Insulin Regulation of Hepatic Lipid Homeostasis
Uehara, Kahealani, Santoleri, Dominic, Whitlock, Anna E. Garcia, Titchenell, Paul M.·2023·Comprehensive Physiology
Cites (362)
Items 201–362 of 362
- Cleavage of Sterol Regulatory Element-binding Proteins (SREBPs) at Site-1 Requires Interaction with SREBP Cleavage-activating ProteinJuro Sakai, Axel Nohturfft, Joseph L. Goldstein, Michael S. Brown · 1998 · Journal of Biological Chemistry
- Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein-B lipoprotein assemblyDavid A. Gordon, Haris Jamil · 2000 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Preparation and Properties of Serum and Plasma Proteins. XXV. Composition and Properties of Human Serum β-Lipoprotein1,2,3John L. Oncley, Frank R. N. Gurd, Marshall Melin · 1950 · Journal of the American Chemical Society
- Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice #Qiong A Wang, Lei Jiang, Jue Wang, Shoufeng Li, Yue Yu, Jia You, Rong Zeng, Xiang Gao, Liangyou Rui, Wenjun Li et al. · 2008 · Hepatology
- ChREBP regulates fructose-induced glucose production independently of insulin signalingKim, Mi-Sung, Krawczyk, Sarah A., Doridot, Ludivine, Fowler, Alan J., Wang, Jennifer X., Trauger, Sunia A., Noh, Hye-Lim, Kang, Hee Joon, Meissen, John K., Blatnik, Matthew et al. · 2016 · Journal of Clinical Investigation
- A new iron-sulfur flavoprotein of the respiratory chain. A component of the fatty acid beta oxidation pathwayFrank J. Ruzicka, Helmut Beinert · 1977 · Journal of Biological Chemistry
- Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory elementbinding protein-1cBronwyn D. Hegarty, Alexandre Bobard, Isabelle Hainault, Pascal Ferré, Pascale Bossard, Fabienne Foufelle · 2005 · Proceedings of the National Academy of Sciences
- Tuberous sclerosis complex tumor suppressor–mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independentAnja Jaeschke, Jörg Hartkamp, Masao Saitoh, Wendy Roworth, Takahiro Nobukuni, Angela Hodges, Julian R. Sampson, George Thomas, Richard F. Lamb · 2002 · The Journal of Cell Biology
- Hepatic Insulin Signaling Is Required for Obesity-Dependent Expression of SREBP-1c mRNA but Not for Feeding-Dependent ExpressionJoel T. Haas, Ji Miao, Dipanjan Chanda, Yanning Wang, Enpeng Zhao, Mary E. Haas, Matthew D. Hirschey, Bhavapriya Vaitheesvaran, Robert V. Farese, Irwin J. Kurland et al. · 2012 · Cell Metabolism
- ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liverPierre‐Damien Denechaud, Pascale Bossard, Jean‐Marc A. Lobaccaro, Lesley J. Millatt, Bart Staels, Jean R Girard, Catherine Postic · 2008 · Journal of Clinical Investigation
- Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic menJussi Pihlajamäki, Helena K. Gylling, Tatu A. Miettinen, Markku Laakso · 2004 · Journal of Lipid Research
- Ketogenesis prevents diet-induced fatty liver injury and hyperglycemiaDavid G. Cotter, Barış Erçal, Xiaojing Huang, Jamison M. Leid, D. André d’Avignon, Mark J. Graham, Dennis J. Dietzen, Elizabeth M. Brunt, Gary J. Patti, Peter A. Crawford · 2014 · Journal of Clinical Investigation
- The Presence of a New 3‐Oxoacyl‐CoA Thiolase in Rat Liver PeroxisomesShoko Miyazawa, Takashi Osumi, Takashi Hashimoto · 1980 · European Journal of Biochemistry
- Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression.Mengjie Lin, D Gordon, John R. Wetterau · 1995 · Journal of Lipid Research
- Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient ( ob/ob ) miceKatsumi Iizuka, Bonnie Miller, Kosaku Uyeda · 2006 · American Journal of Physiology-Endocrinology and Metabolism
- Targeted Deletion of Hepatic CTP:phosphocholine Cytidylyltransferase α in Mice Decreases Plasma High Density and Very Low Density LipoproteinsRené L. Jacobs, Cecilia M. Devlin, Ira A. Tabas, Dennis E. Vance · 2004 · Journal of Biological Chemistry
- Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factorsRebecca A. Haeusler, Kirsten Hartil, Bhavapriya Vaitheesvaran, Isabel Arrieta‐Cruz, Colette M. Knight, Joshua R. Cook, Hélène L. Kammoun, Mark Anthony Febbraio, Roger Gutiérrez Juárez, Irwin J. Kurland et al. · 2014 · Nature Communications
- Structural basis for the docking of mTORC1 on the lysosomal surfaceK. B. Rogala, X. Gu, Jibril F. Kedir, Monther Abu-Remaileh, Laura F. Bianchi, Alexia M S Bottino, Rikke Dueholm, Anna Niehaus, D. Overwijn, Ange-Célia Priso Fils et al. · 2019 · Science
- Inhibition of Microsomal Triglyceride Transfer Protein: Another Mechanism for Drug–Induced Steatosis in MicePhilippe Lettéron, Angéla Sutton, Abdellah Mansouri, Bernard Fromenty, Dominique Pessayre · 2003 · Hepatology
- The regulation of ApoB metabolism by insulinMary E. Haas, Alan Attie, Sudha B. Biddinger · 2013 · Trends in Endocrinology and Metabolism
- Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia.Robert Martin O'Doherty, Donna L. Lehman, Sabine Télémaque, Christopher B. Newgard · 1999 · Diabetes
- Transcriptional regulation of the apoC-III gene by insulin in diabetic mice: correlation with changes in plasma triglyceride levels.M Chen, Jan L. Breslow, Wentian Li, Todd Leff · 1994 · Journal of Lipid Research
- A Deficiency of Carnitine–Acylcarnitine Translocase in the Inner Mitochondrial MembraneCharles A. Stanley, Daniel Esten Hale, Gerard T. Berry, Susan Deleeuw, Jay Boxer, Jean‐Paul Bonnefont · 1992 · New England Journal of Medicine
- Postprandial metabolism of meal triglyceride in humansLambert, Jennifer E., Parks, Elizabeth J. · 2012 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Fasting hypoglycemia resulting from hepatic carnitine palmitoyl transferase deficiencyP.F. Bougneres, Jean-M. Saudubray, C. Marsac, Olivier Bernard, Michel Odièvre, Jean R Girard · 1981 · The Journal of Pediatrics
- REGULATORY ROLE OF TRIIODOTHYRONINE IN THE DEGRADATION OF LOW DENSITY LIPOPROTEIN BY CULTURED HUMAN SKIN FIBROBLASTSAlan Chait, Edwin L. Bierman, John J. Albers · 1979 · The Journal of Clinical Endocrinology & Metabolism
- Phosphorylation of Recombinant Human ATP:Citrate Lyase by cAMP-Dependent Protein Kinase Abolishes Homotropic Allosteric Regulation of the Enzyme by Citrate and Increases the Enzyme Activity. Allosteric Activation of ATP:Citrate Lyase by Phosphorylated SugarsIrina A. Potapova, M. Raafat El‐Maghrabi, Sergey V. Doronin, William B. Benjamin · 2000 · Biochemistry
- Glucose-Dependent Transcriptional Regulation by an Evolutionarily Conserved Glucose-Sensing ModuleMing V. Li, Benny Hung-Junn Chang, Minako Imamura, Naravat Poungvarin, Lawrence Chan · 2006 · Diabetes
- The assembly and secretion of ApoB 100-containing lipoproteins in Hep G2 cells. ApoB 100 is cotranslationally integrated into lipoproteins.Jan Borén, L Graham, Margit WETTESTEN, J Scott, Ann L. White, S.‐O. Olofsson · 1992 · Journal of Biological Chemistry
- Role of insulin in lipoprotein secretion by cultured rat hepatocytes.Wolfgang Patsch, Sally W. Franz, Gustav Schonfeld · 1983 · Journal of Clinical Investigation
- Diabetes Contributes to Cholesterol Metabolism Regardless of ObesityPiia P. Simonen, Helena K. Gylling, Tatu A. Miettinen · 2002 · Diabetes Care
- Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivoTitchenell, Paul M., Chu, Qingwei, Monks, Bobby R., Birnbaum, Morris J. · 2015 · Nature Communications
- Hepatic Akt Activation Induces Marked Hypoglycemia, Hepatomegaly, and Hypertriglyceridemia With Sterol Regulatory Element Binding Protein InvolvementHiraku Ono, Hitoshi Shimano, Hideki Katagiri, Naoya Yahagi, Hideyuki Sakoda, Yukiko Onishi, Motonobu Anai, Takehide Ogihara, Midori Fujishiro, Amelia Y.I. Viana et al. · 2003 · Diabetes
- Uncoupling of Acetylation from Phosphorylation Regulates FoxO1 Function Independent of Its Subcellular LocalizationLi Qiang, Alexander S. Banks, Domenico Accili · 2010 · Journal of Biological Chemistry
- Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver diseaseFelicity Payne, Koini Lim, Amandine Girousse, Rebecca J. Brown, Nora Kory, Ann L. Robbins, Yali Xue, Alison Sleigh, Elaine K. Cochran, Claire Adams et al. · 2014 · Proceedings of the National Academy of Sciences
- Carnitine in Intermediary MetabolismJon Bremer · 1962 · Journal of Biological Chemistry
- The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro.Sophie Giorgetti‐Peraldi, Robert Ballotti, Aline Kowalski‐Chauvel, Sophie Tartare‐Deckert, Emmanuel VAN OBBERGHEN · 1993 · Journal of Biological Chemistry
- A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolismFisher, ffolliott M., Kim, MiSung, Doridot, Ludivine, Cunniff, Jeremy C., Parker, Thomas S., Levine, Daniel M., Hellerstein, Marc K., Hudgins, Lisa C., Maratos-Flier, Eleftheria, Herman, Mark A. · 2017 · Molecular Metabolism
- Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene familyDouglas G. Mashek, Karin Bornfeldt, Rosalind Coleman, Johannes Berger, David Bernlohr, Paul N. Black, Concetta Dirusso, Steven Arthur Farber, Wen Guo, Naohiro Hashimoto et al. · 2004 · Journal of Lipid Research
- Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in miceDing Ai, Chiyuan Chen, Seongah Han, Anjali Ganda, Andrew James Murphy, Rebecca A. Haeusler, Edward Benjamin Thorp, Domenico Accili, Jay D. Horton, Alan R. Tall · 2012 · Journal of Clinical Investigation
- Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in miceKaori Minehira, Stephen G. Young, Claudio J. Villanueva, Laxman Yetukuri, Matej Orešič, M K Hellerstein, Robert V. Farese, Jay D. Horton, Frédéric Preitner, Bernard Thorens et al. · 2008 · Journal of Lipid Research
