rietjens, J. A. C., van der Heide, A., & Witkamp, E. (2020) · Journal of Advanced Nursing · doi:10.1111/jan.14326 · Cited by 6
What influenced people with chronic or refractory breathlessness and advanced disease to take part and remain in a drug trial? A qualitative study
Lovell, N., Etkind, S. N., Bajwah, S., Maddocks, M. M., & Higginson, I. J. (2020) · Trials · doi:10.1186/s13063-020-4129-2 · Cited by 6
Exploration of motivation to participate in a study of cancer-related cognitive impairment among patients with newly diagnosed aggressive lymphoma: a qualitative sub-study
Gates, P., Dhillon, H. M., Gough, K., Wilson, C. J., Hawkes, E. A., Scudder, L., Cushion, T., & Krishnasamy, M. (2021) · Supportive Care in Cancer · doi:10.1007/s00520-021-06527-9 · Cited by 5
Establishing a Longitudinal Opioid Pharmacogenomic Registry for Cancer Patients: Feasibility and Acceptability
Philip, J. A. M., Wong, A. K. Y., Pasanen, L., Somogyi, A. A., Rubio, J. P., Klepstad, P., Collins, A., Gibbs, P., & Le, B. H. C. (2022) · Journal of Palliative Medicine · doi:10.1089/jpm.2022.0385 · Cited by 6
Feasibility of Music and Hypnotic Suggestion to Manage Chronic Pain
Johnson, A. J., Kekecs, Z., Roberts, R. L., Gavin, R. B., Brown, K. S., & Elkins, G. R. (2017) · International Journal of Clinical and Experimental Hypnosis · doi:10.1080/00207144.2017.1348858 · Cited by 7
The Effect of Self-efficacy–Enhancing Interventions on Quality of Life of Cancer Survivors
Yan, K., Lengacher, C. A., Dandamrongrak, C., Wang, H., Hanson, A. R. M., & Beckie, T. M. (2024) · Cancer Nursing · doi:10.1097/ncc.0000000000001372 · Cited by 5
Participant and trial characteristics reported in predictive analyses of trial attrition: an umbrella review of systematic reviews of randomised controlled trials across multiple conditions
McChrystal, R., Lees, J. S., Gillies, K., McAllister, D., & Hanlon, P. (2025) · Trials · doi:10.1186/s13063-025-08794-x · Cited by 5
Barriers and facilitators for participation in brain magnetic resonance imaging (MRI) scans in cancer research: a feasibility and acceptability analysis
Manuweera, T., Karunakaran, K. D., Baechler, C., Rosales, J., Kleckner, A. S., Rosenblatt, P., Ciner, A., & Kleckner, I. R. (2025) · Supportive Care in Cancer · doi:10.1007/s00520-025-09549-9 · Cited by 5
Enhancing accessibility and impact of digitally enabled clinical trials: the WeShare engagement and equity toolkit
Franzoi, M. A., Everhard, S., Gillanders, E., & Vaz-Luis, I. (2025) · ESMO Real World Data and Digital Oncology · doi:10.1016/j.esmorw.2025.100175 · Cited by 5
Best practices for recruitment in veterinary clinical trials
Quigley, M., McKenna, C., & Webb, T. L. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1418747 · Cited by 10
Comparability of the Australian National Cancer Symptom Trials (CST) Group's Study Populations to National Referrals to Non-CST Specialist Palliative Care Services Participating in the Palliative Care Outcomes Collaboration
Matsuoka, H., Allingham, S. F., Fazekas, B. S., Brown, L., Vandersman, Z., Clark, K., Agar, M. R., & Currow, D. C. (2018) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2018.09.017 · Cited by 5
A Group Intervention Combining Self-Hypnosis and Self-Care in Oncology: Implementation in Daily Life and Perceived Usefulness
Grégoire, C., Faymonville, M.-É., Vanhaudenhuyse, A., Jérusalem, G., Monseur, J. J., & Bragard, I. (2023) · International Journal of Clinical and Experimental Hypnosis · doi:10.1080/00207144.2023.2249044 · Cited by 7
