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Cited by 3,592Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats

Altman, Joseph, Das, Gopal D.·1965·Journal of Comparative Neurology
DOI 10.1002/cne.901240303
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Abstract

In the autoradiograms of young rats injected with thymidine‐H 3 many of the granule cells of the dentate gyrus were found labeled. The number of labeled cells declined rapidly with increased age at the time of injection. Histological studies showed the presence in young rats of a large germinal matrix of mitotic cells in the ependymal and subependymal layers of the third and lateral ventricles. The areal extent and cell population of this germinal pool declined rapidly from birth on, with a transient rise with a peak at about 15 days. During this latter period the number of “undifferentiated” cells near the granular layer of the dentate gyrus showed a rapid rise with a subsequent decline. The decline in the number of “undifferentiated” cells was accompanied by a rise in the number of differentiated granule cells. Cell counts in homologous parts of the dentate gyrus indicated a six‐fold increase in the number of differentiated granule cells from birth to three months. We postulated that undifferentiated cells migrate postnatally from the forebrain ventricles to the hippocampus where they become differentiated. The possible functional significance of delayed hippocampal neurogenesis is discussed with reference to our finding of incorporation of testosterone‐H 3 by cells of the hippocampus, implicating that they may function as receptors of gonadal hormones.

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Crossref · 10.1002/cne.901240303

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Research works printed but not linked: 2

  1. Allen E., 1912, The cessation of mitosis in the central nervous system of the albino rat, J. Comp. Neur., 22, 547
  2. Kjellgren K., 1944, Studien über die Entwicklung der Neuronen nach der Geburt, ihre Regeneration und die Asymmetrien ihrer Verteilung beim Menschen, Acta Psychiat. Neurol. Scand., Suppl., 29, 1

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Metadata

Authors
Altman, J., & Das, G. D.
Affiliations
Massachusetts Institute of Technology (US)
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1965-06
Volume
124
Issue
3
Pages
319-335
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.901240303
OpenAlex
W1980499453
Cited by
3,592
References
18
Citations by year
2026: 55 · 2025: 79 · 2024: 66 · 2023: 92 · 2022: 112 · 2021: 131 · 2020: 130 · 2019: 136 · 2018: 116 · 2017: 128 · 2016: 132 · 2015: 143 · 2014: 142 · 2013: 145 · 2012: 160
FWCI
6.21
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 14374 d)
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
dentate gyrus granule cells, germinal matrix, ependymal layer, undifferentiated cells, cell migration, rat brain development
MeSH terms
Animals, Animals, Newborn, Autoradiography, Cell Differentiation, Hippocampus, Testosterone, Thymidine, Tritium, Rats, In Vitro Techniques

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