- Leptin's Physiologic Role: Does the Emperor of Energy Balance Have No Clothes?Jeffrey S. Flier, Eleftheria Maratos–Flier · 2017 · Cell Metabolism
- Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acidsPanu K. Luukkonen, Auli Nick, Maarit Hölttä‐Vuori, Christoph Thiele, Elina Isokuortti, Susanna E. Lallukka-Brück, You Zhou, Antti Hakkarainen, Nina M I Lundbom, Markku Peltonen et al. · 2019 · JCI Insight
- The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and menBrowning, Jeffrey D., Baxter, Jeannie, Satapati, Santhosh, Burgess, Shawn C. · 2012 · Journal of Lipid Research
- ATP-Citrate Lyase Deficiency in the MouseAnne P. Beigneux, Cynthia Kosinski, Bryant J. Gavino, Jay D. Horton, William C. Skarnes, Stephen G. Young · 2004 · Journal of Biological Chemistry
- Effects of oleate and insulin on the production rates and cellular mRNA concentrations of apolipoproteins in HepG2 cells.Nassrin Dashti, D L Williams, Petar Alaupovic · 1989 · Journal of Lipid Research
- Characterization of Recombinant Long-Chain Rat Acyl-CoA Synthetase Isoforms 3 and 6: Identification of a Novel Variant of Isoform 6Cynthia G. Van Horn, Jorge Matías Caviglia, Lei O. Li, Shuli Wang, Deborah A. Granger, Rosalind Coleman · 2005 · Biochemistry
- Enzymes of fructose metabolism in human liverFritz Heinz, Walther Lamprecht, Joachim Kirsch · 1968 · Journal of Clinical Investigation
- Phosphoinositide 3-kinase regulatory subunit p85α suppresses insulin action via positive regulation of PTENCullen M. Taniguchi, Thien Thuan Tran, Tatsuya Kondo, Ji Luo, Kohjiro Ueki, Lewis C. Cantley, C. Ronald Kahn · 2006 · Proceedings of the National Academy of Sciences
- Cholesterol Metabolism in Human ObesityPaul John Nestel, Paul H. Schreibman, EDWARD H. AHRENS · 1973 · Journal of Clinical Investigation
- Properties of Mitochondrial and Peroxisomal Enoyl-CoA Hydratases from Rat Liver1Shuichi Furuta, Shoko Miyazawa, Takashi Osumi, Takashi Hashimoto, Nobuo Ui · 1980 · The Journal of Biochemistry
- Specific Roles of the p110α Isoform of Phosphatidylinsositol 3-Kinase in Hepatic Insulin Signaling and Metabolic RegulationVictoria Rotter Sopasakis, Pixu Liu, Ryo Suzuki, Tatsuya Kondo, Jonathon N. Winnay, Thien Thuan Tran, Tomoichiro Asano, Graham Smyth, Mini P. Sajan, Robert V. Farese et al. · 2010 · Cell Metabolism
- Effects of nutrients and hormones on transcriptional and post‐transcriptional regulation of acetyl‐CoA carboxylase in rat liverAkihiko Katsurada, Nobuko Iritani, Hitomi Fukuda, Yohko Matsumura, Naomi NISHIMOTO, Tamio Noguchi, Takehiko Tanaka · 1990 · European Journal of Biochemistry
- Effect of (−)‐hydroxycitrate upon the accumulation of lipid in the rat: I. LipogenesisAnn C. Sullivan, Joseph M. Triscari, James Gordon Campbell Hamilton, O. Neal Miller, Victor R. Wheatley · 1974 · Lipids
- Insulin Stimulation of the Fatty Acid Synthase Promoter Is Mediated by the Phosphatidylinositol 3-Kinase PathwayDong Wang, Hei Sook Sul · 1998 · Journal of Biological Chemistry
- Transcriptional Regulation of the ATP Citrate-lyase Gene by Sterol Regulatory Element-binding ProteinsRyuichiro Sato, Akihiro Okamoto, Jun Inoue, Wataru Miyamoto, Yuko Sakai, Noriaki Emoto, Hitoshi Shimano, Masatomo Maeda · 2000 · Journal of Biological Chemistry
- Splice variant rs72613567 prevents worst histologic outcomes in patients with nonalcoholic fatty liver diseaseCarlos Jose Pirola, Martin E. Garaycoechea, Diego Martin Flichman, Marco A. Arrese, Julio San Martino, Carla Gazzi, Gustavo Osvaldo Castaño, Silvia C. Sookoian · 2018 · Journal of Lipid Research
- AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in miceH. O'Neill, J. Lally, S. Galic, Melissa M. Thomas, Paymon D Azizi, M. Fullerton, Brennan K. Smith, T. Pulinilkunnil, Zhi-ping Chen, M. Samaan et al. · 2014 · Diabetologia
- Changing relative proportions of apolipoproteins CII and CIII of very low density lipoproteins in hypertriglyceridaemiaLars A. Carlson, D. Ballantyne · 1976 · Atherosclerosis
- Postprandial Hepatic Lipid Metabolism Requires Signaling though Akt2 Independent of the Transcription Factors FoxA2, FoxO1 and SREBP1cMin Wan, Karla F. Leavens, D. Saleh, R. Easton, D. Guertin, Timothy R. Peterson, K. Kaestner, D. Sabatini, M. Birnbaum · 2011 · Cell Metabolism
- Purification and Properties of Rat Liver FructokinaseRichard C. Adelman, F. John Ballard, Sidney Weinhouse · 1967 · Journal of Biological Chemistry
- Purification and properties of mitochondrial and peroxisomal 3-hydroxyacyl-CoA dehydrogenase from rat liverTakashi Osumi, Takashi Hashimoto · 1980 · Archives of Biochemistry and Biophysics
- Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of MiceRong, Shunxing, Cortés, Víctor A, Rashid, Shirya, Anderson, Norma N, McDonald, Jeffrey G, Liang, Guosheng, Moon, Young-Ah, Hammer, Robert E, Horton, Jay D · 2017 · eLife
- The effect of human C apolipoproteins on the in vitro hepatic metabolism of triglyceride emulsions in the rat.Steven H. Quarfordt, George K. Michalopoulos, Bruce David Schirmer · 1982 · Journal of Biological Chemistry
- Rat ATP citrate-lyase. Molecular cloning and sequence analysis of a full-length cDNA and mRNA abundance as a function of diet, organ, and age.Nabil A. Elshourbagy, Joseph C. Near, Peter Kmetz, Ganesh M. Sathe, Christopher Southan, James E. Strickler, Mitchell S. Gross, J F Young, Timothy N. C. Wells, Pieter H.E. Groot · 1990 · Journal of Biological Chemistry
- Hepatic De Novo Lipogenesis Is Present in Liver-Specific ACC1-Deficient MiceNaomoto Harada, Zenjun Oda, Yoshikazu Hara, Koji Fujinami, Mayumi Okawa, Katsuya Ohbuchi, Mari Yonemoto, Yuika Ikeda, Kenji Ohwaki, Katsumi Aragane et al. · 2007 · Molecular and Cellular Biology
- Fatty Acid Synthase Inhibitor TVB‐2640 Reduces Hepatic de Novo Lipogenesis in Males With Metabolic AbnormalitiesMajid Mufaqam Syed‐Abdul, Elizabeth Jane Parks, Ayman H. Gaballah, Kimberlee Bingham, Ghassan M. Hammoud, George W. Kemble, DOUGLAS I. BUCKLEY, William F. McCulloch, Camila Manrique‐Acevedo · 2019 · Hepatology
- Rat Long Chain Acyl-CoA Synthetase 5 Increases Fatty Acid Uptake and Partitioning to Cellular Triacylglycerol in McArdle-RH7777 CellsMashek, Douglas G., McKenzie, Michelle A., Van Horn, Cynthia G., Coleman, Rosalind A. · 2006 · Journal of Biological Chemistry
- Purification and Properties of Rat Liver Acyl-CoA Dehydrogenases and Electron Transfer Flavoprotein1Shuichi Furuta, Shoko MAYAZAWA, Takeshi HASHIMOTO · 1981 · The Journal of Biochemistry
- Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLDPanu K. Luukkonen, You Zhou, P.A. Nidhina Haridas, Om Prakash Dwivedi, Tuulia Hyötyläinen, Ashfaq Ali, Anne Juuti, Marja Leivonen, Taru Tukiainen, Linda L. Ahonen et al. · 2017 · Journal of Hepatology
- Acyl-CoA Dehydrogenases: Dynamic History of Protein Family EvolutionZuzana Swigoňová, Al-Walid A. Mohsen, Jerry Vockley · 2009 · Journal of Molecular Evolution
- The Citrate Enzymes: Their Structures, Mechanisms, and Biological FunctionsPaul A. Srere · 1972 · Current topics in cellular regulation
- Overexpression of Rat Long Chain Acyl-CoA Synthetase 1 Alters Fatty Acid Metabolism in Rat Primary HepatocytesLi, Lei O., Mashek, Douglas G., An, Jie, Doughman, Scott D., Newgard, Christopher B., Coleman, Rosalind A. · 2006 · Journal of Biological Chemistry
- Hepatocyte Deletion of Triglyceride‐Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in MiceNina L. Gluchowski, Katlyn R. Gabriel, Chandramohan Chitraju, Roderick Terry Bronson, Niklas Mejhert, Sebastian Boland, Kun Wang, Zon Weng Lai, Robert V. Farese, Tobias C. Walther · 2019 · Hepatology
- Overexpression of CD36 and Acyl-CoA Synthetases FATP2, FATP4 and ACSL1 Increases Fatty Acid Uptake in Human Hepatoma CellsJulia Krammer, Margarete Digel, Friedrich Ehehalt, Wolfgang Stremmel, Joachim Füllekrug, Robert Ehehalt · 2011 · International Journal of Medical Sciences
- The physiological and molecular regulation of lipoprotein assembly and secretionDaniel A. Blasiole, Roger A Davis, Alan Attie · 2007 · Molecular BioSystems
- Revisiting Human Cholesterol Synthesis and Absorption: The Reciprocity Paradigm and its Key RegulatorsPeter A. S. Alphonse, Peter J.H. Jones · 2015 · Lipids
- Hepatic Glucokinase Expression Is Associated with Lipogenesis and Fatty Liver in HumansAndreas Peter, Norbert Stefan, Alexander Čegan, Mareike Walenta, Silvia Wagner, Alfred Königsrainer, Ingmar Königsrainer, Fausto E Machicao, Fritz Schick, Hans‐Ulrich Häring et al. · 2011 · The Journal of Clinical Endocrinology & Metabolism
- Regulation of putative fatty acid transporters and Acyl-CoA synthetase in liver and adipose tissue in ob/ob mice.Riaz A. Memon, J Fuller, Arthur H. Moser, P J Smith, Carl Grünfeld, Feingold Kr · 1999 · Diabetes
- The mechanism by which rat liver glucokinase is inhibited by the regulatory proteinAnnick Vandercammen, Emile VAN SCHAFTINGEN · 1990 · European Journal of Biochemistry
- The purification and some properties of electron transfer flavoprotein and general fatty acyl coenzyme A dehydrogenase from pig liver mitochondria.CL Hall, Henry Kamin · 1975 · Journal of Biological Chemistry
- Suppression of Long Chain Acyl-CoA Synthetase 3 Decreases Hepatic de Novo Fatty Acid Synthesis through Decreased Transcriptional ActivitySo Young Bu, Mara T. Mashek, Douglas G. Mashek · 2009 · Journal of Biological Chemistry