Correlates related to follow‐up in a community engagement program in North Central Florida
Otufowora, A., Liu, Y., Varma, D. S., Striley, C. W., & Cottler, L. B. (2020) · Journal of Community Psychology · doi:10.1002/jcop.22450 · Cited by 6
A phase 2 quasi-experimental trial evaluating the feasibility, acceptability, and potential effectiveness of complex nursing intervention focused on QoL assessment on advanced cancer patients with palliative care needs: study protocol
Catania, G., Bagnasco, A., Signori, A., Pilastri, P., Bottino, M., Cervetti, C., Zanini, M. P., Aleo, G., & Sasso, L. (2017) · Pilot and Feasibility Studies · doi:10.1186/s40814-017-0196-x · Cited by 5
Feasibility of a Health Coach Intervention to Reduce Sitting Time and Improve Physical Functioning Among Breast Cancer Survivors: Pilot Intervention Study
Tam, R. M., Zablocki, R., Liu, C., Narayan, H. K., Natarajan, L., LaCroix, A. Z., Dillon, L. W., Sakoulas, E. M., & Hartman, S. J. (2023) · JMIR Cancer · doi:10.2196/49934 · Cited by 4
Defining the trials nurses’ role in operationalising a medicinal cannabis clinical trial
Razmovski‐Naumovski, V., West, P. A., Bellemore, F. A., Byfieldt, N., Bellamy, D., Chye, R., Clark, K., Martin, J. H., Fazekas, B. S., Phillips, J. L., et al. (2021) · Collegian Journal of the Royal College of Nursing Australia · doi:10.1016/j.colegn.2021.10.003 · Cited by 4
The effectiveness of COPA-based training program on the infection-control competencies of newly hired healthcare professionals
Ta’an, W., Al‐Hammouri, M. M., Al‐Faouri, I., & Suliman, M. (2022) · Teaching and learning in nursing · doi:10.1016/j.teln.2022.06.009 · Cited by 4
Regret in Clinical Trial Participation Among Cancer Patients
Baker, K. M., Andersen, L., McHugh, M., Foxwell, A. M., Zhou, Q., Ratcliffe, S. J., Huang, L., Aryal, S., Grady, C., & Ulrich, C. M. (2024) · Journal of Palliative Medicine · doi:10.1089/jpm.2024.0147 · Cited by 4
Incidence and management of diarrhoea associated with abemaciclib and endocrine therapy for hormone-receptor positive, HER2-negative metastatic breast cancer: the UK patients’ experiences
Harder, H., Starkings, R., Fallowfield, L. J., May, S. F., & Shilling, V. M. (2025) · Supportive Care in Cancer · doi:10.1007/s00520-025-09440-7 · Cited by 4
Experiences of cancer rehabilitation among patients in rural areas in northern Iceland: physical and psychosocial well-being, coping, quality of life, and satisfaction with care. A qualitative study
Björnsdóttir, E. B., Hjörleifsdóttir, E., Sigurðardóttir, Þ., Baruchello, G., & Thormodsson, F. R. (2021) · International Journal of Circumpolar Health · doi:10.1080/22423982.2021.1936974 · Cited by 4
Depressive symptoms in the last days of life of patients with cancer: a nationwide retrospective mortality study
Janberidze, E., Pereira, S. M., Hjermstad, M. J., Knudsen, A. K., Kaasa, S., van der Heide, A., & Onwuteaka-Philipsen, B. D. (2015) · BMJ Supportive & Palliative Care · doi:10.1136/bmjspcare-2014-000722 · Cited by 4
Impact of counselling on quality of life and sleep in cancer patients
Matthews, M., Glackin, M., Hughes, C., & Rogers, K. (2014) · British Journal of Nursing · doi:10.12968/bjon.2014.23.sup10.s11 · Cited by 4
Modeling Clinical Trial Attrition Using Machine Intelligence: A driver analytics case study using 1,325 trials representing one million patientsPreprint
