The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Localization of cannabinoid receptor mRNA in rat brain
Abstract
Cannabinoid receptor mRNA was localized in adult rat brain by 35S-tailed oligonucleotide probes and in situ hybridization histochemistry. Labelling is described as uniform or non-uniform depending on the relative intensities of individual cells expressing cannabinoid receptor mRNA within a given region or nucleus. Uniform labelling was found in the hypothalamus, thalamus, basal ganglia, cerebellum and brainstem. Non-uniform labelling that resulted from the presence of cells displaying two easily distinguishable intensities of hybridization signals was observed in several regions and nuclei in the forebrain (cerebral cortex, hippocampus, amygdala, certain olfactory structures). Olfactory-associated structures, basal ganglia, hippocampus, and cerebellar cortex displayed the heaviest amounts of labelling. Many regions that displayed cannabinoid receptor mRNA could reasonably be identified as sources for cannabinoid receptors on the basis of well documented hodologic data. Other sites that were also clearly labelled could not be assigned as logical sources of cannabinoid receptors. The localization of cannabinoid receptor mRNA indicates that sensory, motor, cognitive, limbic, and autonomic systems should all be influenced by the activation of this receptor by either exogenous cannabimimetics, including marijuana, or the yet unknown endogenous "cannabinoid" ligand.
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“CB1 receptors are localized to the central nervous system (CNS) and the periphery. CB1 receptors are found in sites associated with pain processing, including the periaqueductal gray (PAG),8 rostral ventromedial medulla (RVM),8 thalamus,9 dorsal root ganglia (DRG),10 amygdala,8 and cortex8.”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [9]
Citations
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International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
Howlett, A. C., Barth, F., Bonner, T. I., Cabral, G., Casellas, P., Devane, W. A., Felder, C. C., Herkenham, M., Mackie, K., Martin, B. R., et al. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.161 · Cited by 2,819
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
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Role of Endogenous Cannabinoids in Synaptic Signaling
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Endocannabinoid-Mediated Control of Synaptic Transmission
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Endocannabinoid Signaling in the Brain
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Metadata
- Authors
- Matsuda, L. A., Bonner, T. I., & Lolait, S. J.
- Affiliations
- National Institute of Mental Health (US)
- Corresponding author
- Matsuda, Lisa A.
- ORCID
- Lolait, Stephen J.
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 1993-01-22
- Volume
- 327
- Issue
- 4
- Pages
- 535-550
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W2025390026
- Cited by
- 631
- References
- 52
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 8 · 2022: 10 · 2021: 15 · 2020: 20 · 2019: 11 · 2018: 21 · 2017: 19 · 2016: 16 · 2015: 20 · 2014: 14 · 2013: 25 · 2012: 22
- FWCI
- 9.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- cannabinoid receptors, mRNA localization, rat brain, hypothalamus, thalamus, basal ganglia, cerebellum, brainstem, cerebral cortex, hippocampus, amygdala, endocannabinoids, cannabis
- MeSH terms
- Animals, Brain Chemistry, Male, Mesencephalon, Receptors, Drug, Rhombencephalon, RNA, Messenger, Prosencephalon, Rats, Sprague-Dawley, Receptors, Cannabinoid, Rats
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