- Diabetes Mellitus: Its differentiation into insulin-sensitive and insulin-insensitive typesHarold Percival Himsworth · 2013 · International Journal of Epidemiology
- The Transcription Factors HIF-1 and HNF-4 and the Coactivator p300 Are Involved in Insulin-regulated Glucokinase Gene Expression via the Phosphatidylinositol 3-Kinase/Protein Kinase B PathwayUlrike Roth, Katja Brechtel-Curth, Terry G. Unterman, Thomas Kietzmann · 2004 · Journal of Biological Chemistry
- Carnitine-acylcarnitine translocase deficiency with severe hypoglycemia and auriculo ventricular block. Translocase assay in permeabilized fibroblasts.Shri V. Pande, M. Brivet, Abdelhamid Slama, France Demaugre, Christian Aufrant, Jean‐Marie Saudubray · 1993 · Journal of Clinical Investigation
- Identification of a common mutation in patients with medium-chain acyl-CoA dehydrogenase deficiencyYoichi Matsubara, Kuniaki Narisawa, Shigeaki Miyabayashi, Keiya Tada, Paul M. Coates, C. Bachmann, Louis J. Elsas, Rodney J. Pollitt, William J. Rhead, Charles R. Roe · 1990 · Biochemical and Biophysical Research Communications
- Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese miceDing Ai, Juan M. Baez, Hongfeng Jiang, Donna Conlon, Antonio Hernández‐Ono, Maria D. Frank-Kamenetsky, Stuart Milstein, Kevin J. Fitzgerald, Andrew James Murphy, Connie W. Woo et al. · 2012 · Journal of Clinical Investigation
- Gene knockout of Acc2 has little effect on body weight, fat mass, or food intakeOlson, David P., Pulinilkunnil, Thomas, Cline, Gary W., Shulman, Gerald I., Lowell, Bradford B. · 2010 · Proceedings of the National Academy of Sciences
- Effects of Mannose and Fructose on the Synthesis and Secretion of InsulinDONALD L. CURRY · 1989 · Pancreas
- The Critical Role of AKT2 in Hepatic Steatosis Induced by PTEN LossLina He, Xiaogang Hou, Gary C. Kanel, Ni Zeng, Vivian A. Galicia, Ying Wang, Jian Yang, Hong Wu, Morris J. Birnbaum, Bangyan L. Stiles · 2010 · American Journal Of Pathology
- Insulin-Driven PI3K-AKT Signaling in the Hepatocyte Is Mediated by Redundant PI3Kα and PI3Kβ Activities and Is Promoted by RASAngela Molinaro, Barbara Becattini, Arianna Mazzoli, Augusto Bleve, Lucia Radici, Ingela Maxvall, Victoria Rotter Sopasakis, Antonio Molinaro, Fredrik Bäckhed, Giovanni Solinas · 2019 · Cell Metabolism
- Glucokinase Activators for Diabetes TherapyFranz M. Matschinsky, Bogumił Zelent, Nicolai M. Doliba, Changhong Li, Jane M. Vanderkooi, Ali Naji, Ramakanth Sarabu, Joseph S. Grimsby · 2011 · Diabetes Care
- Inactivating hepatic follistatin alleviates hyperglycemiaTao, Rongya, Wang, Caixia, Stöhr, Oliver, Qiu, Wei, Hu, Yue, Miao, Ji, Dong, X. Charlie, Leng, Sining, Stefater, Margaret, Stylopoulos, Nicholas et al. · 2018 · Nature Medicine
- Insulin Enhances the Biogenesis of Nuclear Sterol Regulatory Element-binding Protein (SREBP)-1c by Posttranscriptional Down-regulation of Insig-2A and Its Dissociation from SREBP Cleavage-activating Protein (SCAP)·SREBP-1c ComplexChandrahasa Reddy Yellaturu, Xiong Deng, Edwards A. Park, Rajendra Raghow, Marshall B. Elam · 2009 · Journal of Biological Chemistry
- Nuclear Receptor Liver X Receptor Is O-GlcNAc-modified in Response to GlucoseElin Holter Anthonisen, Lise Lund Berven, Sverre Holm, Maria Nygård, Hilde Irene Nebb, Line M. Grønning-Wang · 2009 · Journal of Biological Chemistry
- Hyperinsulinemia and in vivo very-low-density lipoprotein-triglyceride kineticsGeorge A. Steiner, F. J. Haynes, Gen Yoshino, M. Vranić · 1984 · American Journal of Physiology-Endocrinology and Metabolism
- Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver diseasePanu K. Luukkonen, Taru Tukiainen, Anne Juuti, Henna E. Sammalkorpi, P.A. Nidhina Haridas, Onni J Niemelä, Johanna T. Arola, Marju Orho‐Melander, Antti Hakkarainen, Petri T. Kovanen et al. · 2020 · JCI Insight
- Present status of clinical deployment of glucokinase activatorsAkinobu Nakamura, Yasuo Terauchi · 2014 · Journal of Diabetes Investigation
- Cloning and functional characterization of ACAD-9, a novel member of human acyl-CoA dehydrogenase familyJia Zhang, Weiping Zhang, Dajin Zou, Guoyou Chen, Tao Wan, Minghui Zhang, Xuetao Cao · 2002 · Biochemical and Biophysical Research Communications
- Gene structure, expression and identification of a new CTP:phosphocholine cytidylyltransferase β isoformMohammad Azharul Karim, Pam Jackson, Suzanne Jackowski · 2003 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretionWilliam J. Quinn, Min Wan, Swapnil V. Shewale, Rebecca Gelfer, Daniel James Rader, Morris J. Birnbaum, Paul M. Titchenell · 2017 · Journal of Clinical Investigation
- Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver diseaseGuo, Liang, Guo, Ying-Ying, Li, Bai-Yu, Peng, Wan-Qiu, Chang, Xin-Xia, Gao, Xin, Tang, Qi-Qun · 2019 · Journal of Biological Chemistry