Hutchison, E. R., Zhang, Y., Nampally, S., Neelufer, I. K. A., Malkov, V., Weatherall, J., Khan, F., & Shameer, K. (2021) · medRxiv · doi:10.1101/2021.11.12.21266277 · Cited by 4
Implementation of the e-IPOS in Home Palliative Cancer Care: A Quasiexperimental Pilot Study
Consolo, L., Rusconi, D., Colombo, S., Basile, I., Campa, T., Pezzera, D., Benenati, S., Caraceni, A. T., & Lusignani, M. (2024) · American Journal of Hospice and Palliative Medicine® · doi:10.1177/10499091241240667 · Cited by 3
Culturally Sensitive Advance Care Planning for African American Advanced Cancer Patients: A Pilot Randomized Controlled Trial
Knox-Rice, T., & Rhodes, R. L. (2024) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2024.04.014 · Cited by 3
Joint modeling of longitudinal and time-to-event data with missing time-varying covariates in targeted therapy of oncology
Bhattacharjee, A., Vishwakarma, G. K., & Banerjee, S. (2020) · Communications in Statistics Case Studies Data Analysis and Applications · doi:10.1080/23737484.2020.1782286 · Cited by 3
Feasibility and Value of Salivary Cortisol Sampling to Reflect Distress in Head and Neck Cancer Patients Undergoing Chemoradiation: A Proof-of-Concept Study
Chhabria, K., Mark, B., Joshua, A., & Carnaby, G. (2022) · International Journal of Oncology Research · doi:10.23937/2643-4563/1710043 · Cited by 3
An Electronically Delivered Person-Centered Narrative Intervention for Persons Receiving Palliative Care: Protocol for a Mixed Methods Study
Coats, H., Shive, N., Adrian, B., Boyd, A. D., Doorenbos, A. Z., & Schmiege, S. J. (2023) · JMIR Research Protocols · doi:10.2196/41787 · Cited by 3
Cognitive Processing Therapy for the Treatment of PTSD, Depression, Anxiety Symptoms and Difficulties in Emotion Regulation in Syrian Refugee Women Exposed to Intimate Partner Violence
ElBarazi, A. S. (2023) · Intervention · doi:10.4103/intv.intv_7_23 · Cited by 4
Challenges of recruiting hospice inpatients with advanced cancer to research: Reflections on a delirium screening study
Rainsford, S., Bullen, T., & Rosenberg, J. P. (2014) · Progress in Palliative Care · doi:10.1179/1743291x14y.0000000089 · Cited by 3
An investigation into the incidence of pain flare in patients undergoing radiotherapy for symptomatic bone metastases
Goldfinch, R., & White, N. (2018) · Radiography · doi:10.1016/j.radi.2018.01.010 · Cited by 3
Safety and Feasibility of Outpatient Rehabilitation in Patients With Secondary Bone Cancer: A Preliminary Study
TABACOF, L. R., Delgado, A. D., Dewil, S., Reis, F., Velar, C. M., Corteline, M. É. D., Cecatto, R. B., Putrino, D. F., Imamura, M., Battistella, L. R., et al. (2020) · Rehabilitation Oncology · doi:10.1097/01.reo.0000000000000241 · Cited by 3
How to improve participant compliance and retention in clinical trials：A Scoping ReviewPreprint
Yu, M., Lin, Z., Liang, C., Li, C., Zhang, Z., Liu, K., Li, X., Liu, J., & Fei, Y. (2020) · Research Square · doi:10.21203/rs.3.rs-52627/v2 · Cited by 3
Benefits, Harms, and Stakeholder Perspectives Regarding Opioid Therapy for Pain in Individuals With Metastatic Cancer: Protocol for a Descriptive Cohort Study
Jones, K., White, G. E., Bennett, A. V., Bulls, H., Escott, P., Orris, S., Escott, E., Fischer, S. M., Hamm, M. E., Krishnamurti, T., et al. (2023) · JMIR Research Protocols · doi:10.2196/54953 · Cited by 4
Do Complications After Pancreatoduodenectomy Have an Impact on Long-Term Quality of Life and Functional Outcomes?
