Amygdala activation in response to facial expressions in pediatric obsessive-compulsive disorder
Open accessAbstract
BACKGROUND: Exaggerated amygdala activation to threatening faces has been detected in adults and children with anxiety disorders, compared to healthy comparison (HC) subjects. However, the profile of amygdala activation in response to facial expressions in obsessive-compulsive disorder (OCD) may be a distinguishing feature; a prior study found that compared with healthy adults, adults with OCD exhibited less amygdala activation to emotional and neutral faces, relative to fixation [Cannistraro et al. (2004). Biological Psychiatry 56:916-920]. METHODS: In the current event-related functional magnetic resonance imaging (fMRI) study, a pediatric OCD sample (N=12) and a HC sample (N=17) performed a gender discrimination task while viewing emotional faces (happy, fearful, disgusted) and neutral faces. RESULTS: Compared to the HC group, the OCD group showed less amygdala/hippocampus activation in all emotion and neutral conditions relative to fixation. CONCLUSIONS: Like previous reports in adult OCD, pediatric OCD may have a distinct neural profile from other anxiety disorders, with respect to amygdala activation in response to emotional stimuli that are not disorder specific.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
When OCD patients view neutral faces or are anticipating rewards, amygdala is hypoactive compared to controls.
“Specifically, when OCD patients view neutral faces (Cannistraro et al., 2004; Britton et al., 2010) or are anticipating rewards (Marsh et al., 2015), amygdala is hypoactive compared to controls (but see Simon et al., 2014).”
From A framework for understanding the emerging role of corticolimbic-ventral striatal networks in OCD-associated repetitive behaviors (2015) · cites this paper as Britton et al., 2010
In children with obsessive-compulsive disorder, amygdala activation is decreased relative to healthy controls when viewing fear faces.
“in children with OCD, amygdala activation is decreased, relative to healthy controls.160”
From Neural Substrates of Childhood Anxiety Disorders (2012) · cites this paper as [160]
The decreased amygdala activation in childhood obsessive-compulsive disorder contrasts with other childhood anxiety disorders, providing further evidence for a distinction between obsessive-compulsive disorder and the other disorders.
“This result is in contrast to other studies in the other childhood anxiety disorders, providing further evidence for a distinction between OCD and the other disorders.”
From Neural Substrates of Childhood Anxiety Disorders (2012) · cites this paper as [160]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 63 · Cited by 40
Research works printed but not linked: 1
- [39]Talairach J Tournoux P 1988 Co-Planar Stereotactic Atlas of the Human Brain Thieme Stuttgart
- Authors
- Britton, J. C., Stewart, S. E., Killgore, W. D. S., Rosso, I. M., Price, L. M., Gold, A. L., Pine, D. S., Wilhelm, S., Jenike, M. A., & Rauch, S. L.
- Affiliations
- National Institutes of Health (US)
- Massachusetts General Hospital (US)
- McLean Hospital (US)
- Corresponding author
- Britton, Jennifer C.
- ORCID
- Venue
- Depression and Anxiety
- Publisher
- Hindawi Limited
- Published
- 2010-04-28
- Volume
- 27
- Issue
- 7
- Pages
- 643-651
- ISSN
- 1091-4269 (ISSN-L)
- 1520-6394
- PMC
- PMC2951127
- OpenAlex
- W2066065724
- Cited by
- 40
- References
- 63
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 4 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 6 · 2014: 2 · 2013: 7 · 2012: 4
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 MH999999)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Keywords
- pediatric obsessive-compulsive disorder, amygdala activation, facial expressions, emotional facial expressions, hippocampus, event-related fMRI, children
- MeSH terms
- Amygdala, Child, Facial Expression, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Obsessive-Compulsive Disorder, Sex Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