- Role of Insulin in the Regulation of Proprotein Convertase Subtilisin/Kexin Type 9Ji Miao, Praveen Varma Manthena, Mary E. Haas, Alisha V. Ling, Dong‐Ju Shin, Mark J. Graham, Rosanne M. Crooke, Jingwen Liu, Sudha B. Biddinger · 2015 · Arteriosclerosis Thrombosis and Vascular Biology
- Long-chain acyl-CoA dehydrogenase is a key enzyme in the mitochondrial β-oxidation of unsaturated fatty acidsWeiping Le, Azfar S. Abbas, Howard W. Sprecher, Jerry E. Vockley, Horst Schulz · 2000 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Hepatic insulin signaling regulates VLDL secretion and atherogenesis in miceSeongah Han, Chien-Ping Liang, Marit Westerterp, Takafumi Senokuchi, Carrie L. Welch, Qizhi Wang, Michihiro Matsumoto, Domenico Accili, Alan R. Tall · 2009 · Journal of Clinical Investigation
- Investigation of Functionally Liver Selective Glucokinase Activators for the Treatment of Type 2 DiabetesGregory R. Bebernitz, Valérie Beaulieu, Bethany A. Dale, Richard W. Deacon, Alokesh Duttaroy, Jiaping Gao, Melissa S. Grondine, Ramesh C. Gupta, Mesut Kakmak, Michael Kavana et al. · 2009 · Journal of Medicinal Chemistry
- Glucose-Induced Conformational Changes in Glucokinase Mediate Allosteric Regulation: Transient Kinetic AnalysisVladi V. Heredia, Jim Thomson, David O. Nettleton, Shaoxian Sun · 2006 · Biochemistry
- Hepatic CTP:Phosphocholine Cytidylyltransferase-α Is a Critical Predictor of Plasma High Density Lipoprotein and Very Low Density LipoproteinRené L. Jacobs, Susanne Lingrell, Yang Zhao, Gordon A. Francis, Dennis E. Vance · 2007 · Journal of Biological Chemistry
- Interrelationship between Liver X Receptor α, Sterol Regulatory Element-binding Protein-1c, Peroxisome Proliferator-activated Receptor γ, and Small Heterodimer Partner in the Transcriptional Regulation of Glucokinase Gene Expression in LiverTae Hyun Kim, Hail Kim, Joo-Man Park, Seung‐Soon Im, Jin-Sik Bae, Mi-Young Kim, Ho‐Geun Yoon, Ji-Young Cha, Kyung‐Sup Kim, Yong‐Ho Ahn · 2009 · Journal of Biological Chemistry
- Carnitine palmitoyltransferase activities (EC 2.3.1.–) of rat liver mitochondriaDavid Yates, P. B. Garland · 1970 · Biochemical Journal
- Role of the PI3-kinase/mTor pathway in the regulation of the stearoyl CoA desaturase (SCD1) gene expression by insulin in liverDaniel Mauvoisin, Gabriel Rocque, Omar Arfa, Anne Radenne, Pomme Boissier, Cathérine Mounier · 2007 · Journal of Cell Communication and Signaling
- Purification and properties of short chain acyl-CoA, medium chain acyl-CoA, and isovaleryl-CoA dehydrogenases from human liver.Gaetano Finocchiaro, Michinori Ito, Kéiichi Tanaka · 1987 · Journal of Biological Chemistry
- Synthesis and secretion of apolipoprotein B from cultured liver cellsHenry N. Ginsberg · 1995 · Current Opinion in Lipidology
- Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complexJing Tian, Joseph L. Goldstein, Michael S. Brown · 2016 · Proceedings of the National Academy of Sciences
- Regulation of acetyl-coenzyme A carboxylase. I. Purification and properties of two forms of acetyl-coenzyme A carboxylase from rat liver.K. George Thampy, Salih J. Wakil · 1988 · Journal of Biological Chemistry
- Nascent VLDL phospholipid composition is altered when phosphatidylcholine biosynthesis is inhibited: evidence for a novel mechanism that regulates VLDL secretionFast, Darren G., Vance, Dennis E. · 1995 · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
- Plasma proprotein convertase subtilisin kexin type 9 is not altered in subjects with impaired glucose metabolism and type 2 diabetes mellitus, but its relationship with non-HDL cholesterol and apolipoprotein B may be modified by type 2 diabetes mellitus: The CODAM studyMartijn C.G.J. Brouwers, Jason S. Troutt, Marleen M. J. van Greevenbroek, Isabel Ferreira, Edith J. M. Feskens, Carla Kallen, Nicolaas C. Schaper, Caspar Schalkwijk, Robert J. Konrad, Coen D.A. Stehouwer · 2011 · Atherosclerosis
- PCSK9 R46L, Lower LDL, and Cardiovascular Disease Risk in Familial HypercholesterolemiaYascara Grisel Luna Saavedra, Robert Dufour, Jean Davignon, Alexis Wilfrid Baass · 2014 · Arteriosclerosis Thrombosis and Vascular Biology
- Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humansFrédéric De Ceuninck, Catherine Kargar, Catherine Ilic, Audrey Caliez, Jean‐Olivier Rolin, Thierry Umbdenstock, Cédric Vinson, Murielle Combettes, Brant A. De Fanti, Elizabeth A. Harley et al. · 2012 · British Journal of Pharmacology
- Targeting hepatic glucokinase to treat diabetes with TTP399, a hepatoselective glucokinase activatorAdrian V Vella, Jennifer L. R. Freeman, Imogene McCanless Dunn, Kit Keller, John B. Buse, Carmen Valcarce · 2019 · Science Translational Medicine