Gikandi, A., Fong, Z. V., Qadan, M., Narayan, R. R., Lwin, T. M., Castillo, C. F. F.-D., Lillemoe, K. D., & Ferrone, C. R. (2024) · Annals of Surgery Open · doi:10.1097/as9.0000000000000400 · Cited by 2
Light in the darkness – accessibility to palliative care for cancer patients of Chinese background and their families
Lim, C. E. D., Sanchez, C., & Chen, H. (2024) · Journal of Primary Health Care · doi:10.1071/hc24112 · Cited by 2
Behavioral pattern analysis for adherence in clinical trials using sequence mining
Zambrano, E. P., Laguardia, J., DeAntonio, R., & Ledezma, A. (2026) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2026.111607 · Cited by 2
Efficacy of a structured rehabilitation program for patients with terminal cancer: A multicenter randomized controlled trial
Nishiyama, N., Matsuda, Y., Fujiwara, N., Narita, K., Oyamada, S., Ariyoshi, K., Hosono, Y., Kushi, K., 勝昭, 市., Yabuki, R., et al. (2026) · Cancer · doi:10.1002/cncr.70485 · Cited by 2
Families’ healthcare experiences for children with inherited metabolic diseases: protocol for a mixed methods cohort study
Chow, A., Iverson, R., Lamoureux, M., Tingley, K., Jordán, I., Pallone, N., Smith, M. P., Al‐Baldawi, Z., Chakraborty, P. K., Brehaut, J., et al. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-055664 · Cited by 2
Methodological factors regarding patient-reported outcome information for value assessment in palliative care
Fischer, C., Masel, E. K., & Simon, J. (2023) · Annals of Palliative Medicine · doi:10.21037/apm-23-364 · Cited by 2
Head and neck cancer patients with geriatric deficits are more often non-responders and lost from follow-up in quality of life studies
de Vries, J., Vermue, D. J., Sidorenkov, G. A., Festen, S., Langendijk, J. A., de Bock, G. H., & Halmos, G. B. (2024) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-024-08528-w · Cited by 2
Factor Structure and Longitudinal Invariance of the Cancer Behaviour Inventory: Assessing Cancer‐Coping Self‐Efficacy in Patients With Moderate‐to‐High Symptoms
Yan, K., Wang, H., Small, B. J., Elliott, A., Marshall, V. K., Tometich, D. B., & Beckie, T. M. (2025) · Journal of Advanced Nursing · doi:10.1111/jan.16939 · Cited by 2
Effectiveness of Relaxation and Hypnosis Interventions in Distressed Patients With Chronic Diabetic Foot Ulcers: A Longitudinal Pilot Randomised Controlled Trial
Pereira, M. G., Vilaça, M., Pedras, S., Carvalho, A., Vedhara, K., Dantas, M. J., Lopes, A., & Faria, S. (2025) · Stress and Health · doi:10.1002/smi.70029 · Cited by 3
Predictors of adherence, contamination and dropout in home‐based walking by lung and oesophageal cancer patients from two randomised control trials: An exploratory study
Chen, H., Lee, M., Wu, Y., Huang, C., Hsu, P., Chien, L., Tian, J., & Duong, T. L. (2022) · European Journal of Cancer Care · doi:10.1111/ecc.13635 · Cited by 2
Quality versus risk of bias assessment of palliative care trials: comparison of two tools
Isenberg, S. R., Kavalieratos, D., Chow, R., Le, L. W., Wegier, P., & Zimmermann, C. (2020) · BMJ Supportive & Palliative Care · doi:10.1136/bmjspcare-2020-002539 · Cited by 2
The effect of social care nurses on health related quality of life in patients with advanced cancer: A non-randomized, multicenter, controlled trial
Schindel, D., Frick, J., Gebert, P., Grittner, U., Letsch, A., & Schenk, L. (2024) · Quality of Life Research · doi:10.1007/s11136-024-03780-3 · Cited by 2
AVANZACT: protocolo e intervención psicoterapéutica en cáncer avanzado basados en Terapia de Aceptación y Compromiso.
Placer García, L. D., Torrijos Zarcero, M., Rocamora González, C., Muñoz San José, A., & Palao Tarrero, Á. I. (2025) · Psicooncologia · doi:10.5209/psic.102233 · Cited by 1
Living lab modelling as a pilot study assessing the potential psychological health benefits of forest environment for cancer survivors
Kim, M. K., Park, H. J., & Lee, K. J. (2024) · Obstetrics & Gynecology Science · doi:10.5468/ogs.24035 · Cited by 1
Efficacy of a brief mindfulness-based intervention for brain tumor survivors experiencing depressive symptoms: a pilot study
Diplock, B. D., Ellis, J., Perry, J., Sahgal, A., Soliman, H., Moroney, C., Bilodeau, D., & Selchen, S. (2024) · Cancer Survivorship Research & Care · doi:10.1080/28352610.2024.2407120 · Cited by 1
Feasibility, Acceptability, and Potential Effects of a Digital Oral Anticancer Agent Intervention: Protocol for a Pilot Randomized Controlled Trial
