Mitochondrial and immune response dysregulation in melanoma recurrence
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Mitochondrial and
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In melanoma research, advanced algorithms applied to integrated digital pathology and MS data have uncovered predictive patterns that elude traditional analyses.
“In melanoma research, advanced algorithms applied to integrated digital pathology and MS data have uncovered predictive patterns that elude traditional analyses [21].”
From A perspective on integrating digital pathology, proteomics, clinical data and AI analytics in cancer research (2025) · cites this paper as [21]
In a melanoma case study, integration of digital pathology and deep proteomic profiling uncovered a molecular signature predictive of recurrence in early-stage disease.
“We illustrate these principles with a case study in melanoma, where the integration of digital pathology and deep proteomic profiling uncovered a molecular signature predictive of recurrence in early-stage disease.”
From A perspective on integrating digital pathology, proteomics, clinical data and AI analytics in cancer research (2025) · cites this paper as [21]
AI-assisted segmentation has facilitated selective dissection of tumor cells and stromal areas in melanoma, enabling in-depth proteomic profiling and identification of molecular signatures associated with recurrence.
“In melanoma studies, for instance, AI-assisted segmentation has facilitated selective dissection of tumor cells and stromal areas, enabling in-depth proteomic profiling and identification of molecular signatures associated with recurrence [21].”
From A perspective on integrating digital pathology, proteomics, clinical data and AI analytics in cancer research (2025) · cites this paper as [21]
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References 10 · Cited by 18
- Authors
- Szadai, L., Guedes, J. D. S., Woldmar, N., de Almeida, N. P., Jánosi, Á. J., Rajeh, A., Kovács, F., Kriston, A., Migh, E., Wan, G., Nguyen, N., Oskolás, H., Appelqvist, R., Nogueira, F. C., Domont, G. B., Yu, K., Semenov, E. R., Malm, J., Rezeli, M., Wieslander, E., Fenyö, D., Kemény, L., Horvath, P., Németh, I. B., Marko‐Varga, G., & Gil, J.
- Affiliations
- Department of Dermatology and Allergology University of Szeged Szeged Hungary
- Universidade Federal do Rio de Janeiro (BR)
- Clinical Protein Science & Imaging, Biomedical Centre Department of Biomedical Engineering Lund University Lund Sweden
- University of Szeged (HU)
- Harvard University (US)
- HUN-REN Szegedi Biológiai Kutatóközpont (HU)
- Lund University (SE)
- Chemistry Institute Federal University of Rio de Janeiro Rio de Janeiro Brazil
- New York University (US)
- Synthetic and Systems Biology Unit Biological Research Centre Eötvös Loránd Research Network Szeged Hungary
- Tokyo Medical University (JP)
- Corresponding author
- Gil, Jeovanis
- ORCID
- Venue
- Clinical and Translational Medicine
- Publisher
- Wiley
- Published
- 2023-11
- Volume
- 13
- Issue
- 11
- Pages
- e1495-e1495
- ISSN
- 2001-1326 (ISSN-L)
- PMC
- PMC10663649
- OpenAlex
- W4388921842
- Cited by
- 18
- References
- 10
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 3
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical and Translational Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- SZTE Publicatio Repozitórium (University of Szeged) (submittedVersion, other-oa)
- Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ciência sem Fronteiras
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Fru Berta Kamprads Stiftelse
- National Institute of General Medical Sciences (R35GM142879)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- melanoma, tumor recurrence, mitochondrial dysfunction, immune dysregulation, immunotherapy resistance
- MeSH terms
- Humans, Immunity, Melanoma, Mitochondria
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