- Insulin Resistance and Bronze DiabetesHoward F. Root · 1929 · New England Journal of Medicine
- MARC1 variant rs2642438 increases hepatic phosphatidylcholines and decreases severity of non-alcoholic fatty liver disease in humansPanu K. Luukkonen, Anne Juuti, Henna E. Sammalkorpi, Anne K. Penttilä, Matej Orešič, Tuulia Hyötyläinen, Johanna T. Arola, Marju Orho‐Melander, Hannele Yki‐Järvinen · 2020 · Journal of Hepatology
- Effectors of the regulatory protein acting on liver glucokinase: a kinetic investigationMichel Detheux, Annick Vandercammen, Emile VAN SCHAFTINGEN · 1991 · European Journal of Biochemistry
- Identification of Fructose 6-Phosphate- and Fructose 1-Phosphate-binding Residues in the Regulatory Protein of GlucokinaseMaria Veiga‐da‐Cunha, Emile VAN SCHAFTINGEN · 2002 · Journal of Biological Chemistry
- Regulation of acetyl-coenzyme A carboxylase. II. Effect of fasting and refeeding on the activity, phosphate content, and aggregation state of the enzyme.K. George Thampy, Salih J. Wakil · 1988 · Journal of Biological Chemistry
- The regulatory protein of glucokinase binds to the hepatocyte matrix, but, unlike glucokinase, does not translocate during substrate stimulationLoranne Agius, Matthew Peak, Emile VAN SCHAFTINGEN · 1995 · Biochemical Journal
- Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).B S Korn, Iichiro Shimomura, Yuriy K. Bashmakov, Robert E. Hammer, Jay D. Horton, Joseph L. Goldstein, M S Brown · 1998 · Journal of Clinical Investigation
- Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activityChristian Bindesbøll, Qiong Fan, Rikke C. Nørgaard, Laura MacPherson, Hai‐Bin Ruan, Jing Wu, Thomas Åskov Pedersen, Knut Rune Steffensen, Xiaoyong Yang, Jason B. Matthews et al. · 2015 · Journal of Lipid Research
- A Receptor‐Mediated Pathway for Cholesterol Homeostasis (Nobel Lecture)Michael S. Brown, Joseph L. Goldstein · 1986 · Angewandte Chemie International Edition in English
- Hepatic Tm6sf2 overexpression affects cellular ApoB-trafficking, plasma lipid levels, hepatic steatosis and atherosclerosisNicole Ehrhardt, Michael E. Doche, Shuang Chen, Hui Z. Mao, Meghan T. Walsh, Candy Bedoya, Maha M. Guindi, Weidong Xiong, Joseph Ignatius Irudayam, Jahangir Iqbal et al. · 2017 · Human Molecular Genetics
- Insulin Resistance Induces Posttranslational Hepatic Sortilin 1 Degradation in MiceJibiao Li, David J. Matye, Tiangang Li · 2015 · Journal of Biological Chemistry
- Studies on Intracellular Translocation of Apolipoprotein B in a Permeabilized HepG2 SystemJoseph Macri, Khosrow Adeli · 1997 · Journal of Biological Chemistry
- Ablation of PI3K p110-α Prevents High-Fat Diet–Induced Liver SteatosisMohar Chattopadhyay, Elzbieta S. Selinger, Lisa M. Ballou, Richard Z. Lin · 2011 · Diabetes
- Diabetes alters LDL receptor and PCSK9 expression in rat liverMelissa I. Niesen, Mohini Bedi, Dayami Lopez · 2007 · Archives of Biochemistry and Biophysics
- Effects of nutrients and hormones on gene expression of ATP citrate‐lyase in rat liverHitomi Fukuda, Akihiko Katsurada, Nobuko Iritani · 1992 · European Journal of Biochemistry
- Activation of Liver mTORC1 Protects Against NASH via Dual Regulation of VLDL-TAG Secretion and De Novo LipogenesisKahealani Uehara, Jaimarie Sostre‐Colón, Matthew J. Gavin, Dominic Santoleri, Kelly‐Ann Leonard, René L. Jacobs, Paul M. Titchenell · 2022 · Cellular and Molecular Gastroenterology and Hepatology
- Long chain fatty acyl-CoA synthetase 5 expression is induced by insulin and glucose: involvement of sterol regulatory element-binding protein-1cYounès Achouri, Bronwyn D. Hegarty, David Allanic, D. Bécard, Isabelle Hainault, Pascal Ferré, Fabienne Foufelle · 2005 · Biochimie
- Crystal Structure of Glucokinase Regulatory ProteinAlexander Pautsch, N. Stadler, Adelheid Löhle, Wolfgang Rist, A. Berg, L. Glocker, Herbert Nar, D.J. Reinert, Martin Lenter, Armin Heckel et al. · 2013 · Biochemistry
- A genome-first approach to mortality and metabolic phenotypes in MTARC1 p.Ala165Thr (rs2642438) heterozygotes and homozygotesCarolin Victoria Schneider, Kai Markus Schneider, Donna Conlon, Joseph Park, Marijana Vujković, Inuk Zandvakili, Yi-An Ko, Christian Trautwein, Rotonya M. Carr, Pavel Strnad et al. · 2021 · Med
- MTTP-297H polymorphism reduced serum cholesterol but increased risk of non-alcoholic fatty liver disease-a cross-sectional studyPi‐Jung Hsiao, Mei‐Yueh Lee, Yeng‐Tseng Wang, He‐Jiun Jiang, Pi-Chen Lin, Yi‐Hsin Yang, Kung‐Kai Kuo · 2015 · BMC Medical Genetics