Ahmed, S., Maheu, C., Gotlieb, W. H., Batist, G., & Loiselle, C. G. (2025) · JMIR Research Protocols · doi:10.2196/55475 · Cited by 1
Virtual reality for outpatient management of cancer pain: a pilot dosing study
Groninger, H., Violanti, D., McPherson, M. L., Hopkins, K., Carr, A. L., Hurtado, M., & Mete, M. (2025) · Supportive Care in Cancer · doi:10.1007/s00520-025-09723-z · Cited by 1
Considerations in Selecting, Collecting, and Interpreting Outcome Measures for Symptom Science in Oncology
Mitchell, S. A. (2025) · Seminars in Oncology Nursing · doi:10.1016/j.soncn.2025.151948 · Cited by 1
Modeling rates of trial attrition: an analysis of individual participant data from 90 randomized controlled trials of pharmacological interventions for multiple conditions
McChrystal, R., Hanlon, P., Lees, J. S., Phillippo, D., Welton, N. J., Gillies, K., & McAllister, D. (2025) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2025.111971 · Cited by 1
Impact of parenteral nutrition on oral intake and eating pleasure in advanced cancer patients: A sub-analysis of a multicenter randomized controlled trial
Bouleuc, C., Garabige, V., Grodard, G., Anota, A., Aubry, R., & Marchal, T. (2026) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2025.102905 · Cited by 1
Physical and psychosocial benefits of an interdisciplinary end-of-life care model for older adults in residential care homes in Hong Kong
Chan, A. T., Wong, A., Chun, G. K. M., Lou, V. W. Q., & Chow, A. Y. M. (2026) · International Psychogeriatrics · doi:10.1016/j.inpsyc.2025.100176 · Cited by 1
Interventions for Managing Delirium Symptoms in Terminally Ill Patients with Cancer: A Scoping Review
Takeuchi, M., Miyoshi, T., Kako, J., Matsuda, Y., Inoue, S., Tanimukai, H., Wada, S., & Hasegawa, T. (2026) · Journal of Palliative Medicine · doi:10.1177/10966218261418481 · Cited by 1
Conducting clinical trials in supportive and palliative oncology: challenges and opportunities
Hui, D., & Bruera, E. (2026) · Current Opinion in Oncology · doi:10.1097/cco.0000000000001216 · Cited by 1
Self-citation
Cognitive dysfunction associated with cellular immunotherapy for cancer
Hauswirth, A. G., Parsons, M. W., & Dietrich, J. (2026) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdag021 · Cited by 1
Neurological complications of current and emerging CAR-T cell therapies
Hauswirth, A. G., & Dietrich, J. (2026) · Neurotherapeutics · doi:10.1016/j.neurot.2026.e00951 · Cited by 1
The short-term impact of methylprednisolone on patient-reported sleep in patients with advanced cancer in a randomized, placebo-controlled, double-blind trial
Jakobsen, G., Engstrøm, M., Hjermstad, M. J., Rosland, J. H., Aass, N., Albert, E. H., Kaasa, S., Fayers, P. M., Klepstad, P., & Paulsen, Ø. (2020) · Supportive Care in Cancer · doi:10.1007/s00520-020-05693-6 · Cited by 1

Authors: Hui, D., Glitza, I., Chisholm, G., Yennu, S., & Bruera, E.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
Corresponding author: Hui, David
ORCID: Hui, David
Chisholm, Gary
Bruera, Eduardo
Venue: Cancer
Publisher: Wiley
Published: 2012-11-06
Volume: 119
Issue: 5
Pages: 1098-1105
ISSN: 0008-543X (ISSN-L)
1097-0142
DOI: 10.1002/cncr.27854
PMC: PMC3568443
OpenAlex: W2052953863
Cited by: 250
References: 31
Citations by year: 2026: 28 · 2025: 19 · 2024: 22 · 2023: 23 · 2022: 22 · 2021: 35 · 2020: 29 · 2019: 17 · 2018: 11 · 2017: 14 · 2016: 8 · 2015: 7 · 2014: 10 · 2013: 3 · 2012: 1
FWCI: 6.48
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Cancer (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5r01ca124481-03, 5r01nr010162-04)
National Cancer Institute (R01CA12 4481-01, CA 016672, T32CA009666, R01CA122292, R01 CA124481, P30CA016672)
National Institute of Nursing Research (R01NR010162-01A1, R01 NR010162)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative and Oncologic Care
Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
Keywords: attrition, trial dropout, palliative oncology, predictive factors, fatigue, dyspnea, symptom burden, patient preferences, study duration, Hispanic patients, clinical trial design, sample size determination
MeSH terms: Adult, Aged, Aged, 80 and over, Clinical Trials as Topic, Dyspnea, Fatigue, Female, Hospitalization, Humans, Male, Middle Aged, Neoplasms, Palliative Care, Patient Dropouts, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Attrition rates, reasons, and predictive factors in supportive care and palliative oncology clinical trials

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks