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Cited by 46Origins and Evolution of LifeAsymmetric Synthesis and CatalysisNonlinear Dynamics and Pattern Formation

Spontaneous Emergence of Homochirality via Coherently Coupled Antagonistic and Reversible Reaction Cycles

Mauksch, Michael, Tsogoeva, Svetlana B.·2008·ChemPhysChem
DOI 10.1002/cphc.200800226
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Abstract

Asymmetric synthesis aims at obtaining enantio‐enriched products in stereoselective reactions under a chiral influence. We demonstrate both mathematically and numerically that, even under nominally achiral conditions, fully homochiral steady states can be obtained in open reactive systems by spontaneous mirror‐symmetry breaking in the homogenous solution phase when the autocatalytic reaction network is closed in the form of coherently coupled antagonistic reversible reaction cycles which, paradoxically, allow for complete recycling of the reactant. We show that the fully reversible Frank mechanism for spontaneous mirror‐symmetry breaking is closely related to the Lotka–Volterra system, which models predator–prey relations in ecosystems. Amplification of total enantiomeric excess and the principle of microscopic reversibility are not in conflict for all conceivable reactions. A viable and widely applicable reaction protocol is introduced and discussed, and it permits the theoretical implications to be applied to practical laboratory examples. Implications for the possible origin of biological homochirality on early earth are discussed.

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  • The key to overcoming the elusive search for prebiotic reactions with autocatalysis/replication and chiral amplification may lie in the establishment of self-organized connected catalytic cycles, i.e., protometabolic networks.

    “In order to overcome this elusive search for prebiotic reactions that present autocatalysis/replication with chiral amplification, as suggested by Blackmond,60 the key may lie in the establishment of self-organized connected catalytic cycles,207i.e., in the type of protometabolic networks reviewed above.”

    From The protometabolic nature of prebiotic chemistry (2023) · cites this paper as [207]

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Authors
Mauksch, M., & Tsogoeva, S. B.
Affiliations
Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
ORCID
Venue
ChemPhysChem
Publisher
Wiley
Published
2008-10-31
Volume
9
Issue
16
Pages
2359-2371
ISSN
  • 1439-4235 (ISSN-L)
  • 1439-7641
DOI
10.1002/cphc.200800226
OpenAlex
W2099542709
Cited by
46
References
10
Citations by year
2023: 1 · 2022: 1 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 3
FWCI
3.50
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • ChemPhysChem (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
  • Physical Sciences › Chemistry › Organic Chemistry › Asymmetric Synthesis and Catalysis
  • Physical Sciences › Computer Science › Computer Networks and Communications › Nonlinear Dynamics and Pattern Formation
Keywords
homochirality, spontaneous symmetry breaking, mirror symmetry breaking, autocatalytic reaction networks, enantiomeric excess, Lotka-Volterra model, origin of homochirality, early Earth, asymmetric synthesis, microscopic reversibility
MeSH terms
Algorithms, Catalysis, Kinetics, Models, Chemical, Stereoisomerism, Thermodynamics, Molecular Structure

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