- The Hepatoselective Glucokinase Activator PF-04991532 Ameliorates Hyperglycemia without Causing Hepatic Steatosis in Diabetic RatsDerek M. Erion, Amanda Lee Lapworth, Paul A. Amor, Guoyun Bai, Nicholas B. Vera, Ronald W. Clark, Qingyun Yan, Yimin Zhu, Trenton T. Ross, Julie J. Purkal et al. · 2014 · PLoS ONE
- Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statinsJi Miao, Joel T. Haas, Praveen Varma Manthena, Yanning Wang, Enpeng Zhao, Bhavapriya Vaitheesvaran, Irwin J. Kurland, Sudha B. Biddinger · 2014 · Journal of Lipid Research
- Carbohydrate-response-element-binding protein (ChREBP) and not the liver X receptor α (LXRα) mediates elevated hepatic lipogenic gene expression in a mouse model of glycogen storage disease type 1Aldo Grefhorst, Marijke Schreurs, Maaike H. Oosterveer, Vı́ctor Cortés, Rick Havinga, Andreas W. Herling, Dirk‐Jan Reijngoud, Albert Kornelis Groen, Folkert Kuipers · 2010 · Biochemical Journal
- Role of sortilin in lipid metabolismDonna Conlon · 2019 · Current Opinion in Lipidology
- PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent mannerKari T. Chambers, Zhouji Chen, Ling Lai, Teresa C. Leone, Howard C. Towle, Anastasia Kralli, Peter A. Crawford, Brian N. Finck · 2013 · Molecular Metabolism
- Bempedoic acid for the treatment of dyslipidemiaJoel C. Marrs, Sarah L. Anderson · 2020 · Drugs in Context
- The existence of ketoacyl-CoA thiolases of differing properties and intracellular localization in ox liverB. S. Middleton · 1972 · Biochemical and Biophysical Research Communications
- Sweet Dreams for LXRMitchell A. Lazar, Timothy Mark Willson · 2007 · Cell Metabolism
- Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-ConceptKate S. Ashton, Kristin L. Andrews, Marion C. Bryan, Jie Chen, Kui Chen, Michelle Chen, Samer Chmait, Michael D. Croghan, Rod L. Cupples, Christopher H. Fotsch et al. · 2014 · Journal of Medicinal Chemistry
- A Common Gene Variant in Glucokinase Regulatory Protein Interacts With Glucose Metabolism on Diabetic Dyslipidemia: the Combined CODAM and Hoorn StudiesNynke Simons, Jacqueline M. Dekker, Marleen M. J. van Greevenbroek, Giel Nijpels, Leen M. ‘t Hart, Carla Kallen, Casper G. Schalkwijk, Nicolaas C. Schaper, Coen D.A. Stehouwer, Martijn C.G.J. Brouwers · 2016 · Diabetes Care
- Insulin-stimulated phosphorylation of ATP-citrate lyase in isolated hepatocytes. Stoichiometry and relation to the phosphoenzyme intermediate.Maria Alexander-Bridges, J L Palmer, R.H. Pointer, Edward M. Kowaloff, L.L. Koumjian, Joseph Avruch · 1982 · Journal of Biological Chemistry
- Livers with Constitutive mTORC1 Activity Resist Steatosis Independent of Feedback Suppression of AktHeidi L. Kenerson, Savitha Subramanian, Rebecca L. McIntyre, Machiko Kazami, Raymond S. W. Yeung · 2015 · PLoS ONE
- The relationship of rat liver overt carnitine palmitoyltransferase to the mitochondrial malonyl-CoA binding entity and to the latent palmitoyltransferaseIraj Ghadiminejad, E. David SAGGERSON · 1990 · Biochemical Journal
- Acute suppression of apo B secretion by insulin occurs independently of MTPJanet D. Sparks, Jeffrey M. Chamberlain, Colleen O’Dell, Irani Khatun, M. Mahmood Hussain, Charles E. Sparks · 2011 · Biochemical and Biophysical Research Communications
- New Therapeutic Approaches for Familial HypercholesterolemiaEzim Ajufo, Daniel James Rader · 2018 · Annual Review of Medicine
- Insulin stimulates triacylglycerol secretion by perfused livers from fed rats but inhibits it in livers from fasted or insulin‐deficient ratsVictor A. Zammit, David J. Lankester, Anna M. Brown, Byung‐Sung Park · 1999 · European Journal of Biochemistry
- Measuring the Adsorption of Fatty Acids to Phospholipid Vesicles by Multiple Fluorescence ProbesJeffrey R. Simard, Frits Kamp, James A. Hamilton · 2008 · Biophysical Journal
- Association of MTTP gene variants with pediatric NAFLD: A candidate-gene-based analysis of single nucleotide variations in obese childrenDongling Dai, Feiqiu Wen, Shaoming Zhou, Zhe Su, Guosheng Liu, Mingbang Wang, Jianli Zhou, Fusheng He · 2017 · PLoS ONE
- Relationship between structure and substrate‐chain‐length specificity of mitochondrial very‐long‐chain acyl‐coenzyme A dehydrogenaseMasayoshi Souri, Toshifumi Aoyama, Seiji Yamaguchi, Takashi Hashimoto · 1998 · European Journal of Biochemistry
- Cross-linking of the electron-transfer flavoprotein to electron-transfer flavoprotein-ubiquinone oxidoreductase with heterobifunctional reagentsDaniël J. Steenkamp · 1988 · Biochemical Journal
- An Address on Diabetes and Insulin: Being The Nobel Lecture Delivered at Stockholm on September 15th, 1925.Frederick G. Banting · 1926 · PubMed
- Preferential cross-linking of the small subunit of the electron-transfer flavoprotein to general acyl-CoA dehydrogenaseDaniël J. Steenkamp · 1987 · Biochemical Journal