The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Adrenal steroids regulate postnatal development of the rat dentate gyrus: I. Effects of glucocorticoids on cell death
Abstract
The rat dentate gyrus undergoes a period of naturally occurring cell death during the first postnatal week. In the adult rat, removal of circulating adrenal steroids by adrenalectomy is followed by massive death in the granule cell layer, thus raising the possibility that developmental cell death results from low levels of these hormones. Interestingly, the first two postnatal weeks of life in the rat, termed the stress hyporesponsive period, are characterized by very low levels of adrenal steroids. In order to determine whether low levels of adrenal steroids enable developmental cell death to occur in the dentate gyrus, we examined the density of pyknotic and healthy cells in the dentate gyrus of rat pups which received one of the following treatments: (1) injections of the endogenous rat glucocorticoid corticosterone during the first postnatal week, or (2) adrenalectomy at the time when glucocorticoid levels normally rise. Quantitative analysis of the density of pyknotic cells in the granule cell layers revealed significant decreases with corticosterone treatment by the end of the first postnatal week. In these same brains, treatment with corticosterone resulted in a substantial increase in the density of pyknotic cells in the hilus. Adrenalectomy resulted in a significant increase in the density of pyknotic cells in the granule cell layer as well as in the hilus. Despite the dramatic alterations in the density of pyknotic cells with both increases and decreases in glucocorticoid levels, the density of healthy cells remained the same. These observations suggest that glucocorticoids regulate several processes, possibly including neurogenesis and migration, in addition to cell death.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In the present study, there was no evidence from TUNEL staining that IL-1β and/or acute stress elicit hippocampal cell death either in vitro or in vivo, which is consistent with previous studies (40–42), although there is one report that severe acute stress increases apoptosis (43).”
From IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress (2008) · cites this paper as [41]
In the citing paper
“Although increased hypothalamic volume supports the notion that HPA axis hyperactivity is associated with susceptibility to chronic stress, increased hippocampal volume may appear contrary to previous studies, which have shown smaller hippocampi in depressed patients (48,49) and hippocampal atrophy following stress (8,31,50–52).”
From Neuroanatomic differences associated with stress susceptibility and resilience (2016) · cites this paper as [51]
Citations
Cites
Regressive Events in Neurogenesis
Cowan, W. M., Fawcett, J. W., O'Leary, D. D. M., & Stanfield, B. B. (1984) · Science · doi:10.1126/science.6474175 · Cited by 1,316
Sapolsky, R. M., & Meaney, M. J. (1986) · Brain Research Reviews · doi:10.1016/0165-0173(86)90010-x · Cited by 999
Bayer, S. A. (1980) · The Journal of Comparative Neurology · doi:10.1002/cne.901900107 · Cited by 913
Schlessinger, A. R., Cowan, W. M., & Gottlieb, D. I. (1975) · The Journal of Comparative Neurology · doi:10.1002/cne.901590202 · Cited by 731
Selective Loss of Hippocampal Granule Cells in the Mature Rat Brain After Adrenalectomy
Sloviter, R. S., Valiquette, G., Abrams, G., Ronk, E. C., Sollas, A. L., Paul, L. A., & Neubort, S. (1989) · Science · doi:10.1126/science.2911756 · Cited by 522
Neurotransmitters in the regulation of neuronal cytoarchitecture
Mattson, M. P. (1988) · Brain Research Reviews · doi:10.1016/0165-0173(88)90020-3 · Cited by 518
A quantitative electron microscopic study of synaptogenesis in the dentate gyrus of the rat
Crain, B. J., Cotman, C. W., Taylor, D. A., & LYNCH, G. S. (1973) · Brain Research · doi:10.1016/0006-8993(73)90088-7 · Cited by 349
Gould, E. A., Woolley, C. S., & McEwen, B. S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90407-u · Cited by 334
Self-citationNaturally Occurring Neuron Death and Its Regulation by Developing Neural Pathways
Cunningham, T. J. (1982) · International review of cytology · doi:10.1016/s0074-7696(08)61172-9 · Cited by 305
Errington, M. L., Lynch, M. A., & Bliss, T. V. P. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90019-4 · Cited by 274
Cited by
Sorted by citations
Adult neurogenesis: from precursors to network and physiology
Abrous, D. N., Koehl, M., & Le Moal, M. (2005) · Physiological Reviews · doi:10.1152/physrev.00055.2003 · Cited by 971
IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress
Koo, J. W., & Duman, R. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708092105 · Cited by 862
Prenatal glucocorticoids and long-term programming
Seckl (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.151u049 · Cited by 825
Stress and hippocampal neurogenesis
Gould, E., & Tanapat, P. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00247-4 · Cited by 818
Self-citationLong-term behavioral and neuroendocrine adaptations to adverse early experience
Ladd, C. O., Huot, R. L., Thrivikraman, K. V., Nemeroff, C. B., Meaney, M. J., & Plotsky, P. M. (2000) · Progress in brain research · doi:10.1016/s0079-6123(08)62132-9 · Cited by 726
Metadata
- Authors
- Gould, E., Woolley, C. S., & McEwen, B. S.
- Affiliations
- Rockefeller University (US)
- Corresponding author
- Gould, Elizabeth
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 1991-11-15
- Volume
- 313
- Issue
- 3
- Pages
- 479-485
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W2030667276
- Cited by
- 254
- References
- 23
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 8 · 2016: 5 · 2015: 6 · 2014: 9 · 2013: 5 · 2012: 9
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1f32ns008804-01)
- National Institute of Mental Health (MH-41256)
- National Institute of Neurological Disorders and Stroke (NS 08804)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- glucocorticoids, corticosterone, adrenal steroids, postnatal development, dentate gyrus, developmental cell death, pyknotic cells, adrenalectomy, stress hyporesponsive period, granular layer, hilus, neurogenesis, neuronal migration, hippocampus
- MeSH terms
- Adrenal Cortex Hormones, Adrenalectomy, Animals, Animals, Newborn, Cell Survival, Corticosterone, Hippocampus, Neurons, Rats, Inbred Strains, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
