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Cited by 530

The DOI matches its Crossref record; 532 of the 532 references it cites were found in a registry or an index.

Peripheral Chemoreceptors: Function and Plasticity of the Carotid Body

Open access
Kumar, Prem, Prabhakar, Nanduri R.·2012·Comprehensive Physiology
DOI 10.1002/cphy.c100069
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Abstract

The discovery of the sensory nature of the carotid body dates back to the beginning of the 20th century. Following these seminal discoveries, research into carotid body mechanisms moved forward progressively through the 20th century, with many descriptions of the ultrastructure of the organ and stimulus‐response measurements at the level of the whole organ. The later part of 20th century witnessed the first descriptions of the cellular responses and electrophysiology of isolated and cultured type I and type II cells, and there now exist a number of testable hypotheses of chemotransduction. The goal of this article is to provide a comprehensive review of current concepts on sensory transduction and transmission of the hypoxic stimulus at the carotid body with an emphasis on integrating cellular mechanisms with the whole organ responses and highlighting the gaps or discrepancies in our knowledge. It is increasingly evident that in addition to hypoxia, the carotid body responds to a wide variety of blood‐borne stimuli, including reduced glucose and immune‐related cytokines and we therefore also consider the evidence for a polymodal function of the carotid body and its implications. It is clear that the sensory function of the carotid body exhibits considerable plasticity in response to the chronic perturbations in environmental O 2 that is associated with many physiological and pathological conditions. The mechanisms and consequences of carotid body plasticity in health and disease are discussed in the final sections of this article. © 2012 American Physiological Society.Compr Physiol 2:141‐219, 2012.

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Metadata

Authors
Kumar, P., & Prabhakar, N. R.
Venue
Comprehensive Physiology
Publisher
Wiley
Published
2012-01
Volume
2
Issue
1
Pages
141-219
ISSN
2040-4603 (ISSN-L)
DOI
10.1002/cphy.c100069
OpenAlex
W1744173909
Cited by
530
References
532
Type
other
Language
en
Open access
green

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