The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Self‐Propelled Janus Mesoporous Silica Nanomotors with Sub‐100 nm Diameters for Drug Encapsulation and Delivery
Abstract
The synthesis of an innovative self‐propelled Janus nanomotor with a diameter of about 75 nm that can be used as a drug carrier is described. The Janus nanomotor is based on mesoporous silica nanoparticles (MSNs) with chromium/platinum metallic caps and propelled by decomposing hydrogen peroxide to generate oxygen as a driving force with speeds up to 20.2 μm s−1 (about 267 body lengths per second). The diffusion coefficient (D) of nanomotors with different H 2 O 2 concentrations is calculated by tracking the movement of individual particles recorded by means of a self‐assembled fluorescence microscope and is significantly larger than free Brownian motion. The traction of a single Janus MSN nanomotor is estimated to be about 13.47×10−15 N. Finally, intracellular localization and drug release in vitro shows that the amount of Janus MSN nanomotors entering the cells is more than MSNs with same culture time and particle concentrations, meanwhile anticancer drug doxorubicin hydrochloride loaded in Janus MSNs can be slowly released by biodegradation of lipid bilayers in cells.
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Citations
Cites
On the controllable soft-templating approach to mesoporous silicates
Wan, Y., & Zhao (2007) · Chemical Reviews · doi:10.1021/cr068020s · Cited by 2,371
Cited by
Chemically Powered Micro‐ and Nanomotors
Sánchez, S., Soler, L., & Katuri, J. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201406096 · Cited by 1,011
Acoustically Propelled Nanomotors for Intracellular siRNA Delivery
Esteban-Fernández de Ávila, B., Angell, C., Soto, F., Lopez-Ramirez, M. A., Báez, D. F., Xie, S., Wang, J., & Chen, Y. (2016) · ACS Nano · doi:10.1021/acsnano.6b01415 · Cited by 309
A self-directed Trojanbot-enzymatic nanobot in neutrobot for active target therapy of glioblastoma
Gao, Y., Mao, M., Li, Y., Xuan, M., Wu, Y., & He, Q. (2025) · Nature Communications · doi:10.1038/s41467-025-60422-z · Cited by 42
Self-citation
Metadata
- Authors
- Xuan, M., Shao, J., Lin, X., Dai, L., & He, Q.
- Venue
- ChemPhysChem
- Publisher
- Wiley
- Published
- 2014-04-16
- Volume
- 15
- Issue
- 11
- Pages
- 2255-2260
- ISSN
- 1439-4235 (ISSN-L)
- 1439-7641
- OpenAlex
- W2159208715
- Cited by
- 186
- References
- 1
- FWCI
- 13.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Xuan, M., Shao, J., Lin, X., Dai, L., & He, Q. (2014). Self‐Propelled Janus Mesoporous Silica Nanomotors with Sub‐100 nm Diameters for Drug Encapsulation and Delivery. ChemPhysChem. https://doi.org/10.1002/cphc.201402111
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